Human gene targeting by viral vectors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1998-04

AUTHORS

D W Russell, R K Hirata

ABSTRACT

Stable transduction of mammalian cells typically involves random integration of viral vectors by non-homologous recombination. Here we report that vectors based on adeno-associated virus (AAV) can efficiently modify homologous human chromosomal target sequences. Both integrated neomycin phosphotransferase genes and the hypoxanthine phosphoribosyltransferase gene were targeted by AAV vectors. Site-specific genetic modifications could be introduced into approximately 1% of cells, with the highest targeting rates occurring in normal human fibroblasts. These results suggest that AAV vectors could be used to introduce specific genetic changes into the genomic DNA of a wide variety of mammalian cells, including therapeutic gene targeting applications. More... »

PAGES

325-330

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0498-325

DOI

http://dx.doi.org/10.1038/ng0498-325

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011487372

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9537413


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