Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-03

AUTHORS

Norbert Hubner, Caroline A Wallace, Heike Zimdahl, Enrico Petretto, Herbert Schulz, Fiona Maciver, Michael Mueller, Oliver Hummel, Jan Monti, Vaclav Zidek, Alena Musilova, Vladimir Kren, Helen Causton, Laurence Game, Gabriele Born, Sabine Schmidt, Anita Müller, Stuart A Cook, Theodore W Kurtz, John Whittaker, Michal Pravenec, Timothy J Aitman

ABSTRACT

Integration of genome-wide expression profiling with linkage analysis is a new approach to identifying genes underlying complex traits. We applied this approach to the regulation of gene expression in the BXH/HXB panel of rat recombinant inbred strains, one of the largest available rodent recombinant inbred panels and a leading resource for genetic analysis of the highly prevalent metabolic syndrome. In two tissues important to the pathogenesis of the metabolic syndrome, we mapped cis- and trans-regulatory control elements for expression of thousands of genes across the genome. Many of the most highly linked expression quantitative trait loci are regulated in cis, are inherited essentially as monogenic traits and are good candidate genes for previously mapped physiological quantitative trait loci in the rat. By comparative mapping we generated a data set of 73 candidate genes for hypertension that merit testing in human populations. Mining of this publicly available data set is expected to lead to new insights into the genes and regulatory pathways underlying the extensive range of metabolic and cardiovascular disease phenotypes that segregate in these recombinant inbred strains. More... »

PAGES

243-253

References to SciGraph publications

  • 1999-03. Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats in MAMMALIAN GENOME
  • 2002-01. Rat genetics: attachign physiology and pharmacology to the genome in NATURE REVIEWS GENETICS
  • 1992-10. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction in NATURE
  • 2001-02. Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats in NATURE GENETICS
  • 2003-03. Genetics of gene expression surveyed in maize, mouse and man in NATURE
  • 1996-02. A genetic linkage map of the rat derived from recombinant inbred strains in MAMMALIAN GENOME
  • 1996-03. Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains in BEHAVIOR GENETICS
  • 2003-08. A new framework marker-based linkage map and SDPs for the Rat HXB/BXH strain set in MAMMALIAN GENOME
  • 2004-04. Genome sequence of the Brown Norway rat yields insights into mammalian evolution in NATURE
  • 1997-06. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats in NATURE GENETICS
  • 2004-08. Genetic analysis of genome-wide variation in human gene expression in NATURE
  • 2003-09. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors in NATURE GENETICS
  • 2002-02. Molecular basis of the Cd36 chromosomal deletion underlying SHR defects in insulin action and fatty acid metabolism in MAMMALIAN GENOME
  • 1972. Spontaneous Hypertension in NONE
  • 1999-01. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats in NATURE GENETICS
  • 2004-05. The rat comes clean in NATURE GENETICS
  • 2003-03. Natural variation in human gene expression assessed in lymphoblastoid cells in NATURE GENETICS
  • 2003-11. The nature and identification of quantitative trait loci: a community's view in NATURE REVIEWS GENETICS
  • 2000-09. Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma in NATURE IMMUNOLOGY
  • 2003-09. Question 10For a given protein, how can one determine whether it contains any functional domains of interest? What other proteins contain the same functional domains as this protein? How can one determine whether there is a similarity to other proteins, not only at the sequence level, but also at the structural level? in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng1522

    DOI

    http://dx.doi.org/10.1038/ng1522

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019743219

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/15711544


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    433 MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London W12 0NN, UK.
    434 rdf:type schema:Organization
     




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