Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-06

AUTHORS

Uwe Rudolph, Milton J. Finegold, Susan S. Rich, Gregory R. Harriman, Yogambal Srinivasan, Philippe Brabet, Guylain Boulay, Allan Bradley, Lutz Birnbaumer

ABSTRACT

G proteins are involved in cellular signalling and regulate a variety of biological processes including differentiation and development. We have generated mice deficient for the G protein subunit αi2 (Gαi2) by homologous recombination in embryonic stem cells. Gαi2–deficient mice display growth retardation and develop a lethal diffuse colitis with clinical and histopathological features closely resembling ulcerative colitis in humans, including the development of adenocarcinoma of the colon. Prior to clinical symptoms, the mice show profound alterations in thymocyte maturation and function. The study of these animals should provide important insights into the pathogenesis of ulcerative colitis as well as carcinogenesis. More... »

PAGES

143-150

Journal

TITLE

Nature Genetics

ISSUE

2

VOLUME

10

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0695-143

DOI

http://dx.doi.org/10.1038/ng0695-143

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041040361

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7663509


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