Natural variation in human gene expression assessed in lymphoblastoid cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-03

AUTHORS

Vivian G Cheung, Laura K Conlin, Teresa M Weber, Melissa Arcaro, Kuang-Yu Jen, Michael Morley, Richard S Spielman

ABSTRACT

The sequencing of the human genome has resulted in greater attention to genetic variation among individuals, and variation at the DNA sequence level is now being extensively studied. At the same time, it has become possible to study variation at the level of gene expression by various methods. At present, it is largely unknown how widespread this variation in transcript levels is over the entire genome and to what extent individual differences in expression level are genetically determined. In the present study, we used lymphoblastoid cells to examine variation in gene expression and identified genes whose transcript levels differed greatly among unrelated individuals. We also found evidence for familial aggregation of expression phenotype by comparing variation among unrelated individuals, among siblings within families and between monozygotic twins. These observations suggest that there is a genetic contribution to polymorphic variation in the level of gene expression. More... »

PAGES

422-425

Journal

TITLE

Nature Genetics

ISSUE

3

VOLUME

33

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng1094

    DOI

    http://dx.doi.org/10.1038/ng1094

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013710656

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12567189


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