The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-04

AUTHORS

C Li, M Ramjeesingh, E Reyes, T Jensen, X Chang, J M Rommens, C E Bear

ABSTRACT

The cystic fibrosis transmembrane conductance regulator (CFTR) is a phosphorylation-regulated Cl- channel. In most mammalian cells, the functional consequences of the most common CF mutation, delta F508-CFTR, cannot be assessed as the mutant protein undergoes biosynthetic arrest. However, function can be studied in the baculovirus-insect cell expression system where delta F508-CFTR does not appear to undergo such arrest. Our results show that phosphorylation-regulated Cl- channel activity of delta F508-CFTR is similar to that of wild-type CFTR. This observation was confirmed in comparative studies of purified delta F508-CFTR and CFTR reconstituted in planar lipid bilayers. Therefore, we suggest that this common mutation does not result in a significant alteration in CFTR function. More... »

PAGES

311-316

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0493-311

DOI

http://dx.doi.org/10.1038/ng0493-311

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026638555

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7526932


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CHO Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chloride Channels", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cricetinae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystic Fibrosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystic Fibrosis Transmembrane Conductance Regulator", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipid Bilayers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Potentials", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenylalanine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Folding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spodoptera", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital for Sick Children", 
          "id": "https://www.grid.ac/institutes/grid.42327.30", 
          "name": [
            "Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "C", 
        "id": "sg:person.01175351322.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175351322.43"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ramjeesingh", 
        "givenName": "M", 
        "id": "sg:person.01243014415.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243014415.40"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Reyes", 
        "givenName": "E", 
        "id": "sg:person.0761067124.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761067124.12"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Jensen", 
        "givenName": "T", 
        "id": "sg:person.016360211272.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016360211272.02"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Chang", 
        "givenName": "X", 
        "id": "sg:person.01310536143.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310536143.87"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Rommens", 
        "givenName": "J M", 
        "id": "sg:person.01355172356.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355172356.46"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Bear", 
        "givenName": "C E", 
        "id": "sg:person.01251134606.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251134606.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90498-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001366314"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/346366a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005574691", 
          "https://doi.org/10.1038/346366a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/358761a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009186996", 
          "https://doi.org/10.1038/358761a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/227680a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010419937", 
          "https://doi.org/10.1038/227680a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00656997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014806333", 
          "https://doi.org/10.1007/bf00656997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00656997", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014806333", 
          "https://doi.org/10.1007/bf00656997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-3495(90)82429-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015738041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/354526a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018163170", 
          "https://doi.org/10.1038/354526a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.21.8447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018923177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.11.8.3886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024866989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90148-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031197376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(92)90196-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035841266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0892-321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039691323", 
          "https://doi.org/10.1038/ng0892-321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90072-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040830484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(77)90043-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043533757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/352628a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044633103", 
          "https://doi.org/10.1038/352628a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90155-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047418822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.118.3.551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052204146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/346362a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052799411", 
          "https://doi.org/10.1038/346362a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1722350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062503030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2475911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062539396"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2570460", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062544667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1992.262.1.c251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075951053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075965441", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075967631", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078294328", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1993-04", 
    "datePublishedReg": "1993-04-01", 
    "description": "The cystic fibrosis transmembrane conductance regulator (CFTR) is a phosphorylation-regulated Cl- channel. In most mammalian cells, the functional consequences of the most common CF mutation, delta F508-CFTR, cannot be assessed as the mutant protein undergoes biosynthetic arrest. However, function can be studied in the baculovirus-insect cell expression system where delta F508-CFTR does not appear to undergo such arrest. Our results show that phosphorylation-regulated Cl- channel activity of delta F508-CFTR is similar to that of wild-type CFTR. This observation was confirmed in comparative studies of purified delta F508-CFTR and CFTR reconstituted in planar lipid bilayers. Therefore, we suggest that this common mutation does not result in a significant alteration in CFTR function.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng0493-311", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "name": "The cystic fibrosis mutation (\u0394F508) does not influence the chloride channel activity of CFTR", 
    "pagination": "311-316", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7ee73b0ebcddff5dca82b02e5da4d9914576e1521340d63a59d383b205f87f21"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7526932"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng0493-311"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026638555"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng0493-311", 
      "https://app.dimensions.ai/details/publication/pub.1026638555"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ng0493-311"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng0493-311'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng0493-311'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng0493-311'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng0493-311'


 

This table displays all metadata directly associated to this object as RDF triples.

