X inactivation in mammalian testis is correlated with inactive X–specific transcription View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-11

AUTHORS

C Richler, H Soreq, J Wahrman

ABSTRACT

X chromosome inactivation occurs twice during the mammalian life cycle. In females one of the two X chromosomes of somatic nuclei is inactive, while in males the solitary X chromosome is inactivated during germ cell development. Despite the different properties of the inactivated chromosomes of females and males, the molecular initiation of inactivation may be the same. X inactive-specific transcripts, XIST, are produced from somatic inactivated X chromosomes. We demonstrate here the existence of XIST transcripts in testes of man and mouse. Inactivation of X chromosomes in males, as in females, may thus be mediated through XIST. Conceivably, the silencing of X-linked genes is the price paid for the evolution of successful mechanisms of chromosomal sex determination. More... »

PAGES

192-195

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng1192-192

DOI

http://dx.doi.org/10.1038/ng1192-192

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032119156

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1345167


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