Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Xinxian Deng, Joseph B Hiatt, Di Kim Nguyen, Sevinc Ercan, David Sturgill, LaDeana W Hillier, Felix Schlesinger, Carrie A Davis, Valerie J Reinke, Thomas R Gingeras, Jay Shendure, Robert H Waterston, Brian Oliver, Jason D Lieb, Christine M Disteche

ABSTRACT

Many animal species use a chromosome-based mechanism of sex determination, which has led to the coordinate evolution of dosage-compensation systems. Dosage compensation not only corrects the imbalance in the number of X chromosomes between the sexes but also is hypothesized to correct dosage imbalance within cells that is due to monoallelic X-linked expression and biallelic autosomal expression, by upregulating X-linked genes twofold (termed 'Ohno's hypothesis'). Although this hypothesis is well supported by expression analyses of individual X-linked genes and by microarray-based transcriptome analyses, it was challenged by a recent study using RNA sequencing and proteomics. We obtained new, independent RNA-seq data, measured RNA polymerase distribution and reanalyzed published expression data in mammals, C. elegans and Drosophila. Our analyses, which take into account the skewed gene content of the X chromosome, support the hypothesis of upregulation of expressed X-linked genes to balance expression of the genome. More... »

PAGES

1179

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.948

DOI

http://dx.doi.org/10.1038/ng.948

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037441343

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22019781


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