Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-04

AUTHORS

Peter A. Steck, Mark A. Pershouse, Samar A. Jasser, W.K. Alfred Yung, Huai Lin, Azra H. Ligon, Lauren A. Langford, Michelle L. Baumgard, Thomas Hattier, Thaylon Davis, Cheryl Frye, Rong Hu, Bradley Swedlund, David H.R. Teng, Sean V. Tavtigian

ABSTRACT

Deletions involving regions of chromosome 10 occur in the vast majority (>90%) of human glioblastoma multiformes. A region at chromosome 10q23–24 was implicated to contain a tumour suppressor gene and the identification of homozygous deletions in four glioma cell lines further refined the location. We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA. The predicted MMAC1 protein contains sequence motifs with significant homology to the catalytic domain of protein phosphatases and to the cytoskeletal proteins, tensin and auxilin. MMAC1 coding-region mutations were observed in a number of glioma, prostate, kidney and breast carcinoma cell lines or tumour specimens. Our results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers. More... »

PAGES

356-362

Journal

TITLE

Nature Genetics

ISSUE

4

VOLUME

15

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng0497-356

    DOI

    http://dx.doi.org/10.1038/ng0497-356

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1048219802

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9090379


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    344 schema:name Myriad Genetics Inc., 390 Wakara Way, 84108, Salt Lake City, Utah, USA
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