Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-03

AUTHORS

Darryl Shibata, Miguel Angel Peinado, Yurij lonov, Sergei Malkhosyan, Manuel Perucho

ABSTRACT

Genomic instability at simple repeated sequences (SRS) is a landmark for some sporadic and hereditary cancers of the colon. We have identified several human tumour cell lines with up to 1,000–fold increases in mutation rates for endogenous microsatellite sequences, relative to normal cells or tumour cells without the mutator phenotype and show that they are very early events in tumorigenesis. Our in vivo and in vitro results show that the genomic instability persists after transformation and that microsatellite mutations accumulate as consecutive somatic slippage events of a single or a few repeated units. This mechanism may account for the repeat expansions in triplet hereditary diseases and the same defect in replication fidelity in non–polyposis colon cancer could also contribute to the non–mendelian anticipation in these diseases. More... »

PAGES

273-281

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0394-273

DOI

http://dx.doi.org/10.1038/ng0394-273

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034106513

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8012390


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Satellite", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligodeoxyribonucleotides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repetitive Sequences, Nucleic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Southern California School of Medicine, 90033, Los Angeles, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.42505.36", 
          "name": [
            "Department of Pathology, University of Southern California School of Medicine, 90033, Los Angeles, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shibata", 
        "givenName": "Darryl", 
        "id": "sg:person.01264261302.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264261302.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut de Recerca Oncologica, Hospital Duran i Reynals, Autovia de Castelldefels, Km 2,7 Hospitalet, 08907, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA", 
            "Institut de Recerca Oncologica, Hospital Duran i Reynals, Autovia de Castelldefels, Km 2,7 Hospitalet, 08907, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peinado", 
        "givenName": "Miguel Angel", 
        "id": "sg:person.016614172622.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016614172622.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "lonov", 
        "givenName": "Yurij", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malkhosyan", 
        "givenName": "Sergei", 
        "id": "sg:person.01211331037.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211331037.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA", 
          "id": "http://www.grid.ac/institutes/grid.250671.7", 
          "name": [
            "California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perucho", 
        "givenName": "Manuel", 
        "id": "sg:person.01000314671.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000314671.43"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/327293a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035638144", 
          "https://doi.org/10.1038/327293a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1193-279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039824484", 
          "https://doi.org/10.1038/ng1193-279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/363558a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043263395", 
          "https://doi.org/10.1038/363558a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/327298a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026973030", 
          "https://doi.org/10.1038/327298a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/255197a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053009387", 
          "https://doi.org/10.1038/255197a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/365274a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019075047", 
          "https://doi.org/10.1038/365274a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/365207a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018737693", 
          "https://doi.org/10.1038/365207a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0593-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012344424", 
          "https://doi.org/10.1038/ng0593-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/352544a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044976791", 
          "https://doi.org/10.1038/352544a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02796440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011329548", 
          "https://doi.org/10.1007/bf02796440"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-03", 
    "datePublishedReg": "1994-03-01", 
    "description": "Genomic instability at simple repeated sequences (SRS) is a landmark for some sporadic and hereditary cancers of the colon. We have identified several human tumour cell lines with up to 1,000\u2013fold increases in mutation rates for endogenous microsatellite sequences, relative to normal cells or tumour cells without the mutator phenotype and show that they are very early events in tumorigenesis. Our in vivo and in vitro results show that the genomic instability persists after transformation and that microsatellite mutations accumulate as consecutive somatic slippage events of a single or a few repeated units. This mechanism may account for the repeat expansions in triplet hereditary diseases and the same defect in replication fidelity in non\u2013polyposis colon cancer could also contribute to the non\u2013mendelian anticipation in these diseases.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ng0394-273", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2468141", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2467126", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "genomic instability", 
      "mutator phenotype", 
      "microsatellite sequences", 
      "early somatic event", 
      "mutation rate", 
      "microsatellite mutations", 
      "replication fidelity", 
      "non-polyposis colon cancer", 
      "repeat expansion", 
      "slippage events", 
      "somatic events", 
      "tumor cell lines", 
      "normal cells", 
      "cell lines", 
      "early events", 
      "human tumor cell lines", 
      "sequence", 
      "colorectal tumorigenesis", 
      "tumorigenesis", 
      "hereditary disease", 
      "colon cancer", 
      "cells", 
      "tumor cells", 
      "phenotype", 
      "mutations", 
      "hereditary cancer", 
      "same defect", 
      "vivo", 
      "events", 
      "mechanism", 
      "cancer", 
      "fidelity", 
      "lines", 
      "defects", 
      "disease", 
      "transformation", 
      "expansion", 
      "instability", 
      "increase", 
      "results", 
      "colon", 
      "rate", 
      "units", 
      "landmarks", 
      "anticipation", 
      "endogenous microsatellite sequences", 
      "consecutive somatic slippage events", 
      "somatic slippage events", 
      "triplet hereditary diseases", 
      "non\u2013mendelian anticipation"
    ], 
    "name": "Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation", 
    "pagination": "273-281", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034106513"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng0394-273"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8012390"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng0394-273", 
      "https://app.dimensions.ai/details/publication/pub.1034106513"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_231.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ng0394-273"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng0394-273'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng0394-273'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng0394-273'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng0394-273'


