Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02

AUTHORS

Sekar Kathiresan, Olle Melander, Candace Guiducci, Aarti Surti, Noël P Burtt, Mark J Rieder, Gregory M Cooper, Charlotta Roos, Benjamin F Voight, Aki S Havulinna, Björn Wahlstrand, Thomas Hedner, Dolores Corella, E Shyong Tai, Jose M Ordovas, Göran Berglund, Erkki Vartiainen, Pekka Jousilahti, Bo Hedblad, Marja-Riitta Taskinen, Christopher Newton-Cheh, Veikko Salomaa, Leena Peltonen, Leif Groop, David M Altshuler, Marju Orho-Melander

ABSTRACT

Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 x 10(-8) for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care. More... »

PAGES

189-197

Journal

TITLE

Nature Genetics

ISSUE

2

VOLUME

40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.75

DOI

http://dx.doi.org/10.1038/ng.75

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013290784

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18193044


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1101", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Biochemistry and Metabolomics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol, HDL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol, LDL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 19", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 7", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Markers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Variation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome, Human", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Linkage Disequilibrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Probability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Randomized Controlled Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Analysis, DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Triglycerides", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.", 
            "Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.", 
            "Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kathiresan", 
        "givenName": "Sekar", 
        "id": "sg:person.0767751267.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767751267.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malm\u00f6, Lund University, Malm\u00f6 20502, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melander", 
        "givenName": "Olle", 
        "id": "sg:person.01226311004.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226311004.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guiducci", 
        "givenName": "Candace", 
        "id": "sg:person.01033730647.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033730647.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Surti", 
        "givenName": "Aarti", 
        "id": "sg:person.0617732370.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617732370.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Burtt", 
        "givenName": "No\u00ebl P", 
        "id": "sg:person.0666045570.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666045570.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rieder", 
        "givenName": "Mark J", 
        "id": "sg:person.015511102702.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015511102702.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cooper", 
        "givenName": "Gregory M", 
        "id": "sg:person.01314025630.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314025630.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malm\u00f6, Lund University, Malm\u00f6 20502, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roos", 
        "givenName": "Charlotta", 
        "id": "sg:person.01150157247.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150157247.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Massachusetts General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.", 
            "Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.", 
            "Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voight", 
        "givenName": "Benjamin F", 
        "id": "sg:person.0653212145.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653212145.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Health and Welfare", 
          "id": "https://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "National Public Health Institute Helsinki 00300, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Havulinna", 
        "givenName": "Aki S", 
        "id": "sg:person.0677736440.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677736440.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sahlgrenska University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1649.a", 
          "name": [
            "Department of Clinical Pharmacology, Sahlgrenska University Hospital, G\u00f6teborg 41345, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wahlstrand", 
        "givenName": "Bj\u00f6rn", 
        "id": "sg:person.01232751170.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232751170.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sahlgrenska University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.1649.a", 
          "name": [
            "Department of Clinical Pharmacology, Sahlgrenska University Hospital, G\u00f6teborg 41345, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hedner", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Valencia", 
          "id": "https://www.grid.ac/institutes/grid.5338.d", 
          "name": [
            "Department of Preventive Medicine, School of Medicine, University of Valencia and CIBER Fisiopatolog\u00eda de la Obesidad y Nutrition, Valencia 46010, Spain."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corella", 
        "givenName": "Dolores", 
        "id": "sg:person.01317275120.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317275120.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Singapore General Hospital", 
          "id": "https://www.grid.ac/institutes/grid.163555.1", 
          "name": [
            "Department of Endocrinology, Singapore General Hospital, 169608 Singapore."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tai", 
        "givenName": "E Shyong", 
        "id": "sg:person.012151130377.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012151130377.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tufts University", 
          "id": "https://www.grid.ac/institutes/grid.429997.8", 
          "name": [
            "Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ordovas", 
        "givenName": "Jose M", 
        "id": "sg:person.013720421742.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013720421742.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Internal Medicine, University Hospital Malm\u00f6, Lund University, Malm\u00f6 20502, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berglund", 
        "givenName": "G\u00f6ran", 
        "id": "sg:person.01313726246.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313726246.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Health and Welfare", 
          "id": "https://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "National Public Health Institute Helsinki 00300, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vartiainen", 
        "givenName": "Erkki", 
        "id": "sg:person.01351306761.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351306761.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Health and Welfare", 
          "id": "https://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "National Public Health Institute Helsinki 00300, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jousilahti", 
        "givenName": "Pekka", 
        "id": "sg:person.0660107161.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660107161.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Epidemiological Research, University Hospital Malm\u00f6, Lund University, Malm\u00f6 20502, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hedblad", 
        "givenName": "Bo", 
        "id": "sg:person.0735025123.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735025123.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Helsinki", 
