Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-08

AUTHORS

Eric F.P.M. Schoenmakers, Sylke Wanschura, Raf Mols, Jörn Bullerdiek, Herman Van den Berghe, Wim J.M. Van de Ven

ABSTRACT

We recently showed that the 1.7 megabase multiple aberration region (MAR) on human chromosome 12q15 harbours recurrent breakpoints frequently found in a variety of benign solid tumours. We now report a candidate gene within MAR suspected to be of pathogenetical relevance. Using positional cloning, we have identified the high mobility group protein gene HMGI–C within a 175 kilobase segment of MAR and characterized its genomic organization. By FISH analysis, we show the majority of the breakpoints of eight different benign solid tumour types fall within this gene. By Southern blot and 3′–RACE analysis, we demonstrate consistent rearrangements in HMGI–C and/or expression of altered HMGI–C transcripts. These results suggest a link between a member of the HMG gene family and benign solid tumour development. More... »

PAGES

436-444

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0895-436

DOI

http://dx.doi.org/10.1038/ng0895-436

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042526375

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7670494


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