Common variants in ZNF365 are associated with both mammographic density and breast cancer risk View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03

AUTHORS

Sara Lindström, Celine M Vachon, Jingmei Li, Jajini Varghese, Deborah Thompson, Ruth Warren, Judith Brown, Jean Leyland, Tina Audley, Nicholas J Wareham, Ruth J F Loos, Andrew D Paterson, Johanna Rommens, Darryl Waggott, Lisa J Martin, Christopher G Scott, V Shane Pankratz, Susan E Hankinson, Aditi Hazra, David J Hunter, John L Hopper, Melissa C Southey, Stephen J Chanock, Isabel dos Santos Silva, JianJun Liu, Louise Eriksson, Fergus J Couch, Jennifer Stone, Carmel Apicella, Kamila Czene, Peter Kraft, Per Hall, Douglas F Easton, Norman F Boyd, Rulla M Tamimi

ABSTRACT

High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer. More... »

PAGES

185

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.760

DOI

http://dx.doi.org/10.1038/ng.760

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028836856

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21278746


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