Induction of an interferon response by RNAi vectors in mammalian cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-07

AUTHORS

Alan J Bridge, Stephanie Pebernard, Annick Ducraux, Anne-Laure Nicoulaz, Richard Iggo

ABSTRACT

DNA vectors that express short hairpin RNAs (shRNAs) from RNA polymerase III (Pol III) promoters are a promising new tool to reduce gene expression in mammalian cells. shRNAs are processed to small interfering RNAs (siRNAs) of 21 nucleotides (nt) that guide the cleavage of the cognate mRNA by the RNA-induced silencing complex. Although siRNAs are thought to be too short to induce interferon expression, we report here that a substantial number of shRNA vectors can trigger an interferon response. More... »

PAGES

263-264

Journal

TITLE

Nature Genetics

ISSUE

3

VOLUME

34

Related Patents

  • Inhibition Of Viral Gene Expression Using Small Interfering Rna
  • Control Of Gene Expression
  • Methods Of Detecting Silencing Mammalian Cells
  • Bioinformatically Detectable Group Of Novel Regulatory Oligonucleotides And Uses Thereof
  • Method Of Stimulating An Immune Response And Inhibiting Expression Of A Gene Using An Oligonucleotide
  • Delivering Functional Nucleic Acids To Mammalian Cells Via Bacterially-Derived, Intact Minicells
  • Bacterially Derived Intact Minicells That Encompass Plasmid Free Functional Nucleic Acid For In Vivo Delivery To Mammalian Cells
  • Pharmaceutically Purified Intact Bacterial Minicells
  • Anti-Tumor Compositions And Methods
  • Delivering Functional Nucleic Acids To Mammalian Cells Via Bacterially-Derived, Intact Minicells
  • Control Of Gene Expression
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Bioinformatically Detectable Group Of Novel Regulatory Viral And Viral Associated Oligonucleotides And Uses Thereof
  • Sirna-Mediated Gene Silencing
  • Targeted Delivery Of Drugs, Therapeutic Nucleic Acids And Functional Nucleic Acids To Mammalian Cells Via Intact Killed Bacterial Cells
  • Rna Molecules And Vectors For Gene Silencing
  • Rnai Modulation Of Rsv And Therapeutic Uses Thereof
  • Synthetic Genes And Genetic Constructs
  • Rnai Modulation Of Rsv, Piv And Other Respiratory Viruses And Uses Thereof
  • Methods For Targeted In Vitro And In Vivo Drug Delivery To Mammalian Cells Via Bacterially Derived Intact Minicells
  • Modified Sirna Molecules And Uses Thereof
  • Viral And Viral Associated Mirnas And Uses Thereof
  • Rnai Modulation Of Rsv, Piv And Other Respiratory Viruses And Uses Thereof
  • Rnai Modulation Of Rsv And Therapeutic Uses Thereof
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Pharmaceutically Compatible Method For Purifying Intact Bacterial Minicells
  • Antiproliferative Agent
  • Methods For Determining Specificity Of Rna Silencing And For Genetic Analysis Of The Silenced Gene Or Protein
  • Rna Interference Mediating Small Rna Molecules
  • Rna Interference Mediating Small Rna Molecules
  • Rna Interference Mediating Small Rna Molecules
  • Modified Sirna Molecules And Uses Thereof
  • Chemical Modification Of Short Small Hairpin Rnas For Inhibition Of Gene Expression
  • Bioionformality Detectable Group Of Novel Regulatory Oligonucleotides And Uses Thereof
  • Post-Transcriptional Gene Silencing Using Expressed Double Stranded Rna
  • Bacterially Derived Intact Minicells That Encompass Plasmid Free Functional Nucleic Acid For In Vivo Delivery To Mammalian Cells
