Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-02

AUTHORS

Gabriele Dodt, Nancy Braverman, Candice Wong, Ann Moser, Hugo W. Moser, Paul Watkins, David Valle, Stephen J. Gould

ABSTRACT

The peroxisome biogenesis disorders (PBDs) are lethal recessive diseases caused by defects in peroxisome assembly. We have isolated PXR1, a human homologue of the yeast P. pastoris PAS8 (peroxisome assembly) gene. PXR1, like PAS8, encodes a receptor for proteins with the type–1 peroxisomal targeting signal (PTS1). Mutations in PXR1 define complementation group 2 of PBDs and expression of PXR1 rescues the PTS1 import defect of fibroblasts from these patients. Based on the observation that PXR1 exists both in the cytosol and in association with peroxisomes, we propose that PXR1 protein recognizes PTS1 –containing proteins in the cytosol and directs them to the peroxisome. More... »

PAGES

115-125

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng0295-115

DOI

http://dx.doi.org/10.1038/ng0295-115

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028344814

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7719337


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytosol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Complementation Test", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolic Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microbodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peroxisome-Targeting Signal 1 Receptor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cell Surface", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Cytoplasmic and Nuclear", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Nucleic Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Yeasts", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Departments of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Kennedy Krieger Research Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
            "Departments of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dodt", 
        "givenName": "Gabriele", 
        "id": "sg:person.0724151645.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724151645.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Pediatrics, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Departments of Pediatrics, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Braverman", 
        "givenName": "Nancy", 
        "id": "sg:person.01237351716.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237351716.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Kennedy Krieger Research Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
            "Departments of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wong", 
        "givenName": "Candice", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Kennedy Krieger Research Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Kennedy Krieger Research Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moser", 
        "givenName": "Ann", 
        "id": "sg:person.014175251677.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014175251677.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Neurology, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Kennedy Krieger Research Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
            "Departments of Neurology, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moser", 
        "givenName": "Hugo W.", 
        "id": "sg:person.01104212170.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104212170.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Neurology, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Departments of Neurology, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watkins", 
        "givenName": "Paul", 
        "id": "sg:person.0637700713.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637700713.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Departments of Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Departments of Pediatrics, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
            "Departments of Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valle", 
        "givenName": "David", 
        "id": "sg:person.01127313751.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127313751.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "The Kennedy Krieger Research Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
            "Departments of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA", 
            "Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gould", 
        "givenName": "Stephen J.", 
        "id": "sg:person.014377146622.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014377146622.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00279370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007322002", 
          "https://doi.org/10.1007/bf00279370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00309932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025550052", 
          "https://doi.org/10.1007/bf00309932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0893-373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039932477", 
          "https://doi.org/10.1038/ng0893-373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0492-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049088366", 
          "https://doi.org/10.1038/ng0492-16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-198907000-00019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006154044", 
          "https://doi.org/10.1203/00006450-198907000-00019"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-02", 
    "datePublishedReg": "1995-02-01", 
    "description": "The peroxisome biogenesis disorders (PBDs) are lethal recessive diseases caused by defects in peroxisome assembly. We have isolated PXR1, a human homologue of the yeast P. pastoris PAS8 (peroxisome assembly) gene. PXR1, like PAS8, encodes a receptor for proteins with the type\u20131 peroxisomal targeting signal (PTS1). Mutations in PXR1 define complementation group 2 of PBDs and expression of PXR1 rescues the PTS1 import defect of fibroblasts from these patients. Based on the observation that PXR1 exists both in the cytosol and in association with peroxisomes, we propose that PXR1 protein recognizes PTS1 \u2013containing proteins in the cytosol and directs them to the peroxisome.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/ng0295-115", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2494822", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683766", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2436472", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "peroxisome biogenesis disorders", 
      "complementation group 2", 
      "biogenesis disorders", 
      "PTS1-containing proteins", 
      "import defect", 
      "peroxisome assembly", 
      "human homologue", 
      "PXR1", 
      "lethal recessive disease", 
      "receptor gene", 
      "protein", 
      "genes", 
      "cytosol", 
      "peroxisomes", 
      "mutations", 
      "recessive disease", 
      "PAS8", 
      "homologues", 
      "fibroblasts", 
      "expression", 
      "assembly", 
      "type 1", 
      "receptors", 
      "defects", 
      "signals", 
      "disorders", 
      "disease", 
      "association", 
      "observations", 
      "group 2", 
      "patients"
    ], 
    "name": "Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders", 
    "pagination": "115-125", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028344814"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng0295-115"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7719337"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng0295-115", 
      "https://app.dimensions.ai/details/publication/pub.1028344814"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_292.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/ng0295-115"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng0295-115'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng0295-115'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng0295-115'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng0295-115'


 

This table displays all metadata directly associated to this object as RDF triples.

