The murine Xe169 gene escapes X–inactivation like its human homologue View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-08

AUTHORS

J Wu, E C Salido, P H Yen, T K Mohandas, H H Heng, L C Tsui, J Park, V M Chapman, L J Shapiro

ABSTRACT

Among a number of genes that escape X-chromosome inactivation in humans, three have been evaluated in mice and unexpectedly all three are subject to X-inactivation. We report here the cloning and expression studies of a novel mouse gene, Xe169, and show that it escapes X-inactivation like its human homologue. Xe169 was assigned to band F2/F3 on the mouse X chromosome by fluorescent in situ hybridization and Southern analysis indicates that the gene is located outside the pseudoautosomal region. Homologous, but divergent, sequences exist on the Y chromosome. In vitro and in vivo studies show that Xe169 is expressed from both the active and the inactive X chromosomes. Xe169 is the first cloned non-pseudoautosomal gene that escapes X-inactivation in mice. More... »

PAGES

491

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0894-491

DOI

http://dx.doi.org/10.1038/ng0894-491

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029135613

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7951318


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