  • Rnai Modulation Of Rsv And Therapeutic Uses Thereof
  • Modified Sirna Molecules And Uses Thereof
  • Rnai Modulation Of Rsv And Therapeutic Uses Thereof
  • Rnai Modulation Of Rsv And Therapeutic Uses Thereof
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Pharmaceutical Compositions Comprising Purified Intact Bacterial Minicells
  • Bioinformatically Detectable Group Of Novel Regulatory Oligonucleotides And Uses Thereof
  • Methods And Products For Expression Of Micro Rnas
  • Rna Interference Mediating Small Rna Molecules
  • Double-Stranded And Single-Stranded Rna Molecules With 5′ Triphosphates And Their Use For Inducing Interferon
  • Inhibition Of Viral Gene Expression Using Small Interfering Rna
  • Rna Interference Mediating Small Rna Molecules
  • Targeted Delivery Of Drugs, Therapeutic Nucleic Acids And Functional Nucleic Acids To Mammalian Cells Via Intact Killed Bacterial Cells
  • Double-Stranded And Single-Stranded Rna Molecules With 5′ Triphosphates And Their Use For Inducing Interferon
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Compositions Comprising Immunostimulatory Sirna Molecules And Dlindma Or Dlendma
  • Small Molecules Modulating Activity Of Micro Rna Oligonucleotides And Micro Rna Targets And Uses Thereof
  • Bacterially Derived Intact Minicells That Encompass Plasmid Free Functional Nucleic Acid For In Vivo Delivery To Mammalian Cells
  • Chemical Modification Of Short Small Hairpin Rnas For Inhibition Of Gene Expression
  • Rna Interference Mediating Small Rna Molecules
  • Viral And Viral Associated Mirnas And Uses Thereof
  • Double-Stranded And Single-Stranded Rna Molecules With 5′ Triphosphates And Their Use For Inducing Interferon
  • Rnai Modulation Of Rsv, Piv And Other Respiratory Viruses And Uses Thereof
  • Inducible Systems And Methods For Controlling Sirna Expression
  • Compositions For Bacterial Mediated Gene Silencing And Methods Of Using Same
  • Rna Interference Mediating Small Rna Molecules
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Methods For Targeted In Vitro And In Vivo Drug Delivery To Mammalian Cells Via Bacterially Derived Intact Minicells
  • Short Hairpin Rnas For Inhibition Of Gene Expression
  • Rna Interference Mediating Small Rna Molecules
  • Bacteria Mediated Gene Silencing
  • Rna Interference Mediating Small Rna Molecules
  • Modified Sirna Molecules And Uses Thereof
  • Rna Interference Mediating Small Rna Molecules
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Bacterially-Derived, Intact Minicells That Encompass Plasmid-Free Functional Nucleic Acid For In Vivo Delivery To Mammalian Cells
  • Rna Interference Mediating Small Rna Molecules
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Sirna-Mediated Gene Silencing
  • Methods And Products For Expression Of Micro Rnas
  • Micrornas And Uses Thereof
  • Short Hairpin Rnas For Inhibition Of Gene Expression
  • Sirna-Mediated Gene Silencing
  • Rna Sequence-Specific Mediators Of Rna Interference
  • Sequence-Specific Inhibition Of Small Rna Function
  • Modified Sirna Molecules And Uses Thereof
  • Bioinformatically Detectable Group Of Novel Regulatory Genes And Uses Thereof
  • Sequence-Specific Inhibition Of Small Rna Function
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng1173