248 TRIPLES      21 PREDICATES      80 URIs      67 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng0295-115 schema:about N0ae5521aebbf4bf2b8fc0673a8a65ad0
2 N0b9463183e2d4569a6fa531e713fbe6c
3 N0dd3199685004dfb9631ddda09bb66dd
4 N2989891f80ac4134ab48ce03d9429100
5 N4f3691b31c7f40ccbea419c469bf60af
6 N5ff241139f5646b58fb77a1b9f96bf31
7 N79f534e387b9458d90bb8bb780aff0b4
8 N867d868821f043149c19271c681d3dc3
9 N9a4cfcfcb600498e97c6f9fc18aef98d
10 N9f53dbc5f13c467eb04c608de4aa9394
11 Na7aed4e14f514ad79f2ac6ea1906633e
12 Nba4eaad70dad4191a4e021be5e411810
13 Nbd1d34c8fe0a4bc2beed6fe6186a5013
14 Ncb139bbb9169448c96ef606590ca3415
15 Nd7a10e8bde464a55867d64b7571f93eb
16 Ne449bdffa76443f8a7554f28aa342d7c
17 Nf8c76a90def740f78487a68f26f762d8
18 Nf8e3f65000b344269064473cd49366ae
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author Na19fa04c201944e0b245550e2b288c28
22 schema:citation sg:pub.10.1007/bf00279370
23 sg:pub.10.1007/bf00309932
24 sg:pub.10.1038/ng0492-16
25 sg:pub.10.1038/ng0893-373
26 sg:pub.10.1203/00006450-198907000-00019
27 schema:datePublished 1995-02
28 schema:datePublishedReg 1995-02-01
29 schema:description The peroxisome biogenesis disorders (PBDs) are lethal recessive diseases caused by defects in peroxisome assembly. We have isolated PXR1, a human homologue of the yeast P. pastoris PAS8 (peroxisome assembly) gene. PXR1, like PAS8, encodes a receptor for proteins with the type–1 peroxisomal targeting signal (PTS1). Mutations in PXR1 define complementation group 2 of PBDs and expression of PXR1 rescues the PTS1 import defect of fibroblasts from these patients. Based on the observation that PXR1 exists both in the cytosol and in association with peroxisomes, we propose that PXR1 protein recognizes PTS1 –containing proteins in the cytosol and directs them to the peroxisome.
30 schema:genre article
31 schema:isAccessibleForFree false
32 schema:isPartOf Nca9b219ace1546a7b521beec9e6b54ec
33 Nf4ded13fdd2e417295d0d8eaedd3aa99
34 sg:journal.1103138
35 schema:keywords PAS8
36 PTS1-containing proteins
37 PXR1
38 assembly
39 association
40 biogenesis disorders
41 complementation group 2
42 cytosol
43 defects
44 disease
45 disorders
46 expression
47 fibroblasts
48 genes
49 group 2
50 homologues
51 human homologue
52 import defect
53 lethal recessive disease
54 mutations
55 observations
56 patients
57 peroxisome assembly
58 peroxisome biogenesis disorders
59 peroxisomes
60 protein
61 receptor gene
62 receptors
63 recessive disease
64 signals
65 type 1
66 schema:name Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders
67 schema:pagination 115-125
68 schema:productId N1eef305f0dde495c9866ad9ff1614edb
69 N36926eaba7564d72b9ef8540a76323f0
70 N7aa7a70bc5e84f37a84f1f169489141a
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028344814
72 https://doi.org/10.1038/ng0295-115
73 schema:sdDatePublished 2022-09-02T15:49
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Nc2b880ce17c441acb1e854183dd94af2
76 schema:url https://doi.org/10.1038/ng0295-115
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0725e99c8910485994e9d514f6dcfd94 rdf:first sg:person.014175251677.23
81 rdf:rest N1ea6d83919504432b3756705f6a06750
82 N0ae5521aebbf4bf2b8fc0673a8a65ad0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Molecular Sequence Data
84 rdf:type schema:DefinedTerm
85 N0b9463183e2d4569a6fa531e713fbe6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Amino Acid Sequence
87 rdf:type schema:DefinedTerm
88 N0dd3199685004dfb9631ddda09bb66dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Carrier Proteins
90 rdf:type schema:DefinedTerm
91 N1ea6d83919504432b3756705f6a06750 rdf:first sg:person.01104212170.65
92 rdf:rest Ne33568e5dba34f8cab057b9b83ee9168
93 N1eef305f0dde495c9866ad9ff1614edb schema:name dimensions_id
94 schema:value pub.1028344814
95 rdf:type schema:PropertyValue
96 N247c79fd0419451f9bb07bf0581e66d1 rdf:first N4a6f1ba5ac3f42c382398f27be8455f0
