A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-06

AUTHORS

C L Hanis, E Boerwinkle, R Chakraborty, D L Ellsworth, P Concannon, B Stirling, V A Morrison, B Wapelhorst, R S Spielman, K J Gogolin-Ewens, J M Shepard, S R Williams, N Risch, D Hinds, N Iwasaki, M Ogata, Y Omori, C Petzold, H Rietzch, H E Schröder, J Schulze, N J Cox, S Menzel, V V Boriraj, X Chen, L R Lim, T Lindner, L E Mereu, Y Q Wang, K Xiang, K Yamagata, Y Yang, G I Bell

ABSTRACT

Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non-and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1. More... »

PAGES

161-166

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0696-161

DOI

http://dx.doi.org/10.1038/ng0696-161

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038592318

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8640221


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JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng0696-161'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng0696-161'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng0696-161'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng0696-161'


 

This table displays all metadata directly associated to this object as RDF triples.

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