    DOI

    http://dx.doi.org/10.1038/ng1173

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1000001349

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12796781


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "2',5'-Oligoadenylate Synthetase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enzyme Induction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fibroblasts", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Vectors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HeLa Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lentivirus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lung", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Promoter Regions, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA Polymerase III", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Small Interfering", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcription, Genetic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transfection", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
              "id": "https://www.grid.ac/institutes/grid.5333.6", 
              "name": [
                "Swiss Institute for Experimental Cancer Research, CH-1066 Epalinges, Switzerland."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bridge", 
            "givenName": "Alan J", 
            "id": "sg:person.01343464646.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343464646.44"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Pebernard", 
            "givenName": "Stephanie", 
            "id": "sg:person.01207066367.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207066367.29"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Ducraux", 
            "givenName": "Annick", 
            "id": "sg:person.01232524455.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232524455.74"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Nicoulaz", 
            "givenName": "Anne-Laure", 
            "id": "sg:person.01165773436.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165773436.45"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Iggo", 
            "givenName": "Richard", 
            "id": "sg:person.01140527651.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140527651.89"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1126/science.1068999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020993705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026483107", 
              "https://doi.org/10.1038/77558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026483107", 
              "https://doi.org/10.1038/77558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.2.1479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029025188"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.22.22.7868-7876.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043872426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.7.1.549", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049536085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.272.5259.263", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062552729"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2003-07", 
        "datePublishedReg": "2003-07-01", 
        "description": "DNA vectors that express short hairpin RNAs (shRNAs) from RNA polymerase III (Pol III) promoters are a promising new tool to reduce gene expression in mammalian cells. shRNAs are processed to small interfering RNAs (siRNAs) of 21 nucleotides (nt) that guide the cleavage of the cognate mRNA by the RNA-induced silencing complex. Although siRNAs are thought to be too short to induce interferon expression, we report here that a substantial number of shRNA vectors can trigger an interferon response.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ng1173", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1103138", 
            "issn": [
              "1061-4036", 
              "1546-1718"
            ], 
            "name": "Nature Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "34"
          }
        ], 
        "name": "Induction of an interferon response by RNAi vectors in mammalian cells", 
        "pagination": "263-264", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0001a67fac0a4af40ecbd6c423ac509927e2711522c9d239e3a17fb08e650047"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "12796781"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9216904"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ng1173"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1000001349"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ng1173", 
          "https://app.dimensions.ai/details/publication/pub.1000001349"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:13", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000361_0000000361/records_53998_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/ng/journal/v34/n3/full/ng1173.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng1173'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng1173'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng1173'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng1173'


     

    This table displays all metadata directly associated to this object as RDF triples.

