An integrated metric physical map of human chromosome 19 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-12

AUTHORS

Linda K. Ashworth, Mark A. Batzer, Brigitte Brandriff, Elbert Branscomb, Pieter de Jong, Emilio Garcia, Jeffrey A. Garnes, Laurie A. Gordon, Jane E. Lamerdin, Greg Lennon, Harvey Mohrenweiser, Anne S. Olsen, Tom Slezak, Anthony V. Carrano

ABSTRACT

A metric physical map of human chromosome 19 has been generated. The foundation of the map is sets of overlapping cosmids (contigs) generated by automated fingerprinting spanning over 95% of the euchromatin, about 50 megabases (Mb). Distances between selected cosmid clones were estimated using fluorescence in situ hybridization in sperm pronuclei, providing both order and distance between contigs. An average inter–marker separation of 230 kb has been obtained across the non–centromeric portion of the chromosome. Various types of larger insert clones were used to span gaps between contigs. Currently, the map consists of 51 ‘islands’ containing multiple clone types, whose size, order and relative distance are known. Over 450 genes, genetic markers, sequence tagged sites (STSs), anonymous cDNAs, and other markers have been localized. In addition, EcoRI restriction maps have been generated for >41 Mb (∼83%) of the chromosome. More... »

PAGES

422-427

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1295-422

DOI

http://dx.doi.org/10.1038/ng1295-422

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002089351

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7493023


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 19", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cosmids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Fingerprinting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxyribonuclease EcoRI", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Markers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Restriction Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spermatozoa", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ashworth", 
        "givenName": "Linda K.", 
        "id": "sg:person.01223477370.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223477370.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Batzer", 
        "givenName": "Mark A.", 
        "id": "sg:person.01106275701.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106275701.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brandriff", 
        "givenName": "Brigitte", 
        "id": "sg:person.074207343.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074207343.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Branscomb", 
        "givenName": "Elbert", 
        "id": "sg:person.0752761402.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752761402.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roswell Park Cancer Institute, Buffalo, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.240614.5", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
            "Roswell Park Cancer Institute, Buffalo, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Jong", 
        "givenName": "Pieter", 
        "id": "sg:person.014644352072.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014644352072.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garcia", 
        "givenName": "Emilio", 
        "id": "sg:person.01311153643.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311153643.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Garnes", 
        "givenName": "Jeffrey A.", 
        "id": "sg:person.01167721010.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167721010.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gordon", 
        "givenName": "Laurie A.", 
        "id": "sg:person.01215510270.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215510270.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lamerdin", 
        "givenName": "Jane E.", 
        "id": "sg:person.0773065610.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773065610.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lennon", 
        "givenName": "Greg", 
        "id": "sg:person.015424672714.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015424672714.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohrenweiser", 
        "givenName": "Harvey", 
        "id": "sg:person.0734374053.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734374053.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olsen", 
        "givenName": "Anne S.", 
        "id": "sg:person.0746125712.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746125712.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Slezak", 
        "givenName": "Tom", 
        "id": "sg:person.01202663067.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202663067.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250008.f", 
          "name": [
            "Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carrano", 
        "givenName": "Anthony V.", 