277 TRIPLES      21 PREDICATES      77 URIs      44 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng0493-311 schema:about N017fbc9649b143e8ba893a78e3b0dd06
2 N1bdbaa21687a4b27bbd68b6011f24f08
3 N1e3215cc46754729ac048de51de10d8d
4 N27b5a1c8f7e44066aeeade190ba6d946
5 N2f14d3ca70014fceaff684c810f1d822
6 N4b15c038ca194f529f07d1ceadca3b01
7 N4b3332f760644f2993fc8741d21e327f
8 N5bd49fdcc87a4390a89b5404f62b442a
9 N5e620e5d95c04cb28af10a06c646fb30
10 N6ff9dcd426d14fdbafb7cdf5d9020d9a
11 N77b93ea2dce84e6a849644d3c73b3fd4
12 N7c7f39c00a5b4a36beb8d2b9fb953cf4
13 N85b5c954d1d945d692f5b6d5c2b1e50a
14 N99b630d3f9f24d0c9f3ef7437d3bb0d1
15 Na09b2b28d36841d89ce46972b8d5c27f
16 Nb220c3bbb811461e9f2ec0c716b0e694
17 Nb612989abaed4c9f9b1e1bd77264aa82
18 Nc7adcccc86f24c589d2e4577b8a6bc2d
19 Nc897721801a24cba98fbe00fe73551f6
20 Ncd3349e892ad4b94ae1b6a5b9fe9a209
21 Nd3b1025a4e9c4ea0ae556af37e7dca2e
22 Nd496b12078b44df2abaa67c55683522d
23 Nec8c6f9dc387441ba1e9f76eb0ac3721
24 anzsrc-for:06
25 anzsrc-for:0601
26 schema:author Ndadfdd4975214fb390ac0bd41b2b24c1
27 schema:citation sg:pub.10.1007/bf00656997
28 sg:pub.10.1038/227680a0
29 sg:pub.10.1038/346362a0
30 sg:pub.10.1038/346366a0
31 sg:pub.10.1038/352628a0
32 sg:pub.10.1038/354526a0
33 sg:pub.10.1038/358761a0
34 sg:pub.10.1038/ng0892-321
35 https://app.dimensions.ai/details/publication/pub.1075965441
36 https://app.dimensions.ai/details/publication/pub.1075967631
37 https://app.dimensions.ai/details/publication/pub.1078294328
38 https://doi.org/10.1016/0003-2697(77)90043-4
39 https://doi.org/10.1016/0092-8674(90)90148-8
40 https://doi.org/10.1016/0092-8674(91)90072-7
41 https://doi.org/10.1016/0092-8674(91)90498-n
42 https://doi.org/10.1016/0092-8674(92)90155-6
43 https://doi.org/10.1016/0896-6273(92)90196-k
44 https://doi.org/10.1016/s0006-3495(90)82429-2
45 https://doi.org/10.1073/pnas.87.21.8447
46 https://doi.org/10.1083/jcb.118.3.551
47 https://doi.org/10.1126/science.1722350
48 https://doi.org/10.1126/science.2475911
49 https://doi.org/10.1126/science.2570460
50 https://doi.org/10.1128/mcb.11.8.3886
51 https://doi.org/10.1152/ajpcell.1992.262.1.c251
52 schema:datePublished 1993-04
53 schema:datePublishedReg 1993-04-01
54 schema:description The cystic fibrosis transmembrane conductance regulator (CFTR) is a phosphorylation-regulated Cl- channel. In most mammalian cells, the functional consequences of the most common CF mutation, delta F508-CFTR, cannot be assessed as the mutant protein undergoes biosynthetic arrest. However, function can be studied in the baculovirus-insect cell expression system where delta F508-CFTR does not appear to undergo such arrest. Our results show that phosphorylation-regulated Cl- channel activity of delta F508-CFTR is similar to that of wild-type CFTR. This observation was confirmed in comparative studies of purified delta F508-CFTR and CFTR reconstituted in planar lipid bilayers. Therefore, we suggest that this common mutation does not result in a significant alteration in CFTR function.
55 schema:genre research_article
56 schema:inLanguage en
57 schema:isAccessibleForFree false
58 schema:isPartOf N57f3bb748a0a470abf2fb5a882eb4524
59 Na90e4e741add4c2582a3535bba40da27
60 sg:journal.1103138
61 schema:name The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR
62 schema:pagination 311-316
63 schema:productId N0f029b3b330b4d6aa849ab5e49cc5210
64 N1066d81ae92c497fb16d75f13fb8cc9f
65 N2375d7a74211407e8f337f7b68302083
66 N63b5be43d4434c59aa4b8d8d12fe2594
67 Nc80f4645230f48cf8c8f6790dd86aa8f
68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026638555
69 https://doi.org/10.1038/ng0493-311
70 schema:sdDatePublished 2019-04-10T17:20
71 schema:sdLicense https://scigraph.springernature.com/explorer/license/
72 schema:sdPublisher Neaba17b536c04926a22dd618a90291e5
73 schema:url http://www.nature.com/articles/ng0493-311
74 sgo:license sg:explorer/license/
75 sgo:sdDataset articles
76 rdf:type schema:ScholarlyArticle
77 N017fbc9649b143e8ba893a78e3b0dd06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Protein Folding
79 rdf:type schema:DefinedTerm
80 N0f029b3b330b4d6aa849ab5e49cc5210 schema:name doi
81 schema:value 10.1038/ng0493-311
82 rdf:type schema:PropertyValue
83 N1066d81ae92c497fb16d75f13fb8cc9f schema:name nlm_unique_id
84 schema:value 9216904
85 rdf:type schema:PropertyValue
86 N1bdbaa21687a4b27bbd68b6011f24f08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Recombinant Proteins
88 rdf:type schema:DefinedTerm
89 N1e3215cc46754729ac048de51de10d8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Cyclic AMP
91 rdf:type schema:DefinedTerm
92 N2375d7a74211407e8f337f7b68302083 schema:name readcube_id
