The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-02

AUTHORS

C N Tennyson, H J Klamut, R G Worton

ABSTRACT

The largest known gene is the human dystrophin gene, which has 79 exons spanning at least 2,300 kilobases (kb). Transcript accumulation was monitored from four regions of the gene following induction of expression in muscle cell cultures. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) results indicate that approximately 12 h are required for transcription of 1,770 kb (at an average elongation rate of 2.4 kb min-1), extrapolating to a transcription time of 16 h for the complete gene. Accumulation profiles for spliced and total transcript demonstrated that transcripts are spliced at the 5' end before transcription is complete providing strong evidence for cotranscriptional splicing. The rate of transcript accumulation was reduced at the 3' end of the gene relative to the 5' end, perhaps due to premature termination of transcription complexes. More... »

PAGES

184-190

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0295-184

DOI

http://dx.doi.org/10.1038/ng0295-184

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049782732

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7719347


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