 

This table displays all metadata directly associated to this object as RDF triples.

250 TRIPLES      22 PREDICATES      102 URIs      81 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng0394-273 schema:about N115ec51e4fc04370b1306379742df1c9
2 N3f54ec117cf94b36ab9da3fa6add8a17
3 N76f909b8d1f549cbb2d5d8af92faa30d
4 N820b049e82a747a9a5579ba1a1c49eea
5 N82f33ec3a0dd4683bfd4b609df95ba5a
6 Na90b1da2d6734d469b83c329e1f00036
7 Nb254df8ad28c4481a4ebbce85f3a4b82
8 Nc4d87ac8fa2a45e7abc43383e7d1c387
9 Nc888e313c7d04c04bc1e5b1bb9ecda9e
10 Nd66d489ce4584ab786ef45341dba7e13
11 Ne43fd5905acc472e88d139229ea5844d
12 Ne7ae8f329e9d40699882fb4c4ca27766
13 anzsrc-for:06
14 anzsrc-for:0601
15 anzsrc-for:0604
16 anzsrc-for:11
17 anzsrc-for:1112
18 schema:author N882d4a733ef74ad890693fccc6a35d03
19 schema:citation sg:pub.10.1007/bf02796440
20 sg:pub.10.1038/255197a0
21 sg:pub.10.1038/327293a0
22 sg:pub.10.1038/327298a0
23 sg:pub.10.1038/352544a0
24 sg:pub.10.1038/363558a0
25 sg:pub.10.1038/365207a0
26 sg:pub.10.1038/365274a0
27 sg:pub.10.1038/ng0593-8
28 sg:pub.10.1038/ng1193-279
29 schema:datePublished 1994-03
30 schema:datePublishedReg 1994-03-01
31 schema:description Genomic instability at simple repeated sequences (SRS) is a landmark for some sporadic and hereditary cancers of the colon. We have identified several human tumour cell lines with up to 1,000–fold increases in mutation rates for endogenous microsatellite sequences, relative to normal cells or tumour cells without the mutator phenotype and show that they are very early events in tumorigenesis. Our in vivo and in vitro results show that the genomic instability persists after transformation and that microsatellite mutations accumulate as consecutive somatic slippage events of a single or a few repeated units. This mechanism may account for the repeat expansions in triplet hereditary diseases and the same defect in replication fidelity in non–polyposis colon cancer could also contribute to the non–mendelian anticipation in these diseases.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf N747212fe39bf4268af595bf37178b558
36 Ndd4089bf8d9f409081fbfbce6718bd3f
37 sg:journal.1103138
38 schema:keywords anticipation
39 cancer
40 cell lines
41 cells
42 colon
43 colon cancer
44 colorectal tumorigenesis
45 consecutive somatic slippage events
46 defects
47 disease
48 early events
49 early somatic event
50 endogenous microsatellite sequences
51 events
52 expansion
53 fidelity
54 genomic instability
55 hereditary cancer
56 hereditary disease
57 human tumor cell lines
58 increase
59 instability
60 landmarks
61 lines
62 mechanism
63 microsatellite mutations
64 microsatellite sequences
65 mutation rate
66 mutations
67 mutator phenotype
68 non-polyposis colon cancer
69 non–mendelian anticipation
70 normal cells
71 phenotype
72 rate
73 repeat expansion
74 replication fidelity
75 results
76 same defect
77 sequence
78 slippage events
79 somatic events
80 somatic slippage events
81 transformation
82 triplet hereditary diseases
83 tumor cell lines
84 tumor cells
85 tumorigenesis
86 units
87 vivo
88 schema:name Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation
89 schema:pagination 273-281
90 schema:productId N0c4d04cc3e6949858d0eba1b83088e8a
91 N8f551369d2b647ac90ea31f0c76a3f7e
92 N920b7bf240af47ebb04aac09b80d1141
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034106513
94 https://doi.org/10.1038/ng0394-273
95 schema:sdDatePublished 2021-12-01T19:07
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher Nc0fe0eae2d9f4f31a0244ba1d18fec9e
98 schema:url https://doi.org/10.1038/ng0394-273
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N0c4d04cc3e6949858d0eba1b83088e8a schema:name pubmed_id
103 schema:value 8012390
104 rdf:type schema:PropertyValue
