Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-11

AUTHORS

Manuel A Rivas, Mélissa Beaudoin, Agnes Gardet, Christine Stevens, Yashoda Sharma, Clarence K Zhang, Gabrielle Boucher, Stephan Ripke, David Ellinghaus, Noel Burtt, Tim Fennell, Andrew Kirby, Anna Latiano, Philippe Goyette, Todd Green, Jonas Halfvarson, Talin Haritunians, Joshua M Korn, Finny Kuruvilla, Caroline Lagacé, Benjamin Neale, Ken Sin Lo, Phil Schumm, Leif Törkvist, Institute of Diabetes and Digestive Kidney Diseases Inflammatory Bowel Disease Genetics Consortium, Inflammatory Bowel Disease Genetics Consortium, International Inflammatory Bowel Disease Genetics Consortium, Marla C Dubinsky, Steven R Brant, Mark S Silverberg, Richard H Duerr, David Altshuler, Stacey Gabriel, Guillaume Lettre, Andre Franke, Mauro D'Amato, Dermot P B McGovern, Judy H Cho, John D Rioux, Ramnik J Xavier, Mark J Daly

ABSTRACT

More than 1,000 susceptibility loci have been identified through genome-wide association studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of causal variants underlying these findings have not yet been defined. Here we used pooled next-generation sequencing to study 56 genes from regions associated with Crohn's disease in 350 cases and 350 controls. Through follow-up genotyping of 70 rare and low-frequency protein-altering variants in nine independent case-control series (16,054 Crohn's disease cases, 12,153 ulcerative colitis cases and 17,575 healthy controls), we identified four additional independent risk factors in NOD2, two additional protective variants in IL23R, a highly significant association with a protective splice variant in CARD9 (P < 1 × 10(-16), odds ratio ≈ 0.29) and additional associations with coding variants in IL18RAP, CUL2, C1orf106, PTPN22 and MUC19. We extend the results of successful GWAS by identifying new, rare and probably functional variants that could aid functional experiments and predictive models. More... »

PAGES

1066

References to SciGraph publications

  • 2010-07-01. Network organization of the human autophagy system in NATURE
  • 2009-06. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes in NATURE GENETICS
  • 2010-06. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci in NATURE GENETICS
  • 2001-05. Human genetics: Tackling common disease in NATURE
  • 2008-08. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease in NATURE GENETICS
  • 2010-04. Genome-wide association identifies multiple ulcerative colitis susceptibility loci in NATURE GENETICS
  • 2010-12. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci in NATURE GENETICS
  • 2011-01. Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease in NATURE GENETICS
  • 2009-02. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing in NATURE BIOTECHNOLOGY
  • 2007-05. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis in NATURE GENETICS
  • 2005-06. Paths to understanding the genetic basis of autoimmune disease in NATURE
  • 2010-10. Generation of pathogenic TH17 cells in the absence of TGF-β signalling in NATURE
  • 2001-05. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease in NATURE
  • 2001-09. CARD15 mutations in Blau syndrome in NATURE GENETICS
  • 2010-10. High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency in NATURE GENETICS
  • 2001-05. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease in NATURE
  • 2010-10-28. A map of human genome variation from population-scale sequencing in NATURE
  • 2007-07. Guilt beyond a reasonable doubt in NATURE GENETICS
  • 2002-12. Single nucleotide polymorphisms: Tackling complexity in NATURE
  • 2011-03. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 in NATURE GENETICS
  • 2011-09. The functional spectrum of low-frequency coding variation in GENOME BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.952

    DOI

    http://dx.doi.org/10.1038/ng.952

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043485621

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21983784


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