Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-09

AUTHORS

C Caldas, S A Hahn, L T da Costa, M S Redston, M Schutte, A B Seymour, C L Weinstein, R H Hruban, C J Yeo, S E Kern

ABSTRACT

The MTS1 gene on chromosome 9p21 encodes the p16 inhibitor of cyclinD/Cdk-4 complexes, and is deleted or mutated in a variety of tumour types. We found allelic deletions of 9p21-p22 in 85% of pancreatic adenocarcinomas. Analysis of MTS1 in pancreatic carcinomas (27 xenografts and 10 cell lines) showed homozygous deletions in 15 (41%) and sequence changes in 14 (38%). These included eight point mutations (four nonsense, two missense and two splice site mutations) and six deletions/insertions, all accompanied by loss of the wild-type allele. Sequencing of MTS1 from primary tumours confirmed the mutations. Coexistent inactivations of both MTS1 and p53 was common and suggests that abnormal regulation of cyclin-dependent kinases may play an important role in the biology of pancreatic carcinoma. More... »

PAGES

27-32

Journal

TITLE

Nature Genetics

ISSUE

1

VOLUME

8

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng0994-27

    DOI

    http://dx.doi.org/10.1038/ng0994-27

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046920232

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7726912


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