Ontology type: schema:ScholarlyArticle Open Access: True
2011-12
AUTHORSXinxian Deng, Joseph B Hiatt, Di Kim Nguyen, Sevinc Ercan, David Sturgill, LaDeana W Hillier, Felix Schlesinger, Carrie A Davis, Valerie J Reinke, Thomas R Gingeras, Jay Shendure, Robert H Waterston, Brian Oliver, Jason D Lieb, Christine M Disteche
ABSTRACTMany animal species use a chromosome-based mechanism of sex determination, which has led to the coordinate evolution of dosage-compensation systems. Dosage compensation not only corrects the imbalance in the number of X chromosomes between the sexes but also is hypothesized to correct dosage imbalance within cells that is due to monoallelic X-linked expression and biallelic autosomal expression, by upregulating X-linked genes twofold (termed 'Ohno's hypothesis'). Although this hypothesis is well supported by expression analyses of individual X-linked genes and by microarray-based transcriptome analyses, it was challenged by a recent study using RNA sequencing and proteomics. We obtained new, independent RNA-seq data, measured RNA polymerase distribution and reanalyzed published expression data in mammals, C. elegans and Drosophila. Our analyses, which take into account the skewed gene content of the X chromosome, support the hypothesis of upregulation of expressed X-linked genes to balance expression of the genome. More... »
PAGES1179
http://scigraph.springernature.com/pub.10.1038/ng.948
DOIhttp://dx.doi.org/10.1038/ng.948
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1037441343
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22019781
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Caenorhabditis elegans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Dosage Compensation, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drosophila Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drosophila melanogaster",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Profiling",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression Regulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genes, X-Linked",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Oligonucleotide Array Sequence Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Organ Specificity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ovary",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA Polymerase II",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Testis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transcription, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Up-Regulation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "X Chromosome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Deng",
"givenName": "Xinxian",
"id": "sg:person.01307242542.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307242542.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Hiatt",
"givenName": "Joseph B",
"id": "sg:person.01355355742.29",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355355742.29"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Di Kim Nguyen",
"id": "sg:person.010376761103.13",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010376761103.13"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "New York University",
"id": "https://www.grid.ac/institutes/grid.137628.9",
"name": [
"Department of Biology and Center for Genomics and Systems Biology, New York University, New York, New York, USA."
],
"type": "Organization"
},
"familyName": "Ercan",
"givenName": "Sevinc",
"id": "sg:person.01156757057.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01156757057.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute of Diabetes and Digestive and Kidney Diseases",
"id": "https://www.grid.ac/institutes/grid.419635.c",
"name": [
"Section of Developmental Genomics, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Sturgill",
"givenName": "David",
"id": "sg:person.01343174453.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343174453.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Washington University in St. Louis",
"id": "https://www.grid.ac/institutes/grid.4367.6",
"name": [
"Genome Sequencing Center, Washington University School of Medicine, Saint Louis, Missouri, USA."
],
"type": "Organization"
},
"familyName": "Hillier",
"givenName": "LaDeana W",
"id": "sg:person.01014313442.46",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014313442.46"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cold Spring Harbor Laboratory",
"id": "https://www.grid.ac/institutes/grid.225279.9",
"name": [
"Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA."
],
"type": "Organization"
},
"familyName": "Schlesinger",
"givenName": "Felix",
"id": "sg:person.01062426642.05",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062426642.05"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cold Spring Harbor Laboratory",
"id": "https://www.grid.ac/institutes/grid.225279.9",
"name": [
"Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA."
],
"type": "Organization"
},
"familyName": "Davis",
"givenName": "Carrie A",
"id": "sg:person.01130542042.49",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01130542042.49"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yale University",
"id": "https://www.grid.ac/institutes/grid.47100.32",
"name": [
"Department of Genetics, Yale University, New Haven, Connecticut, USA."
],
"type": "Organization"
},
"familyName": "Reinke",
"givenName": "Valerie J",
"id": "sg:person.01145344072.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145344072.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cold Spring Harbor Laboratory",
"id": "https://www.grid.ac/institutes/grid.225279.9",
"name": [
"Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA."
],
"type": "Organization"
},
"familyName": "Gingeras",
"givenName": "Thomas R",
"id": "sg:person.0673367431.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673367431.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Shendure",
"givenName": "Jay",
"id": "sg:person.01221110417.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221110417.53"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Genome Sciences, University of Washington School of Medicine, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Waterston",
"givenName": "Robert H",
"id": "sg:person.0772724136.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772724136.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute of Diabetes and Digestive and Kidney Diseases",
"id": "https://www.grid.ac/institutes/grid.419635.c",
"name": [
"Section of Developmental Genomics, Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland, USA."
],
"type": "Organization"
},
"familyName": "Oliver",
"givenName": "Brian",
"id": "sg:person.01003467352.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003467352.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of North Carolina at Chapel Hill",
"id": "https://www.grid.ac/institutes/grid.10698.36",
"name": [
"Department of Biology, Carolina Center for the Genome Sciences and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA."
],
"type": "Organization"
},
"familyName": "Lieb",
"givenName": "Jason D",
"id": "sg:person.01070575225.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070575225.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Washington",
"id": "https://www.grid.ac/institutes/grid.34477.33",
"name": [
"Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA.",
"Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA."