    176 TRIPLES      21 PREDICATES      51 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ng1173 schema:about N0190d601d80b4f7e98acecb2494cb3a3
    2 N11135d2251f84807aa7ebc29460b2e33
    3 N17dde8bad4274aef9fc3e3580cf05075
    4 N1ae738bf9ada4dfc852c61d97ea6485d
    5 N1cff37ddee424023bdfb4e863af5483c
    6 N2a9720a453d5452ab6100395b246be93
    7 N2aebde12d18d47588e73b84f0522a093
    8 N6c86bb3e4dfe43bc8bc8c091667b502a
    9 N7bfedda931ad4057ac92a2b5133cb8c5
    10 N88c683d325e24e03a383cd23b832365b
    11 N9aa2398aa767405a989f1cb9c84db94c
    12 Nba3e86350da3470cbab15722988a8c7a
    13 Ncc9af72d849445da8b7b1c6bf446c15f
    14 Ndab75d38872c4b20b3bd136ebe23d202
    15 Ne023e413dd264f6bac45f8bc10101ae4
    16 Ne6a907ae0b724c9c9a75cac88c52c0bc
    17 anzsrc-for:06
    18 anzsrc-for:0604
    19 schema:author Nf37abf0a52d041e88e98ef38e4eef385
    20 schema:citation sg:pub.10.1038/77558
    21 https://doi.org/10.1126/science.1068999
    22 https://doi.org/10.1126/science.272.5259.263
    23 https://doi.org/10.1128/mcb.19.2.1479
    24 https://doi.org/10.1128/mcb.22.22.7868-7876.2002
    25 https://doi.org/10.1128/mcb.7.1.549
    26 schema:datePublished 2003-07
    27 schema:datePublishedReg 2003-07-01
    28 schema:description DNA vectors that express short hairpin RNAs (shRNAs) from RNA polymerase III (Pol III) promoters are a promising new tool to reduce gene expression in mammalian cells. shRNAs are processed to small interfering RNAs (siRNAs) of 21 nucleotides (nt) that guide the cleavage of the cognate mRNA by the RNA-induced silencing complex. Although siRNAs are thought to be too short to induce interferon expression, we report here that a substantial number of shRNA vectors can trigger an interferon response.
    29 schema:genre research_article
    30 schema:inLanguage en
    31 schema:isAccessibleForFree false
    32 schema:isPartOf N9f9904e3c3f44f6e856283b0946bfa1c
    33 Na1c7133b76a34ef19f9c8435e0fe075f
    34 sg:journal.1103138
    35 schema:name Induction of an interferon response by RNAi vectors in mammalian cells
    36 schema:pagination 263-264
    37 schema:productId N2b357280fd4f4d528db4a179e31c244a
    38 N5d00a251146f41f4ba067da0b397c295
    39 N5fa6536377db47dfa4c7ed7de5a052f5
    40 N6b61531445414c21b73cae0ab40db665
    41 N9084d131d1cf489caf14f75686c23028
    42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000001349
    43 https://doi.org/10.1038/ng1173
    44 schema:sdDatePublished 2019-04-11T12:13
    45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    46 schema:sdPublisher N03bc0f01e6d843ee94beae26a9a0e8e0
    47 schema:url http://www.nature.com/ng/journal/v34/n3/full/ng1173.html
    48 sgo:license sg:explorer/license/
    49 sgo:sdDataset articles
    50 rdf:type schema:ScholarlyArticle
    51 N0190d601d80b4f7e98acecb2494cb3a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    52 schema:name Transfection
    53 rdf:type schema:DefinedTerm
    54 N03bc0f01e6d843ee94beae26a9a0e8e0 schema:name Springer Nature - SN SciGraph project
    55 rdf:type schema:Organization
    56 N11135d2251f84807aa7ebc29460b2e33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    57 schema:name Enzyme Induction
    58 rdf:type schema:DefinedTerm
    59 N17dde8bad4274aef9fc3e3580cf05075 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    60 schema:name Humans
    61 rdf:type schema:DefinedTerm
    62 N1a407ec9e3b9401a8f904b12bbfae014 rdf:first sg:person.01232524455.74
    63 rdf:rest N91c42c1aed73476e99bb64c42b254f49
    64 N1ae738bf9ada4dfc852c61d97ea6485d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    65 schema:name RNA
    66 rdf:type schema:DefinedTerm
    67 N1cff37ddee424023bdfb4e863af5483c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    68 schema:name RNA, Small Interfering
    69 rdf:type schema:DefinedTerm
    70 N2a9720a453d5452ab6100395b246be93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    71 schema:name Promoter Regions, Genetic
    72 rdf:type schema:DefinedTerm
    73 N2aebde12d18d47588e73b84f0522a093 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    74 schema:name HeLa Cells
    75 rdf:type schema:DefinedTerm
    76 N2b357280fd4f4d528db4a179e31c244a schema:name nlm_unique_id
    77 schema:value 9216904
    78 rdf:type schema:PropertyValue
    79 N35ae82ef97ba42078afe03e0f9ce9198 rdf:first sg:person.01207066367.29
    80 rdf:rest N1a407ec9e3b9401a8f904b12bbfae014
    81 N54890345b2de4e3fbbed37bcd7281925 rdf:first sg:person.01140527651.89
    82 rdf:rest rdf:nil
    83 N5d00a251146f41f4ba067da0b397c295 schema:name pubmed_id
    84 schema:value 12796781
    85 rdf:type schema:PropertyValue
    86 N5fa6536377db47dfa4c7ed7de5a052f5 schema:name doi
    87 schema:value 10.1038/ng1173
    88 rdf:type schema:PropertyValue
