Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-04

AUTHORS

P A Steck, M A Pershouse, S A Jasser, W K Yung, H Lin, A H Ligon, L A Langford, M L Baumgard, T Hattier, T Davis, C Frye, R Hu, B Swedlund, D H Teng, S V Tavtigian

ABSTRACT

Deletions involving regions of chromosome 10 occur in the vast majority (> 90%) of human glioblastoma multiformes. A region at chromosome 10q23-24 was implicated to contain a tumour suppressor gene and the identification of homozygous deletions in four glioma cell lines further refined the location. We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA. The predicted MMAC1 protein contains sequence motifs with significant homology to the catalytic domain of protein phosphatases and to the cytoskeletal proteins, tensin and auxilin. MMAC1 coding-region mutations were observed in a number of glioma, prostate, kidney and breast carcinoma cell lines or tumour specimens. Our results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers. More... »

PAGES

356-362

Journal

TITLE

Nature Genetics

ISSUE

4

VOLUME

15

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng0497-356

    DOI

    http://dx.doi.org/10.1038/ng0497-356

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048219802

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9090379


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