Recombination rate and reproductive success in humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-11

AUTHORS

Augustine Kong, John Barnard, Daniel F Gudbjartsson, Gudmar Thorleifsson, Gudrun Jonsdottir, Sigrun Sigurdardottir, Bjorgvin Richardsson, Jonina Jonsdottir, Thorgeir Thorgeirsson, Michael L Frigge, Neil E Lamb, Stephanie Sherman, Jeffrey R Gulcher, Kari Stefansson

ABSTRACT

Intergenerational mixing of DNA through meiotic recombinations of homologous chromosomes during gametogenesis is a major event that generates diversity in the eukaryotic genome. We examined genome-wide microsatellite data for 23,066 individuals, providing information on recombination events of 14,140 maternal and paternal meioses each, and found a positive correlation between maternal recombination counts of an offspring and maternal age. We postulated that the recombination rate of eggs does not increase with maternal age, but that the apparent increase is the consequence of selection. Specifically, a high recombination count increased the chance of a gamete becoming a live birth, and this effect became more pronounced with advancing maternal age. Further support for this hypothesis came from our observation that mothers with high oocyte recombination rate tend to have more children. Hence, not only do recombinations have a role in evolution by yielding diverse combinations of gene variants for natural selection, but they are also under selection themselves. More... »

PAGES

1203-1206

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1445

DOI

http://dx.doi.org/10.1038/ng1445

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003108550

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15467721


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