        "id": "sg:person.01213615340.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213615340.40"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/366698a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038278113", 
          "https://doi.org/10.1038/366698a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0795-325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017613687", 
          "https://doi.org/10.1038/ng0795-325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0795-330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031606689", 
          "https://doi.org/10.1038/ng0795-330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/369421a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004048588", 
          "https://doi.org/10.1038/369421a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/359380a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050152276", 
          "https://doi.org/10.1038/359380a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0694supp-246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042223854", 
          "https://doi.org/10.1038/ng0694supp-246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00173169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021001883", 
          "https://doi.org/10.1007/bf00173169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0194-84", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027542612", 
          "https://doi.org/10.1038/ng0194-84"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/355548a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039513377", 
          "https://doi.org/10.1038/355548a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0492-34", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000554284", 
          "https://doi.org/10.1038/ng0492-34"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0993-40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027738533", 
          "https://doi.org/10.1038/ng0993-40"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-12", 
    "datePublishedReg": "1995-12-01", 
    "description": "A metric physical map of human chromosome 19 has been generated. The foundation of the map is sets of overlapping cosmids (contigs) generated by automated fingerprinting spanning over 95% of the euchromatin, about 50 megabases (Mb). Distances between selected cosmid clones were estimated using fluorescence in situ hybridization in sperm pronuclei, providing both order and distance between contigs. An average inter\u2013marker separation of 230 kb has been obtained across the non\u2013centromeric portion of the chromosome. Various types of larger insert clones were used to span gaps between contigs. Currently, the map consists of 51 \u2018islands\u2019 containing multiple clone types, whose size, order and relative distance are known. Over 450 genes, genetic markers, sequence tagged sites (STSs), anonymous cDNAs, and other markers have been localized. In addition, EcoRI restriction maps have been generated for >41 Mb (\u223c83%) of the chromosome.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ng1295-422", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "human chromosome 19", 
      "physical map", 
      "chromosome 19", 
      "large insert clones", 
      "EcoRI restriction map", 
      "anonymous cDNAs", 
      "cosmid clones", 
      "tagged sites", 
      "genetic markers", 
      "restriction map", 
      "sperm pronucleus", 
      "situ hybridization", 
      "contigs", 
      "clone types", 
      "chromosomes", 
      "clones", 
      "cosmids", 
      "megabases", 
      "cDNA", 
      "genes", 
      "kb", 
      "pronuclei", 
      "hybridization", 
      "markers", 
      "sites", 
      "fingerprinting", 
      "islands", 
      "MB", 
      "fluorescence", 
      "maps", 
      "types", 
      "portion", 
      "distance", 
      "addition", 
      "size", 
      "set", 
      "order", 
      "relative distance", 
      "foundation", 
      "separation", 
      "gap", 
      "metric physical map", 
      "average inter\u2013marker separation", 
      "inter\u2013marker separation", 
      "non\u2013centromeric portion", 
      "insert clones", 
      "multiple clone types", 
      "integrated metric physical map"
    ], 
    "name": "An integrated metric physical map of human chromosome 19", 
    "pagination": "422-427", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002089351"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng1295-422"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7493023"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng1295-422", 
      "https://app.dimensions.ai/details/publication/pub.1002089351"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_301.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ng1295-422"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng1295-422'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng1295-422'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng1295-422'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng1295-422'


