Chromosomal localization of long trinucleotide repeats in the human genome by fluorescence in situ hybridization View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1996-02

AUTHORS

T Haaf, G Sirugo, K K Kidd, D C Ward

ABSTRACT

Trinucleotide microsatellites are widespread in the human and other mammalian genomes. Expansions of unstable trinucleotide repeats have been associated so far with a number of different genetic diseases including fragile X, myotonic dystrophy (DM) and Huntington disease. While ten possible trinucleotides can occur at the DNA level, only CTG and CCG repeats are involved in the disorders described so far. However, the repeat expansion detection (RED) technique has identified additional large repeats of ATG, CCT, CTT, and TGG of potentially pathological significance in the human genome. We now show that conclusive information about the chromosomal localization of long trinucleotide repeats can be achieved in a relatively short time using fluorescence in situ hybridization (FISH) with biotin-labelled trinucleotide polymers. Large CTG expansions (> 1 kb) in DM and an unstable (CTG)306 repeat in a patient with schizophrenia were detected by eye through the microscope without electronic enhancement. Digital imaging was used to analyse the chromosomal distribution of long CCA and AGG repeats. Our results suggest that long trinucleotide repeats occur in the normal human genome and that the size of individual repeat loci may be polymorphic. More... »

PAGES

183-185

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0296-183

DOI

http://dx.doi.org/10.1038/ng0296-183

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009113013

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8563757


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biotin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosome Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Probes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Image Processing, Computer-Assisted", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Schizophrenia, Paranoid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trinucleotide Repeats", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Molecular Genetics", 
          "id": "https://www.grid.ac/institutes/grid.419538.2", 
          "name": [
            "Max-Planck-Institute of Molecular Genetics, Berlin, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haaf", 
        "givenName": "T", 
        "id": "sg:person.01003513551.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003513551.76"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Sirugo", 
        "givenName": "G", 
        "id": "sg:person.01061751100.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061751100.64"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kidd", 
        "givenName": "K K", 
        "id": "sg:person.01264224741.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264224741.31"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Ward", 
        "givenName": "D C", 
        "id": "sg:person.014342127402.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014342127402.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.92.9.3636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004536583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0693-135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010674395", 
          "https://doi.org/10.1038/ng0693-135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0294-114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018142611", 
          "https://doi.org/10.1038/ng0294-114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1194-213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027227550", 
          "https://doi.org/10.1038/ng1194-213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1994.1232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035893293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0694-124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045183743", 
          "https://doi.org/10.1038/ng0694-124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0694-124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045183743", 
          "https://doi.org/10.1038/ng0694-124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.950160411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049599206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/1.7.535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059643960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077097194", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-02", 
    "datePublishedReg": "1996-02-01", 
    "description": "Trinucleotide microsatellites are widespread in the human and other mammalian genomes. Expansions of unstable trinucleotide repeats have been associated so far with a number of different genetic diseases including fragile X, myotonic dystrophy (DM) and Huntington disease. While ten possible trinucleotides can occur at the DNA level, only CTG and CCG repeats are involved in the disorders described so far. However, the repeat expansion detection (RED) technique has identified additional large repeats of ATG, CCT, CTT, and TGG of potentially pathological significance in the human genome. We now show that conclusive information about the chromosomal localization of long trinucleotide repeats can be achieved in a relatively short time using fluorescence in situ hybridization (FISH) with biotin-labelled trinucleotide polymers. Large CTG expansions (> 1 kb) in DM and an unstable (CTG)306 repeat in a patient with schizophrenia were detected by eye through the microscope without electronic enhancement. Digital imaging was used to analyse the chromosomal distribution of long CCA and AGG repeats. Our results suggest that long trinucleotide repeats occur in the normal human genome and that the size of individual repeat loci may be polymorphic.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng0296-183", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2547974", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2635947", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2440866", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2439357", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2546292", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Chromosomal localization of long trinucleotide repeats in the human genome by fluorescence in situ hybridization", 
    "pagination": "183-185", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2b6a77246353a520ade7af32e6308b66614c991ef52dfe136227bc556b5d33a5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8563757"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng0296-183"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009113013"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng0296-183", 
      "https://app.dimensions.ai/details/publication/pub.1009113013"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ng/journal/v12/n2/full/ng0296-183.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng0296-183'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng0296-183'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng0296-183'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng0296-183'


 

This table displays all metadata directly associated to this object as RDF triples.

