Expression of Xist in mouse germ cells correlates with X–chromosome inactivation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-11

AUTHORS

J R McCarrey, D D Dilworth

ABSTRACT

Mammals compensate for different doses of X-chromosome-linked genes in male (XY) and female (XX) somatic cells by terminally inactivating all but one X chromosome in each cell. A transiently inactive X chromosome is also found in germ cells, specifically in premeiotic oogenic cells and in meiotic and postmeiotic spermatogenic cells. Here we show that the Xist gene, which is a expressed predominantly from the inactive X-chromosome in female somatic cells, is also expressed in germ cells of both sexes, but only at those stages when an inactive X chromosome is present. This suggests support for the putative role of Xist as a regulator of X-chromosome inactivation and suggest a common mechanism for the initiation and/or maintenance of X-chromosome inactivation in all cell types. More... »

PAGES

200-203

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1192-200

DOI

http://dx.doi.org/10.1038/ng1192-200

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046586753

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1345169


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