105 N115ec51e4fc04370b1306379742df1c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Colorectal Neoplasms
107 rdf:type schema:DefinedTerm
108 N2176da0108584c84ab9be7353e0ca197 rdf:first sg:person.016614172622.31
109 rdf:rest Na8a61755f3844b17ad5cb35e2e748c0a
110 N3f54ec117cf94b36ab9da3fa6add8a17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Oligodeoxyribonucleotides
112 rdf:type schema:DefinedTerm
113 N4306f3c2d40f4954b9d9a59f36578d69 rdf:first sg:person.01211331037.55
114 rdf:rest Nbfe09fdb493b4c2182d9e54ffb4cfd23
115 N747212fe39bf4268af595bf37178b558 schema:volumeNumber 6
116 rdf:type schema:PublicationVolume
117 N76f909b8d1f549cbb2d5d8af92faa30d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Phenotype
119 rdf:type schema:DefinedTerm
120 N820b049e82a747a9a5579ba1a1c49eea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 N82f33ec3a0dd4683bfd4b609df95ba5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name DNA, Satellite
125 rdf:type schema:DefinedTerm
126 N882d4a733ef74ad890693fccc6a35d03 rdf:first sg:person.01264261302.03
127 rdf:rest N2176da0108584c84ab9be7353e0ca197
128 N8a4d52ac0b9649c2b19cb3ee63e5555f schema:affiliation grid-institutes:grid.250671.7
129 schema:familyName lonov
130 schema:givenName Yurij
131 rdf:type schema:Person
132 N8f551369d2b647ac90ea31f0c76a3f7e schema:name doi
133 schema:value 10.1038/ng0394-273
134 rdf:type schema:PropertyValue
135 N920b7bf240af47ebb04aac09b80d1141 schema:name dimensions_id
136 schema:value pub.1034106513
137 rdf:type schema:PropertyValue
138 Na8a61755f3844b17ad5cb35e2e748c0a rdf:first N8a4d52ac0b9649c2b19cb3ee63e5555f
139 rdf:rest N4306f3c2d40f4954b9d9a59f36578d69
140 Na90b1da2d6734d469b83c329e1f00036 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Cell Transformation, Neoplastic
142 rdf:type schema:DefinedTerm
143 Nb254df8ad28c4481a4ebbce85f3a4b82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name DNA, Neoplasm
145 rdf:type schema:DefinedTerm
146 Nbfe09fdb493b4c2182d9e54ffb4cfd23 rdf:first sg:person.01000314671.43
147 rdf:rest rdf:nil
148 Nc0fe0eae2d9f4f31a0244ba1d18fec9e schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 Nc4d87ac8fa2a45e7abc43383e7d1c387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Repetitive Sequences, Nucleic Acid
152 rdf:type schema:DefinedTerm
153 Nc888e313c7d04c04bc1e5b1bb9ecda9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Male
155 rdf:type schema:DefinedTerm
156 Nd66d489ce4584ab786ef45341dba7e13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Female
158 rdf:type schema:DefinedTerm
159 Ndd4089bf8d9f409081fbfbce6718bd3f schema:issueNumber 3
160 rdf:type schema:PublicationIssue
161 Ne43fd5905acc472e88d139229ea5844d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Tumor Cells, Cultured
163 rdf:type schema:DefinedTerm
164 Ne7ae8f329e9d40699882fb4c4ca27766 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Mutation
166 rdf:type schema:DefinedTerm
167 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
168 schema:name Biological Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
171 schema:name Biochemistry and Cell Biology
172 rdf:type schema:DefinedTerm
173 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
174 schema:name Genetics
175 rdf:type schema:DefinedTerm
176 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
177 schema:name Medical and Health Sciences
178 rdf:type schema:DefinedTerm
179 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
180 schema:name Oncology and Carcinogenesis
181 rdf:type schema:DefinedTerm
182 sg:grant.2467126 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0394-273
183 rdf:type schema:MonetaryGrant
184 sg:grant.2468141 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0394-273
185 rdf:type schema:MonetaryGrant
