Trinucleotide repeats affect DNA replication in vivo View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-11

AUTHORS

George M. Samadashwily, Gordana Raca, Sergei M. Mirkin

ABSTRACT

(CGG)n.(CCG)n and (CTG)n.(CAG)n repeats of varying length were cloned into a bacterial plasmid, and the progression of the replication fork through these repeats was followed using electrophoretic analysis of replication intermediates. We observed stalling of the replication fork within repeated DNAs and found that this effect depends on repeat length, repeat orientation relative to the replication origin and the status of protein synthesis in a cell. Interruptions within repeated DNAs, similar to those observed in human genes, abolished the replication blockage. Our results suggest that the formation of unusual DNA structures by trinucleotide repeats in the lagging-strand template may account for the observed replication blockage and have relevance to repeat expansion in humans. More... »

PAGES

298-304

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1197-298

DOI

http://dx.doi.org/10.1038/ng1197-298

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004060810

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9354793


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