97 rdf:rest N0725e99c8910485994e9d514f6dcfd94
98 N25179c709f7e42e2a9066dc93dcbef22 rdf:first sg:person.01127313751.25
99 rdf:rest N2bd105e8c40d4543b4adce7c6ac2f7ab
100 N2989891f80ac4134ab48ce03d9429100 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Cytosol
102 rdf:type schema:DefinedTerm
103 N2bd105e8c40d4543b4adce7c6ac2f7ab rdf:first sg:person.014377146622.60
104 rdf:rest rdf:nil
105 N36926eaba7564d72b9ef8540a76323f0 schema:name pubmed_id
106 schema:value 7719337
107 rdf:type schema:PropertyValue
108 N4a6f1ba5ac3f42c382398f27be8455f0 schema:affiliation grid-institutes:grid.21107.35
109 schema:familyName Wong
110 schema:givenName Candice
111 rdf:type schema:Person
112 N4f3691b31c7f40ccbea419c469bf60af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Saccharomyces cerevisiae
114 rdf:type schema:DefinedTerm
115 N5ff241139f5646b58fb77a1b9f96bf31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Mutation
117 rdf:type schema:DefinedTerm
118 N79f534e387b9458d90bb8bb780aff0b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Genetic Complementation Test
120 rdf:type schema:DefinedTerm
121 N7aa7a70bc5e84f37a84f1f169489141a schema:name doi
122 schema:value 10.1038/ng0295-115
123 rdf:type schema:PropertyValue
124 N867d868821f043149c19271c681d3dc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Receptors, Cytoplasmic and Nuclear
126 rdf:type schema:DefinedTerm
127 N9741c815316e493a99f4849b6f539de9 rdf:first sg:person.01237351716.55
128 rdf:rest N247c79fd0419451f9bb07bf0581e66d1
129 N9a4cfcfcb600498e97c6f9fc18aef98d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Membrane Proteins
131 rdf:type schema:DefinedTerm
132 N9f53dbc5f13c467eb04c608de4aa9394 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Genes, Fungal
134 rdf:type schema:DefinedTerm
135 Na19fa04c201944e0b245550e2b288c28 rdf:first sg:person.0724151645.08
136 rdf:rest N9741c815316e493a99f4849b6f539de9
137 Na7aed4e14f514ad79f2ac6ea1906633e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Signal Transduction
139 rdf:type schema:DefinedTerm
140 Nba4eaad70dad4191a4e021be5e411810 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Metabolic Diseases
142 rdf:type schema:DefinedTerm
143 Nbd1d34c8fe0a4bc2beed6fe6186a5013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Receptors, Cell Surface
145 rdf:type schema:DefinedTerm
146 Nc2b880ce17c441acb1e854183dd94af2 schema:name Springer Nature - SN SciGraph project
147 rdf:type schema:Organization
148 Nca9b219ace1546a7b521beec9e6b54ec schema:volumeNumber 9
149 rdf:type schema:PublicationVolume
150 Ncb139bbb9169448c96ef606590ca3415 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Humans
152 rdf:type schema:DefinedTerm
153 Nd7a10e8bde464a55867d64b7571f93eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Peroxisome-Targeting Signal 1 Receptor
155 rdf:type schema:DefinedTerm
156 Ne33568e5dba34f8cab057b9b83ee9168 rdf:first sg:person.0637700713.41
157 rdf:rest N25179c709f7e42e2a9066dc93dcbef22
158 Ne449bdffa76443f8a7554f28aa342d7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Microbodies
160 rdf:type schema:DefinedTerm
161 Nf4ded13fdd2e417295d0d8eaedd3aa99 schema:issueNumber 2
162 rdf:type schema:PublicationIssue
163 Nf8c76a90def740f78487a68f26f762d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Yeasts
165 rdf:type schema:DefinedTerm
166 Nf8e3f65000b344269064473cd49366ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Sequence Homology, Nucleic Acid
168 rdf:type schema:DefinedTerm
169 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
170 schema:name Biological Sciences
171 rdf:type schema:DefinedTerm
172 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
173 schema:name Biochemistry and Cell Biology
174 rdf:type schema:DefinedTerm
175 sg:grant.2436472 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0295-115
176 rdf:type schema:MonetaryGrant