],
"type": "Organization"
},
"familyName": "Disteche",
"givenName": "Christine M",
"id": "sg:person.01071102663.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071102663.03"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/cr.2010.64",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000210326",
"https://doi.org/10.1038/cr.2010.64"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.1000320",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000563408"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1098/rspb.1999.0623",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003064942"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.711",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005564718",
"https://doi.org/10.1038/ng.711"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/jbiol30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006105526",
"https://doi.org/10.1186/jbiol30"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1983",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006360808",
"https://doi.org/10.1038/ng1983"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03479",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007477207",
"https://doi.org/10.1038/nature03479"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03479",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007477207",
"https://doi.org/10.1038/nature03479"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.1371",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011651858",
"https://doi.org/10.1038/nmeth.1371"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bioinformatics/btp120",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012425816"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.0050326",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012872303"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tig.2008.05.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014171754"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1242/dev.000018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014865494"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0168-9525(01)02446-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015592620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1477006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017664485"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.gde.2006.04.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018032111"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg1914",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019069767",
"https://doi.org/10.1038/nrg1914"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg1914",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019069767",
"https://doi.org/10.1038/nrg1914"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.1000480",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021639430"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1266/ggs.77.269",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022643328"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1705",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023508625",
"https://doi.org/10.1038/ng1705"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1705",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023508625",
"https://doi.org/10.1038/ng1705"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.gde.2010.03.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024241037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1343705",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024407499"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0012-1606(83)90201-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024819784"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1637",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025423233",
"https://doi.org/10.1038/ng1637"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1637",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025423233",
"https://doi.org/10.1038/ng1637"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2010.01.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026290690"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03440",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026661886",
"https://doi.org/10.1038/nature03440"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature03440",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026661886",
"https://doi.org/10.1038/nature03440"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0810777105",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026670084"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1399406",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026982051"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1400206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029012312"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0012-1606(76)90119-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029265753"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/86927",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029487229",
"https://doi.org/10.1038/86927"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/86927",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029487229",
"https://doi.org/10.1038/86927"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.94.17.9244",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030291699"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt.1621",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031035095",
"https://doi.org/10.1038/nbt.1621"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09757",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031514558",
"https://doi.org/10.1038/nature09757"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/379131a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031967155",
"https://doi.org/10.1038/379131a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddi112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032427280"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1242/dev.029645",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032682420"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gr.088112.108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036573222"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gr.103200.109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038077860"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/bioinformatics/btp324",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038266369"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1663",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038518105",
"https://doi.org/10.1038/ng1663"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1663",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038518105",
"https://doi.org/10.1038/ng1663"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/gb-2010-11-6-213",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041296325",
"https://doi.org/10.1186/gb-2010-11-6-213"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.1000318",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041637369"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ddrr.81",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041695458"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ddrr.81",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041695458"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.126",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041998321",
"https://doi.org/10.1038/ng.126"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2006.01.044",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042391908"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1091/mbc.e06-03-0170",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042855299"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1196914",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044555726"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1079190",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044897060"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/190372a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048297848",
"https://doi.org/10.1038/190372a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048318512",
"https://doi.org/10.1038/nrg2013"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrg2013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048318512",
"https://doi.org/10.1038/nrg2013"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1756-0500-3-183",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048558651",
"https://doi.org/10.1186/1756-0500-3-183"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1368",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048971359",
"https://doi.org/10.1038/ng1368"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng1368",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048971359",
"https://doi.org/10.1038/ng1368"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/gb-2009-10-3-r25",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049583368",
"https://doi.org/10.1186/gb-2009-10-3-r25"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tig.2005.02.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050908692"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pbio.0050273",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052077401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1190830",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062462476"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1190830",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062462476"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1604317",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062494784"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074985967",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079543670",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.07-10-03059.1987",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079886804"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083055863",
"type": "CreativeWork"
}
],
"datePublished": "2011-12",
"datePublishedReg": "2011-12-01",
"description": "Many animal species use a chromosome-based mechanism of sex determination, which has led to the coordinate evolution of dosage-compensation systems. Dosage compensation not only corrects the imbalance in the number of X chromosomes between the sexes but also is hypothesized to correct dosage imbalance within cells that is due to monoallelic X-linked expression and biallelic autosomal expression, by upregulating X-linked genes twofold (termed 'Ohno's hypothesis'). Although this hypothesis is well supported by expression analyses of individual X-linked genes and by microarray-based transcriptome analyses, it was challenged by a recent study using RNA sequencing and proteomics. We obtained new, independent RNA-seq data, measured RNA polymerase distribution and reanalyzed published expression data in mammals, C. elegans and Drosophila. Our analyses, which take into account the skewed gene content of the X chromosome, support the hypothesis of upregulation of expressed X-linked genes to balance expression of the genome.",
"genre": "research_article",
"id": "sg:pub.10.1038/ng.948",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2691236",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2357962",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2519432",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2699339",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2691239",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2724701",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1103138",
"issn": [
"1061-4036",
"1546-1718"
],
"name": "Nature Genetics",
"type": "Periodical"
},
{
"issueNumber": "12",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "43"
}
],
"name": "Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster",
"pagination": "1179",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b25aba12cce9dcd1a23d07e60e42cb559dff7d7530a7005f9f0d2855caf01a19"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"22019781"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9216904"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ng.948"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1037441343"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ng.948",
"https://app.dimensions.ai/details/publication/pub.1037441343"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T13:00",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000435.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/ng.948"
}
]
Download the RDF metadata as:Â json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.948'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.948'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.948'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.948'
This table displays all metadata directly associated to this object as RDF triples.
484 TRIPLES
21 PREDICATES
111 URIs
42 LITERALS
30 BLANK NODES