          "id": "https://www.grid.ac/institutes/grid.7737.4", 
          "name": [
            "Department of Medicine, University of Helsinki, Helsinki 00029, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taskinen", 
        "givenName": "Marja-Riitta", 
        "id": "sg:person.0575621616.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575621616.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.", 
            "Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.", 
            "Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Newton-Cheh", 
        "givenName": "Christopher", 
        "id": "sg:person.0721636067.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721636067.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Health and Welfare", 
          "id": "https://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "National Public Health Institute Helsinki 00300, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Salomaa", 
        "givenName": "Veikko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wellcome Sanger Institute", 
          "id": "https://www.grid.ac/institutes/grid.10306.34", 
          "name": [
            "Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.", 
            "National Public Health Institute Helsinki 00300, Finland.", 
            "Department of Medical Genetics, University of Helsinki, Helsinki 00029, Finland.", 
            "Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peltonen", 
        "givenName": "Leena", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helsinki University Central Hospital", 
          "id": "https://www.grid.ac/institutes/grid.15485.3d", 
          "name": [
            "Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malm\u00f6, Lund University, Malm\u00f6 20502, Sweden.", 
            "Department of Medicine, Helsinki University Hospital, Helsinki 00029, Finland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Groop", 
        "givenName": "Leif", 
        "id": "sg:person.01160545123.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160545123.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.", 
            "Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.", 
            "Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.", 
            "Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.", 
            "Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Altshuler", 
        "givenName": "David M", 
        "id": "sg:person.013764756044.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013764756044.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malm\u00f6, Lund University, Malm\u00f6 20502, Sweden."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orho-Melander", 
        "givenName": "Marju", 
        "id": "sg:person.0743663170.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743663170.81"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.274.13.8832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001415415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003455365", 
          "https://doi.org/10.1038/ng1984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddh119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006584234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2006.06.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006865101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa072366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008342647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.76", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009408087", 
          "https://doi.org/10.1038/ng.76"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(75)91977-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017569475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(75)91977-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017569475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/519795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019061180"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000153341.46271.40", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027028042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa054013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027211528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2005.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027418209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1993.tb00647.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032578394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1993.tb00647.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032578394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000219283.10832.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033482887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000219283.10832.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033482887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035282111", 
          "https://doi.org/10.1038/ng814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035282111", 
          "https://doi.org/10.1038/ng814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2005.05.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042497468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2005.05.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042497468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ije/29.1.49", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043619880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)02526-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046332914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.1370020302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047432867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gepi.1370020302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047432867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.94.9.4532", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049995654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(86)90841-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050870082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/500615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058782730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1064852", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1099870", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062449790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1142358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062456029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci20361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2005-0974", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064288554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-55-1-33", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073720868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074950199", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080066837", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-02", 
    "datePublishedReg": "2008-02-01", 
    "description": "Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 x 10(-8) for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng.75", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "name": "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans", 
    "pagination": "189-197", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3f50ddefdaa325cf2cb62e1be0031a863ec911d3f6a3aae49d9be96d22c545d7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18193044"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng.75"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013290784"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng.75", 
      "https://app.dimensions.ai/details/publication/pub.1013290784"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000422.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ng.75"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.75'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.75'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.75'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.75'