171 TRIPLES      21 PREDICATES      49 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng0296-183 schema:about N1a52e6f4324a48f19855788a8fea3aa8
2 N22fd99d5e0de4320bb6be1b43a51ae06
3 N47e10b77ba794948b61f9941a127cd9f
4 N6266429979244558a4d54738584ea810
5 N76b56649727f4ef7bf522942c252e49f
6 N7d645308aca84b89ae6aaadf5e7c3340
7 N8c890b28fddf43c29ded72716cfeeea0
8 Nb2d782566d26497393900b89d9438687
9 Nb4a889649c63446aa928385ed01bb983
10 Nd1e21780d8a24bcd8aed4df647c0742b
11 Ne3704cde2c3a4837a20577287ca1161a
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author Ncd0cf1f6c031463d8b57f131fe08ef71
15 schema:citation sg:pub.10.1038/ng0294-114
16 sg:pub.10.1038/ng0693-135
17 sg:pub.10.1038/ng0694-124
18 sg:pub.10.1038/ng1194-213
19 https://app.dimensions.ai/details/publication/pub.1077097194
20 https://doi.org/10.1002/bies.950160411
21 https://doi.org/10.1006/geno.1994.1232
22 https://doi.org/10.1073/pnas.92.9.3636
23 https://doi.org/10.1093/hmg/1.7.535
24 schema:datePublished 1996-02
25 schema:datePublishedReg 1996-02-01
26 schema:description Trinucleotide microsatellites are widespread in the human and other mammalian genomes. Expansions of unstable trinucleotide repeats have been associated so far with a number of different genetic diseases including fragile X, myotonic dystrophy (DM) and Huntington disease. While ten possible trinucleotides can occur at the DNA level, only CTG and CCG repeats are involved in the disorders described so far. However, the repeat expansion detection (RED) technique has identified additional large repeats of ATG, CCT, CTT, and TGG of potentially pathological significance in the human genome. We now show that conclusive information about the chromosomal localization of long trinucleotide repeats can be achieved in a relatively short time using fluorescence in situ hybridization (FISH) with biotin-labelled trinucleotide polymers. Large CTG expansions (> 1 kb) in DM and an unstable (CTG)306 repeat in a patient with schizophrenia were detected by eye through the microscope without electronic enhancement. Digital imaging was used to analyse the chromosomal distribution of long CCA and AGG repeats. Our results suggest that long trinucleotide repeats occur in the normal human genome and that the size of individual repeat loci may be polymorphic.
27 schema:genre research_article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf N66f450170f5142b9a7fd94ab0b9bdc34
31 N816057f51b6741c2ab4a29b69a679737
32 sg:journal.1103138
33 schema:name Chromosomal localization of long trinucleotide repeats in the human genome by fluorescence in situ hybridization
34 schema:pagination 183-185
35 schema:productId N6a2447e74f7342b9b9abff8c4e9b7363
36 N9a38c1b4983e406c8199ba96c7f63a74
37 Naffee5afd8634392a596792342d3e261
38 Nb25d8db212654530a2a07f24f06fc0c2
39 Nbe37a43a0a064e1d8a5acab7f2ba1115
40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009113013
41 https://doi.org/10.1038/ng0296-183
42 schema:sdDatePublished 2019-04-10T13:57
43 schema:sdLicense https://scigraph.springernature.com/explorer/license/
44 schema:sdPublisher N7a70ff7a76884249a8701224d2da9bde
45 schema:url http://www.nature.com/ng/journal/v12/n2/full/ng0296-183.html
46 sgo:license sg:explorer/license/
47 sgo:sdDataset articles
48 rdf:type schema:ScholarlyArticle
49 N072b9621b22e4f9bbf4cc62f2b60ebb7 rdf:first sg:person.01264224741.31
50 rdf:rest N7501b99bbf734fb087dea5e93f3f656b
51 N1a52e6f4324a48f19855788a8fea3aa8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
52 schema:name Base Sequence
53 rdf:type schema:DefinedTerm
54 N22fd99d5e0de4320bb6be1b43a51ae06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
55 schema:name DNA Probes
56 rdf:type schema:DefinedTerm
57 N47e10b77ba794948b61f9941a127cd9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
58 schema:name Chromosome Mapping
59 rdf:type schema:DefinedTerm
60 N6266429979244558a4d54738584ea810 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Schizophrenia, Paranoid
62 rdf:type schema:DefinedTerm
63 N66f450170f5142b9a7fd94ab0b9bdc34 schema:volumeNumber 12
64 rdf:type schema:PublicationVolume
65 N690b807e1adf48f48fcf7da77673e0a7 rdf:first sg:person.01061751100.64
66 rdf:rest N072b9621b22e4f9bbf4cc62f2b60ebb7
67 N6a2447e74f7342b9b9abff8c4e9b7363 schema:name doi
68 schema:value 10.1038/ng0296-183
69 rdf:type schema:PropertyValue
70 N7501b99bbf734fb087dea5e93f3f656b rdf:first sg:person.014342127402.60
71 rdf:rest rdf:nil
72 N76b56649727f4ef7bf522942c252e49f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Image Processing, Computer-Assisted
74 rdf:type schema:DefinedTerm
75 N7a70ff7a76884249a8701224d2da9bde schema:name Springer Nature - SN SciGraph project
76 rdf:type schema:Organization