 

This table displays all metadata directly associated to this object as RDF triples.

301 TRIPLES      22 PREDICATES      99 URIs      80 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng1295-422 schema:about N4700488703a940c2ac91d0976f0e432a
2 N5b97f910c765457bb4ab5b16c83c9126
3 N5ca28ade391c411a9060f4aa17a1b066
4 N6649c2e521e142ce9e85b047dafebf6c
5 N7fb1729669cf4b46b9937bf638e7d243
6 Na495d047f97d4d589791b393585eb8dc
7 Nb4a607564b6d41f48507026889733022
8 Nb7d1d0cc7fed4a53a2b7995707ecd04a
9 Nc94a1c1c8b4e48d79aeeaac36a0132b8
10 Ncf1ea596f827402e968a6cfd497e01cc
11 Nd476e13cfe2e4a83959da2b20f002f1b
12 Ne20dfbeab435411c808cf1ea88994f51
13 Neeb957991d41465782d305d7bcd20dee
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author N44d874fc77e24838a0166fb9bb36f0b4
17 schema:citation sg:pub.10.1007/bf00173169
18 sg:pub.10.1038/355548a0
19 sg:pub.10.1038/359380a0
20 sg:pub.10.1038/366698a0
21 sg:pub.10.1038/369421a0
22 sg:pub.10.1038/ng0194-84
23 sg:pub.10.1038/ng0492-34
24 sg:pub.10.1038/ng0694supp-246
25 sg:pub.10.1038/ng0795-325
26 sg:pub.10.1038/ng0795-330
27 sg:pub.10.1038/ng0993-40
28 schema:datePublished 1995-12
29 schema:datePublishedReg 1995-12-01
30 schema:description A metric physical map of human chromosome 19 has been generated. The foundation of the map is sets of overlapping cosmids (contigs) generated by automated fingerprinting spanning over 95% of the euchromatin, about 50 megabases (Mb). Distances between selected cosmid clones were estimated using fluorescence in situ hybridization in sperm pronuclei, providing both order and distance between contigs. An average inter–marker separation of 230 kb has been obtained across the non–centromeric portion of the chromosome. Various types of larger insert clones were used to span gaps between contigs. Currently, the map consists of 51 ‘islands’ containing multiple clone types, whose size, order and relative distance are known. Over 450 genes, genetic markers, sequence tagged sites (STSs), anonymous cDNAs, and other markers have been localized. In addition, EcoRI restriction maps have been generated for >41 Mb (∼83%) of the chromosome.
31 schema:genre article
32 schema:inLanguage en
33 schema:isAccessibleForFree false
34 schema:isPartOf N1af5eb77cf9e4a2c92ae22449dd3b16a
35 Naf243083f57d4040bbea94f168ee416f
36 sg:journal.1103138
37 schema:keywords EcoRI restriction map
38 MB
39 addition
40 anonymous cDNAs
41 average inter–marker separation
42 cDNA
43 chromosome 19
44 chromosomes
45 clone types
46 clones
47 contigs
48 cosmid clones
49 cosmids
50 distance
51 fingerprinting
52 fluorescence
53 foundation
54 gap
55 genes
56 genetic markers
57 human chromosome 19
58 hybridization
59 insert clones
60 integrated metric physical map
61 inter–marker separation
62 islands
63 kb
64 large insert clones
65 maps
66 markers
67 megabases
68 metric physical map
69 multiple clone types
70 non–centromeric portion
71 order
72 physical map
73 portion
74 pronuclei
75 relative distance
76 restriction map
77 separation
78 set
79 sites
80 situ hybridization
81 size
82 sperm pronucleus
83 tagged sites
84 types
85 schema:name An integrated metric physical map of human chromosome 19
86 schema:pagination 422-427
87 schema:productId Nb6e72be1ed7c463fa51881aec2f44cad
88 Nb7e73366d7654cd1a7bce3e3363049b8
89 Nd2aab02b9d4f4a7990817604d8e70085
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002089351
91 https://doi.org/10.1038/ng1295-422
92 schema:sdDatePublished 2021-12-01T19:10
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N91a797465f604cf3b6c1e75f9be9512b
95 schema:url https://doi.org/10.1038/ng1295-422
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N14463f066c06470fadf0fbeae66b25f0 rdf:first sg:person.015424672714.81
100 rdf:rest N729f7307f6654837b2414890b547bc68
101 N192c8a11494a4e5aa26bbaf54d940232 rdf:first sg:person.074207343.44
102 rdf:rest N8d84196ee584463f8723c3163ccd7b15
103 N1af5eb77cf9e4a2c92ae22449dd3b16a schema:issueNumber 4
104 rdf:type schema:PublicationIssue
105 N34da43c8651c453fa964fe4f0934f3e3 rdf:first sg:person.0773065610.39
106 rdf:rest N14463f066c06470fadf0fbeae66b25f0
107 N44d874fc77e24838a0166fb9bb36f0b4 rdf:first sg:person.01223477370.02
108 rdf:rest Nae8e06d31dd641f4ae7d8573a88c5734
109 N4700488703a940c2ac91d0976f0e432a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Molecular Sequence Data
111 rdf:type schema:DefinedTerm
112 N5b97f910c765457bb4ab5b16c83c9126 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name In Situ Hybridization, Fluorescence
114 rdf:type schema:DefinedTerm
