Identification of protein coding regions by database similarity search View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-03

AUTHORS

W Gish, D J States

ABSTRACT

Sequence similarity between a translated nucleotide sequence and a known biological protein can provide strong evidence for the presence of a homologous coding region, even between distantly related genes. The computer program BLASTX performed conceptual translation of a nucleotide query sequence followed by a protein database search in one programmatic step. We characterized the sensitivity of BLASTX recognition to the presence of substitution, insertion and deletion errors in the query sequence and to sequence divergence. Reading frames were reliably identified in the presence of 1% query errors, a rate that is typical for primary sequence data. BLASTX is appropriate for use in moderate and large scale sequencing projects at the earliest opportunity, when the data are most prone to containing errors. More... »

PAGES

266-272

Journal

TITLE

Nature Genetics

ISSUE

3

VOLUME

3

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng0393-266

    DOI

    http://dx.doi.org/10.1038/ng0393-266

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040734595

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8485583


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng0393-266'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng0393-266'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng0393-266'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng0393-266'


     

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