The microRNA-producing enzyme Dicer1 is essential for zebrafish development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-10-05

AUTHORS

Erno Wienholds, Marco J Koudijs, Freek J M van Eeden, Edwin Cuppen, Ronald H A Plasterk

ABSTRACT

MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development. More... »

PAGES

217-218

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1251

DOI

http://dx.doi.org/10.1038/ng1251

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035759648

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14528306


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DEAD-box RNA Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endoribonucleases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Silencing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MicroRNAs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA Helicases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ribonuclease III", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zebrafish", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.419927.0", 
          "name": [
            "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wienholds", 
        "givenName": "Erno", 
        "id": "sg:person.01363751520.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363751520.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.419927.0", 
          "name": [
            "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koudijs", 
        "givenName": "Marco J", 
        "id": "sg:person.01223027347.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223027347.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.419927.0", 
          "name": [
            "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Eeden", 
        "givenName": "Freek J M", 
        "id": "sg:person.0735761433.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735761433.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.419927.0", 
          "name": [
            "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cuppen", 
        "givenName": "Edwin", 
        "id": "sg:person.01334303101.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334303101.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands", 
          "id": "http://www.grid.ac/institutes/grid.419927.0", 
          "name": [
            "Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Plasterk", 
        "givenName": "Ronald H A", 
        "id": "sg:person.01230321605.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230321605.78"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35053110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042658253", 
          "https://doi.org/10.1038/35053110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35002607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047689840", 
          "https://doi.org/10.1038/35002607"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-10-05", 
    "datePublishedReg": "2003-10-05", 
    "description": "MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ng1251", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "keywords": [
      "vertebrate development", 
      "role of Dicer1", 
      "miRNA accumulation", 
      "zebrafish development", 
      "enzyme Dicer1", 
      "developmental arrest", 
      "DICER1 mutant", 
      "miRNA levels", 
      "DICER1", 
      "DICER1 gene", 
      "zebrafish", 
      "mutants", 
      "genes", 
      "microRNAs", 
      "enzyme", 
      "inactivation", 
      "accumulation", 
      "arrest", 
      "development", 
      "role", 
      "day 10", 
      "levels", 
      "results", 
      "days"
    ], 
    "name": "The microRNA-producing enzyme Dicer1 is essential for zebrafish development", 
    "pagination": "217-218", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035759648"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng1251"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14528306"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng1251", 
      "https://app.dimensions.ai/details/publication/pub.1035759648"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_365.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ng1251"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng1251'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng1251'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng1251'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng1251'


 

This table displays all metadata directly associated to this object as RDF triples.