177 sg:grant.2494822 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0295-115
178 rdf:type schema:MonetaryGrant
179 sg:grant.2683766 http://pending.schema.org/fundedItem sg:pub.10.1038/ng0295-115
180 rdf:type schema:MonetaryGrant
181 sg:journal.1103138 schema:issn 1061-4036
182 1546-1718
183 schema:name Nature Genetics
184 schema:publisher Springer Nature
185 rdf:type schema:Periodical
186 sg:person.01104212170.65 schema:affiliation grid-institutes:grid.21107.35
187 schema:familyName Moser
188 schema:givenName Hugo W.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104212170.65
190 rdf:type schema:Person
191 sg:person.01127313751.25 schema:affiliation grid-institutes:grid.21107.35
192 schema:familyName Valle
193 schema:givenName David
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127313751.25
195 rdf:type schema:Person
196 sg:person.01237351716.55 schema:affiliation grid-institutes:grid.21107.35
197 schema:familyName Braverman
198 schema:givenName Nancy
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237351716.55
200 rdf:type schema:Person
201 sg:person.014175251677.23 schema:affiliation grid-institutes:grid.21107.35
202 schema:familyName Moser
203 schema:givenName Ann
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014175251677.23
205 rdf:type schema:Person
206 sg:person.014377146622.60 schema:affiliation grid-institutes:grid.21107.35
207 schema:familyName Gould
208 schema:givenName Stephen J.
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014377146622.60
210 rdf:type schema:Person
211 sg:person.0637700713.41 schema:affiliation grid-institutes:grid.21107.35
212 schema:familyName Watkins
213 schema:givenName Paul
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637700713.41
215 rdf:type schema:Person
216 sg:person.0724151645.08 schema:affiliation grid-institutes:grid.21107.35
217 schema:familyName Dodt
218 schema:givenName Gabriele
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724151645.08
220 rdf:type schema:Person
221 sg:pub.10.1007/bf00279370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007322002
222 https://doi.org/10.1007/bf00279370
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/bf00309932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025550052
225 https://doi.org/10.1007/bf00309932
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/ng0492-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049088366
228 https://doi.org/10.1038/ng0492-16
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/ng0893-373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039932477
231 https://doi.org/10.1038/ng0893-373
232 rdf:type schema:CreativeWork
233 sg:pub.10.1203/00006450-198907000-00019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006154044
234 https://doi.org/10.1203/00006450-198907000-00019
235 rdf:type schema:CreativeWork
236 grid-institutes:grid.21107.35 schema:alternateName Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
237 Departments of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
238 Departments of Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
239 Departments of Neurology, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
240 Departments of Pediatrics, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
241 The Kennedy Krieger Research Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
242 schema:name Department of Biological Chemistry, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
243 Departments of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
244 Departments of Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
245 Departments of Neurology, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
246 Departments of Pediatrics, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
247 The Kennedy Krieger Research Institute, The Johns Hopkins University School of Medicine, 21205, Baltimore, Maryland, USA
248 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...