Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12

AUTHORS

J. Simard, P. Tonin, F. Durocher, K. Morgan, J. Rommens, S. Gingras, C. Samson, J.-F. Leblanc, C. Bélanger, F. Dion, Q. Liu, M. Skolnick, D. Goldgar, D. Shattuck-Eidens, F. Labrie, S.A. Narod

ABSTRACT

Women who carry mutations in the BRCA1 gene on chromosome 17q have an 85% lifetime risk of breast cancer, and a 60% risk of ovarian cancer. We have identified BRCA1 mutations in 12 of 30 (40%) Canadian families with breast and/or ovarian cancer, including six of the eight families (75%) that contained two cases of early-onset breast cancer and two cases of ovarian cancer. Six frameshift mutations account for all 12 mutant alleles, including nucleotide insertions (two mutations) and deletions (four mutations). Four independent families carried the same 1 basepair (bp) insertion mutation in codon 1755 and four other families shared a 2 bp deletion mutation in codons 22-23. These families were not known to be related, but haplotype analysis suggests that the carriers of each of these mutations have common ancestors. More... »

PAGES

392-398

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1294-392

DOI

http://dx.doi.org/10.1038/ng1294-392

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017336024

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7894492


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