Issues in searching molecular sequence databases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-02

AUTHORS

S F Altschul, M S Boguski, W Gish, J C Wootton

ABSTRACT

Sequence similarity search programs are versatile tools for the molecular biologist, frequently able to identify possible DNA coding regions and to provide clues to gene and protein structure and function. While much attention had been paid to the precise algorithms these programs employ and to their relative speeds, there is a constellation of associated issues that are equally important to realize the full potential of these methods. Here, we consider a number of these issues, including the choice of scoring systems, the statistical significance of alignments, the masking of uninformative or potentially confounding sequence regions, the nature and extent of sequence redundancy in the databases and network access to similarity search services. More... »

PAGES

119-129

References to SciGraph publications

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    2

    VOLUME

    6

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng0294-119

    DOI

    http://dx.doi.org/10.1038/ng0294-119

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043787384

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8162065


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