    89 N6b61531445414c21b73cae0ab40db665 schema:name dimensions_id
    90 schema:value pub.1000001349
    91 rdf:type schema:PropertyValue
    92 N6c86bb3e4dfe43bc8bc8c091667b502a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name RNA Polymerase III
    94 rdf:type schema:DefinedTerm
    95 N7bfedda931ad4057ac92a2b5133cb8c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Fibroblasts
    97 rdf:type schema:DefinedTerm
    98 N88c683d325e24e03a383cd23b832365b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Lung
    100 rdf:type schema:DefinedTerm
    101 N9084d131d1cf489caf14f75686c23028 schema:name readcube_id
    102 schema:value 0001a67fac0a4af40ecbd6c423ac509927e2711522c9d239e3a17fb08e650047
    103 rdf:type schema:PropertyValue
    104 N91c42c1aed73476e99bb64c42b254f49 rdf:first sg:person.01165773436.45
    105 rdf:rest N54890345b2de4e3fbbed37bcd7281925
    106 N9aa2398aa767405a989f1cb9c84db94c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name 2',5'-Oligoadenylate Synthetase
    108 rdf:type schema:DefinedTerm
    109 N9f9904e3c3f44f6e856283b0946bfa1c schema:volumeNumber 34
    110 rdf:type schema:PublicationVolume
    111 Na1c7133b76a34ef19f9c8435e0fe075f schema:issueNumber 3
    112 rdf:type schema:PublicationIssue
    113 Nba3e86350da3470cbab15722988a8c7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Transcription, Genetic
    115 rdf:type schema:DefinedTerm
    116 Ncc9af72d849445da8b7b1c6bf446c15f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Genetic Vectors
    118 rdf:type schema:DefinedTerm
    119 Ndab75d38872c4b20b3bd136ebe23d202 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Lentivirus
    121 rdf:type schema:DefinedTerm
    122 Ne023e413dd264f6bac45f8bc10101ae4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Interferons
    124 rdf:type schema:DefinedTerm
    125 Ne6a907ae0b724c9c9a75cac88c52c0bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Transcription Factors
    127 rdf:type schema:DefinedTerm
    128 Nf37abf0a52d041e88e98ef38e4eef385 rdf:first sg:person.01343464646.44
    129 rdf:rest N35ae82ef97ba42078afe03e0f9ce9198
    130 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    131 schema:name Biological Sciences
    132 rdf:type schema:DefinedTerm
    133 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    134 schema:name Genetics
    135 rdf:type schema:DefinedTerm
    136 sg:journal.1103138 schema:issn 1061-4036
    137 1546-1718
    138 schema:name Nature Genetics
    139 rdf:type schema:Periodical
    140 sg:person.01140527651.89 schema:familyName Iggo
    141 schema:givenName Richard
    142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140527651.89
    143 rdf:type schema:Person
    144 sg:person.01165773436.45 schema:familyName Nicoulaz
    145 schema:givenName Anne-Laure
    146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165773436.45
    147 rdf:type schema:Person
    148 sg:person.01207066367.29 schema:familyName Pebernard
    149 schema:givenName Stephanie
    150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207066367.29
    151 rdf:type schema:Person
    152 sg:person.01232524455.74 schema:familyName Ducraux
    153 schema:givenName Annick
    154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232524455.74
    155 rdf:type schema:Person
    156 sg:person.01343464646.44 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
    157 schema:familyName Bridge
    158 schema:givenName Alan J
    159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343464646.44
    160 rdf:type schema:Person
    161 sg:pub.10.1038/77558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026483107
    162 https://doi.org/10.1038/77558
    163 rdf:type schema:CreativeWork
    164 https://doi.org/10.1126/science.1068999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020993705
    165 rdf:type schema:CreativeWork
    166 https://doi.org/10.1126/science.272.5259.263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552729
    167 rdf:type schema:CreativeWork
    168 https://doi.org/10.1128/mcb.19.2.1479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029025188
    169 rdf:type schema:CreativeWork
    170 https://doi.org/10.1128/mcb.22.22.7868-7876.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043872426
    171 rdf:type schema:CreativeWork
    172 https://doi.org/10.1128/mcb.7.1.549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049536085
    173 rdf:type schema:CreativeWork
    174 https://www.grid.ac/institutes/grid.5333.6 schema:alternateName École Polytechnique Fédérale de Lausanne
    175 schema:name Swiss Institute for Experimental Cancer Research, CH-1066 Epalinges, Switzerland.
    176 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...