115 N5ca28ade391c411a9060f4aa17a1b066 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Deoxyribonuclease EcoRI
117 rdf:type schema:DefinedTerm
118 N6649c2e521e142ce9e85b047dafebf6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name DNA Fingerprinting
120 rdf:type schema:DefinedTerm
121 N729f7307f6654837b2414890b547bc68 rdf:first sg:person.0734374053.67
122 rdf:rest Ncd12d0fa1eb046e48e9942abd54ef54b
123 N7fb1729669cf4b46b9937bf638e7d243 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Base Sequence
125 rdf:type schema:DefinedTerm
126 N8c4ccaeb98ad483086915220a286b73d rdf:first sg:person.014644352072.19
127 rdf:rest N8f4b0a11b9da41d4870495d6647ade84
128 N8d84196ee584463f8723c3163ccd7b15 rdf:first sg:person.0752761402.53
129 rdf:rest N8c4ccaeb98ad483086915220a286b73d
130 N8f4b0a11b9da41d4870495d6647ade84 rdf:first sg:person.01311153643.04
131 rdf:rest N913bf7da172d4cd6b210971f42846f6b
132 N913bf7da172d4cd6b210971f42846f6b rdf:first sg:person.01167721010.47
133 rdf:rest Ncfcae9dc0f9e4663abf8fdb8be3fdd09
134 N91a797465f604cf3b6c1e75f9be9512b schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 Na495d047f97d4d589791b393585eb8dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Chromosome Mapping
138 rdf:type schema:DefinedTerm
139 Nae8e06d31dd641f4ae7d8573a88c5734 rdf:first sg:person.01106275701.28
140 rdf:rest N192c8a11494a4e5aa26bbaf54d940232
141 Naf243083f57d4040bbea94f168ee416f schema:volumeNumber 11
142 rdf:type schema:PublicationVolume
143 Nb4a607564b6d41f48507026889733022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Restriction Mapping
145 rdf:type schema:DefinedTerm
146 Nb6e72be1ed7c463fa51881aec2f44cad schema:name dimensions_id
147 schema:value pub.1002089351
148 rdf:type schema:PropertyValue
149 Nb7d1d0cc7fed4a53a2b7995707ecd04a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Genetic Markers
151 rdf:type schema:DefinedTerm
152 Nb7e73366d7654cd1a7bce3e3363049b8 schema:name pubmed_id
153 schema:value 7493023
154 rdf:type schema:PropertyValue
155 Nbe5dcb70b8f84cc89de4f4af190e417a rdf:first sg:person.01202663067.66
156 rdf:rest Ne86b18b520024eef922553249bd292b6
157 Nc94a1c1c8b4e48d79aeeaac36a0132b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Cosmids
159 rdf:type schema:DefinedTerm
160 Ncd12d0fa1eb046e48e9942abd54ef54b rdf:first sg:person.0746125712.58
161 rdf:rest Nbe5dcb70b8f84cc89de4f4af190e417a
162 Ncf1ea596f827402e968a6cfd497e01cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Male
164 rdf:type schema:DefinedTerm
165 Ncfcae9dc0f9e4663abf8fdb8be3fdd09 rdf:first sg:person.01215510270.54
166 rdf:rest N34da43c8651c453fa964fe4f0934f3e3
167 Nd2aab02b9d4f4a7990817604d8e70085 schema:name doi
168 schema:value 10.1038/ng1295-422
169 rdf:type schema:PropertyValue
170 Nd476e13cfe2e4a83959da2b20f002f1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Chromosomes, Human, Pair 19
172 rdf:type schema:DefinedTerm
173 Ne20dfbeab435411c808cf1ea88994f51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Spermatozoa
175 rdf:type schema:DefinedTerm
176 Ne86b18b520024eef922553249bd292b6 rdf:first sg:person.01213615340.40
177 rdf:rest rdf:nil
178 Neeb957991d41465782d305d7bcd20dee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Humans
180 rdf:type schema:DefinedTerm
181 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biological Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
185 schema:name Genetics
186 rdf:type schema:DefinedTerm
187 sg:journal.1103138 schema:issn 1061-4036
188 1546-1718
189 schema:name Nature Genetics
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.01106275701.28 schema:affiliation grid-institutes:grid.250008.f
193 schema:familyName Batzer
194 schema:givenName Mark A.
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106275701.28
196 rdf:type schema:Person
197 sg:person.01167721010.47 schema:affiliation grid-institutes:grid.250008.f
198 schema:familyName Garnes
199 schema:givenName Jeffrey A.
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167721010.47
201 rdf:type schema:Person
202 sg:person.01202663067.66 schema:affiliation grid-institutes:grid.250008.f
203 schema:familyName Slezak
204 schema:givenName Tom
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202663067.66
206 rdf:type schema:Person
207 sg:person.01213615340.40 schema:affiliation grid-institutes:grid.250008.f
208 schema:familyName Carrano
209 schema:givenName Anthony V.
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213615340.40
211 rdf:type schema:Person
212 sg:person.01215510270.54 schema:affiliation grid-institutes:grid.250008.f
213 schema:familyName Gordon
