Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results View Full Text


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Article Info

DATE

1995-11

AUTHORS

Eric Lander, Leonid Kruglyak

ABSTRACT

Genetic studies are under way for many complex traits, spurred by the recent feasibility of whole genome scans. Clear guidelines for the interpretation of linkage results are needed to avoid a flood of false positive claims. At the same time, an overly cautious approach runs the risk of causing true hints of linkage to be missed. We address this problem by proposing specific standards designed to maintain rigor while also promoting communication. More... »

PAGES

241-247

References to SciGraph publications

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  • 1974. Theoretical Statistics in NONE
  • 1988-11. Localization of a susceptibility locus for schizophrenia on chromosome 5 in NATURE
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  • 1995-11. An international two–stage genome–wide search for schizophrenia susceptibility genes in NATURE GENETICS
  • 1989-11. Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish in NATURE
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  • 1987-02. Bipolar affective disorders linked to DNA markers on chromosome 11 in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng1195-241

    DOI

    http://dx.doi.org/10.1038/ng1195-241

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040726560

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7581446


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