186 sg:journal.1103138 schema:issn 1061-4036
187 1546-1718
188 schema:name Nature Genetics
189 schema:publisher Springer Nature
190 rdf:type schema:Periodical
191 sg:person.01000314671.43 schema:affiliation grid-institutes:grid.250671.7
192 schema:familyName Perucho
193 schema:givenName Manuel
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000314671.43
195 rdf:type schema:Person
196 sg:person.01211331037.55 schema:affiliation grid-institutes:grid.250671.7
197 schema:familyName Malkhosyan
198 schema:givenName Sergei
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211331037.55
200 rdf:type schema:Person
201 sg:person.01264261302.03 schema:affiliation grid-institutes:grid.42505.36
202 schema:familyName Shibata
203 schema:givenName Darryl
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264261302.03
205 rdf:type schema:Person
206 sg:person.016614172622.31 schema:affiliation grid-institutes:None
207 schema:familyName Peinado
208 schema:givenName Miguel Angel
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016614172622.31
210 rdf:type schema:Person
211 sg:pub.10.1007/bf02796440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011329548
212 https://doi.org/10.1007/bf02796440
213 rdf:type schema:CreativeWork
214 sg:pub.10.1038/255197a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053009387
215 https://doi.org/10.1038/255197a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/327293a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035638144
218 https://doi.org/10.1038/327293a0
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/327298a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026973030
221 https://doi.org/10.1038/327298a0
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/352544a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044976791
224 https://doi.org/10.1038/352544a0
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/363558a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043263395
227 https://doi.org/10.1038/363558a0
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/365207a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018737693
230 https://doi.org/10.1038/365207a0
231 rdf:type schema:CreativeWork
232 sg:pub.10.1038/365274a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019075047
233 https://doi.org/10.1038/365274a0
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/ng0593-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012344424
236 https://doi.org/10.1038/ng0593-8
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/ng1193-279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039824484
239 https://doi.org/10.1038/ng1193-279
240 rdf:type schema:CreativeWork
241 grid-institutes:None schema:alternateName Institut de Recerca Oncologica, Hospital Duran i Reynals, Autovia de Castelldefels, Km 2,7 Hospitalet, 08907, Barcelona, Spain
242 schema:name California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA
243 Institut de Recerca Oncologica, Hospital Duran i Reynals, Autovia de Castelldefels, Km 2,7 Hospitalet, 08907, Barcelona, Spain
244 rdf:type schema:Organization
245 grid-institutes:grid.250671.7 schema:alternateName California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA
246 schema:name California Institute of Biological Research, 11099 North Torrey Pines Road, 92037, La Jolla, California, USA
247 rdf:type schema:Organization
248 grid-institutes:grid.42505.36 schema:alternateName Department of Pathology, University of Southern California School of Medicine, 90033, Los Angeles, California, USA
249 schema:name Department of Pathology, University of Southern California School of Medicine, 90033, Los Angeles, California, USA
250 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...