Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-09

AUTHORS

Meng Li, Hong Zhao, Xiaosong Zhang, Laura D Wood, Robert A Anders, Michael A Choti, Timothy M Pawlik, Hubert D Daniel, Rajesh Kannangai, G Johan A Offerhaus, Victor E Velculescu, Linfang Wang, Shibin Zhou, Bert Vogelstein, Ralph H Hruban, Nick Papadopoulos, Jianqiang Cai, Michael S Torbenson, Kenneth W Kinzler

ABSTRACT

Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype. More... »

PAGES

828

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.903

DOI

http://dx.doi.org/10.1038/ng.903

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018806881

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21822264


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