Identification of TFB5, a new component of general transcription and DNA repair factor IIH View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-06-27

AUTHORS

Jeffrey A Ranish, Steven Hahn, Yu Lu, Eugene C Yi, Xiao-jun Li, Jimmy Eng, Ruedi Aebersold

ABSTRACT

We previously described the use of quantitative proteomics to study macromolecular complexes1. Applying the method to analyze a yeast RNA polymerase II preinitiation complex, we identified a new 8-kDa protein, encoded by the uncharacterized open reading frame YDR079c-a, as a potential new component of the preinitiation complex. Here we show that YDR079c-a is a bona fide component of polymerase II preinitiation complexes and investigate its role in transcription. YDR079c-a is recruited to promoters both in vivo and in vitro and is required for efficient transcription in vitro and for normal induction of GAL genes. In addition, YDR079c-a is a core component of general transcription and DNA repair factor IIH and is required for efficient recruitment of TFIIH to a promoter. Yeast lacking YDR079c-a grow slowly, and, like strains carrying mutations in core TFIIH subunits, are sensitive to ultraviolet radiation. YDR079c-a is conserved throughout evolution, and mutations in the human ortholog account for a DNA repair–deficient form of the tricothiodystrophy disorder called TTD-A2. The identification of a new, evolutionarily conserved, core TFIIH subunit is essential for our understanding of TFIIH function in transcription, DNA repair and human disease. More... »

PAGES

707-713

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1385

DOI

http://dx.doi.org/10.1038/ng1385

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044860890

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15220919


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