Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-08

AUTHORS

Russell G. Snell, John C. MacMillan, Jeremy P. Cheadle, Iain Fenton, Lazarus P. Lazarou, Peter Davies, Marcy E. MacDonald, James F. Gusella, Peter S. Harper, Duncan J. Shaw

ABSTRACT

The molecular analysis of a specific CAG repeat sequence in the Huntington's disease gene in 440 Huntington's disease patients and 360 normal controls reveals a range of 30–70 repeats in affected individuals and 9–34 in normals. We find significant negative correlations between the number of repeats on the HD chromosome and age at onset, regardless of sex of the transmitting parent, and between the number of repeats on the normal paternal allele and age at onset in individuals with maternally transmitted disease. This effect of the normal paternal allele may account for the weaker age at onset correlation between affected sib pairs with disease of maternal as opposed to paternal origin and suggests that normal gene function varies because of the size of the repeat in the normal range and a sex–specific modifying effect. More... »

PAGES

393-397

Journal

TITLE

Nature Genetics

ISSUE

4

VOLUME

4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0893-393

DOI

http://dx.doi.org/10.1038/ng0893-393

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018721600

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8401588


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