93 schema:value 7ee73b0ebcddff5dca82b02e5da4d9914576e1521340d63a59d383b205f87f21
94 rdf:type schema:PropertyValue
95 N27b5a1c8f7e44066aeeade190ba6d946 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name CHO Cells
97 rdf:type schema:DefinedTerm
98 N2f14d3ca70014fceaff684c810f1d822 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Sequence Deletion
100 rdf:type schema:DefinedTerm
101 N3c335ade93e3451486daed6e00b4b8b6 rdf:first sg:person.0761067124.12
102 rdf:rest Ne8c8932f57554af9a2f40c3e0de38531
103 N4b15c038ca194f529f07d1ceadca3b01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Transfection
105 rdf:type schema:DefinedTerm
106 N4b3332f760644f2993fc8741d21e327f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cystic Fibrosis
108 rdf:type schema:DefinedTerm
109 N57f3bb748a0a470abf2fb5a882eb4524 schema:issueNumber 4
110 rdf:type schema:PublicationIssue
111 N5bd49fdcc87a4390a89b5404f62b442a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Phosphorylation
113 rdf:type schema:DefinedTerm
114 N5e620e5d95c04cb28af10a06c646fb30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Phenylalanine
116 rdf:type schema:DefinedTerm
117 N63b5be43d4434c59aa4b8d8d12fe2594 schema:name pubmed_id
118 schema:value 7526932
119 rdf:type schema:PropertyValue
120 N6ff9dcd426d14fdbafb7cdf5d9020d9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 N77b93ea2dce84e6a849644d3c73b3fd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Amino Acid Sequence
125 rdf:type schema:DefinedTerm
126 N7c7f39c00a5b4a36beb8d2b9fb953cf4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Membrane Potentials
128 rdf:type schema:DefinedTerm
129 N85b5c954d1d945d692f5b6d5c2b1e50a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Kinetics
131 rdf:type schema:DefinedTerm
132 N99b630d3f9f24d0c9f3ef7437d3bb0d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Molecular Sequence Data
134 rdf:type schema:DefinedTerm
135 Na09b2b28d36841d89ce46972b8d5c27f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Base Sequence
137 rdf:type schema:DefinedTerm
138 Na90e4e741add4c2582a3535bba40da27 schema:volumeNumber 3
139 rdf:type schema:PublicationVolume
140 Nb220c3bbb811461e9f2ec0c716b0e694 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Lipid Bilayers
142 rdf:type schema:DefinedTerm
143 Nb612989abaed4c9f9b1e1bd77264aa82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Cell Line
145 rdf:type schema:DefinedTerm
146 Nc7adcccc86f24c589d2e4577b8a6bc2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Animals
148 rdf:type schema:DefinedTerm
149 Nc80f4645230f48cf8c8f6790dd86aa8f schema:name dimensions_id
150 schema:value pub.1026638555
151 rdf:type schema:PropertyValue
152 Nc897721801a24cba98fbe00fe73551f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cricetinae
154 rdf:type schema:DefinedTerm
155 Ncd3349e892ad4b94ae1b6a5b9fe9a209 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Spodoptera
157 rdf:type schema:DefinedTerm
158 Nd3b1025a4e9c4ea0ae556af37e7dca2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Chloride Channels
160 rdf:type schema:DefinedTerm
161 Nd496b12078b44df2abaa67c55683522d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Cystic Fibrosis Transmembrane Conductance Regulator
163 rdf:type schema:DefinedTerm
164 Ndadfdd4975214fb390ac0bd41b2b24c1 rdf:first sg:person.01175351322.43
165 rdf:rest Nf61c51217d524ea08d9619dce1a65d52
166 Ndb2d86cf786d4d99aed020b3e2e6ab3c rdf:first sg:person.01355172356.46
167 rdf:rest Ne83438ee817c420f8e5672ca111e5d1c
168 Ndba73121c7ed4821afd206df635b2a00 rdf:first sg:person.01310536143.87
169 rdf:rest Ndb2d86cf786d4d99aed020b3e2e6ab3c
170 Ne83438ee817c420f8e5672ca111e5d1c rdf:first sg:person.01251134606.39
171 rdf:rest rdf:nil
172 Ne8c8932f57554af9a2f40c3e0de38531 rdf:first sg:person.016360211272.02
173 rdf:rest Ndba73121c7ed4821afd206df635b2a00
174 Neaba17b536c04926a22dd618a90291e5 schema:name Springer Nature - SN SciGraph project
175 rdf:type schema:Organization
176 Nec8c6f9dc387441ba1e9f76eb0ac3721 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Membrane Proteins
178 rdf:type schema:DefinedTerm
179 Nf61c51217d524ea08d9619dce1a65d52 rdf:first sg:person.01243014415.40
180 rdf:rest N3c335ade93e3451486daed6e00b4b8b6
181 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biological Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
185 schema:name Biochemistry and Cell Biology
186 rdf:type schema:DefinedTerm
187 sg:journal.1103138 schema:issn 1061-4036
188 1546-1718
189 schema:name Nature Genetics
190 rdf:type schema:Periodical
191 sg:person.01175351322.43 schema:affiliation https://www.grid.ac/institutes/grid.42327.30
192 schema:familyName Li
193 schema:givenName C
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175351322.43
