Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-07

AUTHORS

M Sundvall, J Jirholt, H T Yang, L Jansson, A Engström, U Pettersson, R Holmdahl

ABSTRACT

B10.RIII mice develop chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with the myelin basic protein (MBP) peptide 89-101. The disease is associated with the major histocompatibility complex (MHC) (eae1). We have now investigated the importance of non-MHC regions for the EAE susceptibility in a cross between RIIIS/J and B10.RIII mice which share the MHC region but differ in disease susceptibility. Linkage analysis using microsatellite markers spanning the genome identified a region (eae2) on chromosome 15 which showed linkage to disease (P = 0.0002). Our data also suggest linkage to a second region (eae3) on chromosome 3 (P = 0.0024), and provide evidence for locus interactions between eae2 and eae3. These results provide clues to the genetic basis of multiple sclerosis. More... »

PAGES

313-317

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0795-313

DOI

http://dx.doi.org/10.1038/ng0795-313

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038086584

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7545492


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