214 schema:givenName Laurie A.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215510270.54
216 rdf:type schema:Person
217 sg:person.01223477370.02 schema:affiliation grid-institutes:grid.250008.f
218 schema:familyName Ashworth
219 schema:givenName Linda K.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223477370.02
221 rdf:type schema:Person
222 sg:person.01311153643.04 schema:affiliation grid-institutes:grid.250008.f
223 schema:familyName Garcia
224 schema:givenName Emilio
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311153643.04
226 rdf:type schema:Person
227 sg:person.014644352072.19 schema:affiliation grid-institutes:grid.240614.5
228 schema:familyName de Jong
229 schema:givenName Pieter
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014644352072.19
231 rdf:type schema:Person
232 sg:person.015424672714.81 schema:affiliation grid-institutes:grid.250008.f
233 schema:familyName Lennon
234 schema:givenName Greg
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015424672714.81
236 rdf:type schema:Person
237 sg:person.0734374053.67 schema:affiliation grid-institutes:grid.250008.f
238 schema:familyName Mohrenweiser
239 schema:givenName Harvey
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734374053.67
241 rdf:type schema:Person
242 sg:person.074207343.44 schema:affiliation grid-institutes:grid.250008.f
243 schema:familyName Brandriff
244 schema:givenName Brigitte
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.074207343.44
246 rdf:type schema:Person
247 sg:person.0746125712.58 schema:affiliation grid-institutes:grid.250008.f
248 schema:familyName Olsen
249 schema:givenName Anne S.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746125712.58
251 rdf:type schema:Person
252 sg:person.0752761402.53 schema:affiliation grid-institutes:grid.250008.f
253 schema:familyName Branscomb
254 schema:givenName Elbert
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752761402.53
256 rdf:type schema:Person
257 sg:person.0773065610.39 schema:affiliation grid-institutes:grid.250008.f
258 schema:familyName Lamerdin
259 schema:givenName Jane E.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773065610.39
261 rdf:type schema:Person
262 sg:pub.10.1007/bf00173169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021001883
263 https://doi.org/10.1007/bf00173169
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/355548a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039513377
266 https://doi.org/10.1038/355548a0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/359380a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050152276
269 https://doi.org/10.1038/359380a0
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/366698a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038278113
272 https://doi.org/10.1038/366698a0
273 rdf:type schema:CreativeWork
274 sg:pub.10.1038/369421a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004048588
275 https://doi.org/10.1038/369421a0
276 rdf:type schema:CreativeWork
277 sg:pub.10.1038/ng0194-84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027542612
278 https://doi.org/10.1038/ng0194-84
279 rdf:type schema:CreativeWork
280 sg:pub.10.1038/ng0492-34 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000554284
281 https://doi.org/10.1038/ng0492-34
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/ng0694supp-246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042223854
284 https://doi.org/10.1038/ng0694supp-246
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/ng0795-325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017613687
287 https://doi.org/10.1038/ng0795-325
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/ng0795-330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031606689
290 https://doi.org/10.1038/ng0795-330
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/ng0993-40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027738533
293 https://doi.org/10.1038/ng0993-40
294 rdf:type schema:CreativeWork
295 grid-institutes:grid.240614.5 schema:alternateName Roswell Park Cancer Institute, Buffalo, New York, USA
296 schema:name Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA
297 Roswell Park Cancer Institute, Buffalo, New York, USA
298 rdf:type schema:Organization
299 grid-institutes:grid.250008.f schema:alternateName Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA
300 schema:name Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, PO Box 808, 94551, Livermore, California, USA
301 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...