Single pass sequencing and physical and genetic mapping of human brain cDNAs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1992-11

AUTHORS

A S Khan, A S Wilcox, M H Polymeropoulos, J A Hopkins, T J Stevens, M Robinson, A K Orpana, J M Sikela

ABSTRACT

We have performed single pass sequencing of 1,024 human brain cDNAs, over 900 of which seem to represent new human genes. Library prescreening with total brain cDNA significantly reduced repeated sequencing of highly represented cDNAs. A subset of sequenced cDNAs were physically mapped to their chromosomal locations using gene-specific STS primers derived from 3' untranslated regions. We have also determined that human brain cDNAs represent a rich source of gene-associated polymorphic markers. Microsatellite-containing cDNAs can be physically mapped and converted to highly informative genetic markers, thus facilitating integration of the human physical, expression and genetic maps. More... »

PAGES

180-185

Journal

TITLE

Nature Genetics

ISSUE

3

VOLUME

2

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng1192-180

    DOI

    http://dx.doi.org/10.1038/ng1192-180

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005408376

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/1345165


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