161 TRIPLES      21 PREDICATES      61 URIs      50 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng1251 schema:about N090e426ae318478fa21e8b347e16f27f
2 N248265de6a5046629e3c7ad49e22a4c1
3 N419fc19f6c134f8894ccdb6729557f6f
4 N5b85faf6ece947bc9bade5260edbe16e
5 N615ce8ce9c35449e99b00b6868cc13b8
6 N6c0fdda3c24e4a598840891a5b71e199
7 N8359749bc892475ab09a134abdaa9fea
8 Nb6468892b0b64d51836e89845c7bc8c2
9 Nf456499f4155411dbb5b1c7850cc91f5
10 anzsrc-for:06
11 anzsrc-for:0601
12 anzsrc-for:0604
13 schema:author N59c710fc5a274c4dbc77d1182eb07755
14 schema:citation sg:pub.10.1038/35002607
15 sg:pub.10.1038/35053110
16 schema:datePublished 2003-10-05
17 schema:datePublishedReg 2003-10-05
18 schema:description MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development.
19 schema:genre article
20 schema:isAccessibleForFree false
21 schema:isPartOf N255a66752708411da3e2e9bb7a374172
22 Nc68ca042b7d747029fd4ebebc02c642a
23 sg:journal.1103138
24 schema:keywords DICER1
25 DICER1 gene
26 DICER1 mutant
27 accumulation
28 arrest
29 day 10
30 days
31 development
32 developmental arrest
33 enzyme
34 enzyme Dicer1
35 genes
36 inactivation
37 levels
38 miRNA accumulation
39 miRNA levels
40 microRNAs
41 mutants
42 results
43 role
44 role of Dicer1
45 vertebrate development
46 zebrafish
47 zebrafish development
48 schema:name The microRNA-producing enzyme Dicer1 is essential for zebrafish development
49 schema:pagination 217-218
50 schema:productId N1e25493c2b304294ac57428bbe63e73d
51 N8bb2e5f9199f4c90b2cbb908a6f10587
52 Nf67a430d208b4c838ee2425dc39828f9
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035759648
54 https://doi.org/10.1038/ng1251
55 schema:sdDatePublished 2022-09-02T15:51
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N5d5942b1430e43f68be2f51ea43bc1a5
58 schema:url https://doi.org/10.1038/ng1251
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N090e426ae318478fa21e8b347e16f27f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Mutation
64 rdf:type schema:DefinedTerm
65 N1e25493c2b304294ac57428bbe63e73d schema:name doi
66 schema:value 10.1038/ng1251
67 rdf:type schema:PropertyValue
68 N1ff482bfa2e046c580d1eb9081f41ef8 rdf:first sg:person.0735761433.17
69 rdf:rest N7c4cb9ccf0044b0498daa036e39ed6b6
70 N248265de6a5046629e3c7ad49e22a4c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Animals
72 rdf:type schema:DefinedTerm
73 N255a66752708411da3e2e9bb7a374172 schema:volumeNumber 35
74 rdf:type schema:PublicationVolume
75 N419fc19f6c134f8894ccdb6729557f6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name DEAD-box RNA Helicases
77 rdf:type schema:DefinedTerm
78 N59c710fc5a274c4dbc77d1182eb07755 rdf:first sg:person.01363751520.39
79 rdf:rest Nbcd7c43b2f6347e38752ee75419f76c5
80 N5b85faf6ece947bc9bade5260edbe16e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Zebrafish
82 rdf:type schema:DefinedTerm
83 N5d5942b1430e43f68be2f51ea43bc1a5 schema:name Springer Nature - SN SciGraph project
84 rdf:type schema:Organization
85 N615ce8ce9c35449e99b00b6868cc13b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name MicroRNAs
87 rdf:type schema:DefinedTerm
88 N6c0fdda3c24e4a598840891a5b71e199 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Endoribonucleases
90 rdf:type schema:DefinedTerm
91 N7c4cb9ccf0044b0498daa036e39ed6b6 rdf:first sg:person.01334303101.27
92 rdf:rest Nf82fc2b2e5004f81abba75ceed83b4b3
93 N8359749bc892475ab09a134abdaa9fea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Gene Silencing
95 rdf:type schema:DefinedTerm
96 N8bb2e5f9199f4c90b2cbb908a6f10587 schema:name pubmed_id
97 schema:value 14528306
98 rdf:type schema:PropertyValue
99 Nb6468892b0b64d51836e89845c7bc8c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Ribonuclease III
101 rdf:type schema:DefinedTerm
102 Nbcd7c43b2f6347e38752ee75419f76c5 rdf:first sg:person.01223027347.16
103 rdf:rest N1ff482bfa2e046c580d1eb9081f41ef8
104 Nc68ca042b7d747029fd4ebebc02c642a schema:issueNumber 3
105 rdf:type schema:PublicationIssue
106 Nf456499f4155411dbb5b1c7850cc91f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name RNA Helicases
108 rdf:type schema:DefinedTerm
109 Nf67a430d208b4c838ee2425dc39828f9 schema:name dimensions_id
110 schema:value pub.1035759648
111 rdf:type schema:PropertyValue
112 Nf82fc2b2e5004f81abba75ceed83b4b3 rdf:first sg:person.01230321605.78
113 rdf:rest rdf:nil
114 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
115 schema:name Biological Sciences
116 rdf:type schema:DefinedTerm
117 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
118 schema:name Biochemistry and Cell Biology
119 rdf:type schema:DefinedTerm
120 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
121 schema:name Genetics
122 rdf:type schema:DefinedTerm
123 sg:journal.1103138 schema:issn 1061-4036
124 1546-1718
125 schema:name Nature Genetics
126 schema:publisher Springer Nature
127 rdf:type schema:Periodical
128 sg:person.01223027347.16 schema:affiliation grid-institutes:grid.419927.0
129 schema:familyName Koudijs
130 schema:givenName Marco J
131 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223027347.16
132 rdf:type schema:Person
133 sg:person.01230321605.78 schema:affiliation grid-institutes:grid.419927.0
134 schema:familyName Plasterk
135 schema:givenName Ronald H A
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230321605.78
137 rdf:type schema:Person
138 sg:person.01334303101.27 schema:affiliation grid-institutes:grid.419927.0
139 schema:familyName Cuppen
140 schema:givenName Edwin
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334303101.27
142 rdf:type schema:Person
143 sg:person.01363751520.39 schema:affiliation grid-institutes:grid.419927.0
144 schema:familyName Wienholds
145 schema:givenName Erno
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363751520.39
147 rdf:type schema:Person
148 sg:person.0735761433.17 schema:affiliation grid-institutes:grid.419927.0
149 schema:familyName van Eeden
150 schema:givenName Freek J M
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735761433.17
152 rdf:type schema:Person
153 sg:pub.10.1038/35002607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047689840
154 https://doi.org/10.1038/35002607
155 rdf:type schema:CreativeWork
156 sg:pub.10.1038/35053110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042658253
157 https://doi.org/10.1038/35053110
158 rdf:type schema:CreativeWork
159 grid-institutes:grid.419927.0 schema:alternateName Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands
160 schema:name Department of Functional Genomics, Hubrecht Laboratory, 3584 CT, Utrecht, The Netherlands
161 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...