SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-05

AUTHORS

Hirohide Yoshikawa, Kenichi Matsubara, Geng-Sun Qian, Peta Jackson, John D. Groopman, Jasper E. Manning, Curtis C. Harris, James G. Herman

ABSTRACT

Hepatocellular carcinoma (HCC) is a major cause of cancer death, but the molecular mechanism for its development beyond its initiation has not been well characterized. Suppressor of cytokine signaling (SOCS-1; also known as JAB and SSI-1) switches cytokine signaling 'off' by means of its direct interaction with Janus kinase (JAK). We identified aberrant methylation in the CpG island of SOCS-1 that correlated with its transcription silencing in HCC cell lines. The incidence of aberrant methylation was 65% in the 26 human primary HCC tumor samples analyzed. Moreover, the restoration of SOCS-1 suppressed both growth rate and anchorage-independent growth of cells in which SOCS-1 was methylation-silenced and JAK2 was constitutively activated. This growth suppression was caused by apoptosis and was reproduced by AG490, a specific, chemical JAK2 inhibitor that reversed constitutive phosphorylation of STAT3 in SOCS-1 inactivated cells. The high prevalence of the aberrant SOCS-1 methylation and its growth suppression activity demonstrated the importance of the constitutive activation of the JAK/STAT pathway in the development of HCC. Our results also indicate therapeutic strategies for the treatment of HCC including use of SOCS-1 in gene therapy and inhibition of JAK2 by small molecules, such as AG490. More... »

PAGES

29-35

Journal

TITLE

Nature Genetics

ISSUE

1

VOLUME

28

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0501-29

DOI

http://dx.doi.org/10.1038/ng0501-29

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003632653

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11326271


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