195 rdf:type schema:Person
196 sg:person.01243014415.40 schema:familyName Ramjeesingh
197 schema:givenName M
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243014415.40
199 rdf:type schema:Person
200 sg:person.01251134606.39 schema:familyName Bear
201 schema:givenName C E
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251134606.39
203 rdf:type schema:Person
204 sg:person.01310536143.87 schema:familyName Chang
205 schema:givenName X
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310536143.87
207 rdf:type schema:Person
208 sg:person.01355172356.46 schema:familyName Rommens
209 schema:givenName J M
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355172356.46
211 rdf:type schema:Person
212 sg:person.016360211272.02 schema:familyName Jensen
213 schema:givenName T
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016360211272.02
215 rdf:type schema:Person
216 sg:person.0761067124.12 schema:familyName Reyes
217 schema:givenName E
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761067124.12
219 rdf:type schema:Person
220 sg:pub.10.1007/bf00656997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014806333
221 https://doi.org/10.1007/bf00656997
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/227680a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419937
224 https://doi.org/10.1038/227680a0
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/346362a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052799411
227 https://doi.org/10.1038/346362a0
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/346366a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005574691
230 https://doi.org/10.1038/346366a0
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/352628a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044633103
233 https://doi.org/10.1038/352628a0
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/354526a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018163170
236 https://doi.org/10.1038/354526a0
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/358761a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009186996
239 https://doi.org/10.1038/358761a0
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/ng0892-321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039691323
242 https://doi.org/10.1038/ng0892-321
243 rdf:type schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1075965441 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1075967631 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1078294328 schema:CreativeWork
247 https://doi.org/10.1016/0003-2697(77)90043-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043533757
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0092-8674(90)90148-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031197376
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0092-8674(91)90072-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040830484
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0092-8674(91)90498-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1001366314
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0092-8674(92)90155-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047418822
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/0896-6273(92)90196-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1035841266
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0006-3495(90)82429-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015738041
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1073/pnas.87.21.8447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018923177
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1083/jcb.118.3.551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052204146
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1126/science.1722350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062503030
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1126/science.2475911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062539396
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1126/science.2570460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062544667
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1128/mcb.11.8.3886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024866989
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1152/ajpcell.1992.262.1.c251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075951053
274 rdf:type schema:CreativeWork
275 https://www.grid.ac/institutes/grid.42327.30 schema:alternateName Hospital for Sick Children
276 schema:name Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada.
277 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...