Polygenic control of autoimmune diabetes in nonobese diabetic mice View Full Text


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Article Info

DATE

1993-08

AUTHORS

S. Ghosh, S.M. Palmer, N.R. Rodrigues, H.J. Cordell, C.M. Hearne, R.J. Cornall, J.-B. Prins, P. McShane, G.M. Lathrop, L.B. Peterson, L.S. Wicker, J.A. Todd

ABSTRACT

Partial exclusion mapping of the nonobese (NOD) diabetic mouse genome has shown linkage of diabetes to at least five different chromosomes. We have now excluded almost all of the genome for the presence of susceptibility genes with fully recessive effects and have obtained evidence of linkage of ten distinct loci to diabetes or the prediabetic lesion, insulitis, indicative of a polygenic mode of inheritance. The relative importance of these loci and their interactions have been assessed using a new application of multiple polychotomous regression methods. A candidate disease gene, interleukin-2 (Il-2), which is closely linked to insulitis and diabetes, is shown to have a different sequence in NOD, including an insertion and a deletion of tandem repeat sequences which encode amino acid repeats in the mature protein. More... »

PAGES

404-409

References to SciGraph publications

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  • 1991-11. Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility in NATURE
  • 1986-03. Cloning and structure of a mouse interleukin-2 chromosomal gene in MOLECULAR BIOLOGY REPORTS
  • 1991-12. Mononucleotide repeats are an abundant source of length variants in mouse genomic DNA in MAMMALIAN GENOME
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  • 1991-09. Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice in NATURE
  • 1991-06. Genetic analysis of autoimmune type 1 diabetes mellitus in mice in NATURE
  • 1992-11. Human genes containing polymorphic trinucleotide repeats in NATURE GENETICS
  • 1988-10. Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms in NATURE
  • 1992-08. Linkage analysis of 84 microsatellite markers in intra- and interspecific backcrosses in MAMMALIAN GENOME
  • 1987-10. HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus in NATURE
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng0893-404

    DOI

    http://dx.doi.org/10.1038/ng0893-404

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028618389

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8401590


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    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng0893-404'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng0893-404'


     

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