Gene expression–based high-throughput screening(GE-HTS) and application to leukemia differentiation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-03

AUTHORS

Kimberly Stegmaier, Kenneth N Ross, Sierra A Colavito, Shawn O'Malley, Brent R Stockwell, Todd R Golub

ABSTRACT

Chemical genomics involves generating large collections of small molecules and using them to modulate cellular states. Despite recent progress in the systematic synthesis of structurally diverse compounds, their use in screens of cellular circuitry is still an ad hoc process. Here, we outline a general, efficient approach called gene expression-based high-throughput screening (GE-HTS) in which a gene expression signature is used as a surrogate for cellular states, and we describe its application in a particular setting: the identification of compounds that induce the differentiation of acute myeloid leukemia cells. In screening 1,739 compounds, we identified 8 that reliably induced the differentiation signature and, furthermore, yielded functional evidence of bona fide differentiation. The results indicate that GE-HTS may be a powerful, general approach for chemical screening. More... »

PAGES

257

References to SciGraph publications

  • 1999-01-15. Assay for Phagocytosis in IMMUNOCYTOCHEMICAL METHODS AND PROTOCOLS
  • 2002-04. Profiling alternative splicing on fiber-optic arrays in NATURE BIOTECHNOLOGY
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    http://scigraph.springernature.com/pub.10.1038/ng1305

    DOI

    http://dx.doi.org/10.1038/ng1305

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/14770183


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