77 N7d645308aca84b89ae6aaadf5e7c3340 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Genome
79 rdf:type schema:DefinedTerm
80 N816057f51b6741c2ab4a29b69a679737 schema:issueNumber 2
81 rdf:type schema:PublicationIssue
82 N8c890b28fddf43c29ded72716cfeeea0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name In Situ Hybridization, Fluorescence
84 rdf:type schema:DefinedTerm
85 N9a38c1b4983e406c8199ba96c7f63a74 schema:name dimensions_id
86 schema:value pub.1009113013
87 rdf:type schema:PropertyValue
88 Naffee5afd8634392a596792342d3e261 schema:name nlm_unique_id
89 schema:value 9216904
90 rdf:type schema:PropertyValue
91 Nb25d8db212654530a2a07f24f06fc0c2 schema:name readcube_id
92 schema:value 2b6a77246353a520ade7af32e6308b66614c991ef52dfe136227bc556b5d33a5
93 rdf:type schema:PropertyValue
94 Nb2d782566d26497393900b89d9438687 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Molecular Sequence Data
96 rdf:type schema:DefinedTerm
97 Nb4a889649c63446aa928385ed01bb983 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 Nbe37a43a0a064e1d8a5acab7f2ba1115 schema:name pubmed_id
101 schema:value 8563757
102 rdf:type schema:PropertyValue
103 Ncd0cf1f6c031463d8b57f131fe08ef71 rdf:first sg:person.01003513551.76
104 rdf:rest N690b807e1adf48f48fcf7da77673e0a7
105 Nd1e21780d8a24bcd8aed4df647c0742b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Biotin
107 rdf:type schema:DefinedTerm
108 Ne3704cde2c3a4837a20577287ca1161a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Trinucleotide Repeats
110 rdf:type schema:DefinedTerm
111 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
112 schema:name Biological Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
115 schema:name Genetics
116 rdf:type schema:DefinedTerm
117 sg:grant.2439357 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0296-183
118 rdf:type schema:MonetaryGrant
119 sg:grant.2440866 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0296-183
120 rdf:type schema:MonetaryGrant
121 sg:grant.2546292 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0296-183
122 rdf:type schema:MonetaryGrant
123 sg:grant.2547974 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0296-183
124 rdf:type schema:MonetaryGrant
125 sg:grant.2635947 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0296-183
126 rdf:type schema:MonetaryGrant
127 sg:journal.1103138 schema:issn 1061-4036
128 1546-1718
129 schema:name Nature Genetics
130 rdf:type schema:Periodical
131 sg:person.01003513551.76 schema:affiliation https://www.grid.ac/institutes/grid.419538.2
132 schema:familyName Haaf
133 schema:givenName T
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003513551.76
135 rdf:type schema:Person
136 sg:person.01061751100.64 schema:familyName Sirugo
137 schema:givenName G
138 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061751100.64
139 rdf:type schema:Person
140 sg:person.01264224741.31 schema:familyName Kidd
141 schema:givenName K K
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264224741.31
143 rdf:type schema:Person
144 sg:person.014342127402.60 schema:familyName Ward
145 schema:givenName D C
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014342127402.60
147 rdf:type schema:Person
148 sg:pub.10.1038/ng0294-114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018142611
149 https://doi.org/10.1038/ng0294-114
150 rdf:type schema:CreativeWork
151 sg:pub.10.1038/ng0693-135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010674395
152 https://doi.org/10.1038/ng0693-135
153 rdf:type schema:CreativeWork
154 sg:pub.10.1038/ng0694-124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045183743
155 https://doi.org/10.1038/ng0694-124
156 rdf:type schema:CreativeWork
157 sg:pub.10.1038/ng1194-213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027227550
158 https://doi.org/10.1038/ng1194-213
159 rdf:type schema:CreativeWork
160 https://app.dimensions.ai/details/publication/pub.1077097194 schema:CreativeWork
161 https://doi.org/10.1002/bies.950160411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049599206
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1006/geno.1994.1232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035893293
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1073/pnas.92.9.3636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004536583
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1093/hmg/1.7.535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059643960
168 rdf:type schema:CreativeWork
169 https://www.grid.ac/institutes/grid.419538.2 schema:alternateName Max Planck Institute for Molecular Genetics
170 schema:name Max-Planck-Institute of Molecular Genetics, Berlin, Germany.
171 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...