 

This table displays all metadata directly associated to this object as RDF triples.

488 TRIPLES      21 PREDICATES      85 URIs      48 LITERALS      36 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng.75 schema:about N075bd9ecdda447f2887ea7189b4be34d
2 N0eb73a256adb488ba840458fd90cb799
3 N189b6b02377b48c5a3f0de8d47a57e1c
4 N1ae6f8e20f8c426c802d6c12f02b55ef
5 N1cc8dd7b40fd4257981b3215804130d9
6 N2063e017599945f9a8a2030f0e7d625b
7 N215a49ec462e4c62bba487f20f713cb7
8 N2b3a60df43d74fbe8e147630e4e0615e
9 N325137d1749643f3b6415bdcc07bcdd0
10 N3b1fab3faaa04691ab2fbd9cda18a0f9
11 N680060d0abfe48539f1ac147eb1d3c2b
12 N6eb1b3b35ebb4f26b57176b1e181f648
13 N717fd64452534abf94eed59374315635
14 N74d83d0d407240c1a0da3cd04b9fe9ef
15 N75a33730eb7e4213b62d5dcd2721e4e6
16 N7b261bbe110c4467b21df807d0d41535
17 N7dfb4fcc3e5e462aa5f42f5538e43aff
18 N887790d6df8a4ef6a59cefa0962cbeed
19 N8e1f829ff7b444439771cb2cb01ea9a0
20 N99b3d8a7ca874e52ae5afdae55060f0d
21 Nb383cdbd67fc4333b66957439f82860e
22 Nd494bd2b84214eb5b04c519ddcf448ff
23 Ndc735ebcf19646ec811c2a302cd97369
24 Nddf79156d07b42abb82fbdd98b34fb60
25 Ne1e9728adab24babbf4f47091e4d4cbf
26 Ne6d6160cebb44aeebb1ff1ca04775e5e
27 Nff2680e84f5142338a80e957bed95ec2
28 anzsrc-for:11
29 anzsrc-for:1101
30 schema:author N9ceb43e37a5d4232a0e50ca38df04104
31 schema:citation sg:pub.10.1038/ng.76
32 sg:pub.10.1038/ng1984
33 sg:pub.10.1038/ng814
34 https://app.dimensions.ai/details/publication/pub.1074950199
35 https://app.dimensions.ai/details/publication/pub.1080066837
36 https://doi.org/10.1002/gepi.1370020302
37 https://doi.org/10.1016/0092-8674(86)90841-x
38 https://doi.org/10.1016/j.atherosclerosis.2005.05.033
39 https://doi.org/10.1016/j.cmet.2006.06.008
40 https://doi.org/10.1016/j.devcel.2005.04.004
41 https://doi.org/10.1016/s0140-6736(00)02526-5
42 https://doi.org/10.1016/s0140-6736(75)91977-7
43 https://doi.org/10.1056/nejmoa054013
44 https://doi.org/10.1056/nejmoa072366
45 https://doi.org/10.1073/pnas.94.9.4532
46 https://doi.org/10.1074/jbc.274.13.8832
47 https://doi.org/10.1086/500615
48 https://doi.org/10.1086/519795
49 https://doi.org/10.1093/hmg/ddh119
50 https://doi.org/10.1093/ije/29.1.49
51 https://doi.org/10.1111/j.1365-2796.1993.tb00647.x
52 https://doi.org/10.1126/science.1064852
53 https://doi.org/10.1126/science.1099870
54 https://doi.org/10.1126/science.1142358
55 https://doi.org/10.1161/01.atv.0000219283.10832.43
56 https://doi.org/10.1161/01.cir.0000153341.46271.40
57 https://doi.org/10.1172/jci20361
58 https://doi.org/10.1210/jc.2005-0974
59 https://doi.org/10.7326/0003-4819-55-1-33
60 schema:datePublished 2008-02
61 schema:datePublishedReg 2008-02-01
62 schema:description Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular disease. Using genome-wide association data from three studies (n = 8,816 that included 2,758 individuals from the Diabetes Genetics Initiative specific to the current paper as well as 1,874 individuals from the FUSION study of type 2 diabetes and 4,184 individuals from the SardiNIA study of aging-associated variables reported in a companion paper in this issue) and targeted replication association analyses in up to 18,554 independent participants, we show that common SNPs at 18 loci are reproducibly associated with concentrations of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. Six of these loci are new (P < 5 x 10(-8) for each new locus). Of the six newly identified chromosomal regions, two were associated with LDL cholesterol (1p13 near CELSR2, PSRC1 and SORT1 and 19p13 near CILP2 and PBX4), one with HDL cholesterol (1q42 in GALNT2) and five with triglycerides (7q11 near TBL2 and MLXIPL, 8q24 near TRIB1, 1q42 in GALNT2, 19p13 near CILP2 and PBX4 and 1p31 near ANGPTL3). At 1p13, the LDL-associated SNP was also strongly correlated with CELSR2, PSRC1, and SORT1 transcript levels in human liver, and a proxy for this SNP was recently shown to affect risk for coronary artery disease. Understanding the molecular, cellular and clinical consequences of the newly identified loci may inform therapy and clinical care.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N0fe8ff65f35940c4a19c5ada3cfbb741
67 N489745feab264cd6ba95e5775995b001
68 sg:journal.1103138
69 schema:name Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
70 schema:pagination 189-197
71 schema:productId N5f739a1dca8a4a75a3410270a513c538
72 Nab8c45273483450ab57b9e7084f74562
73 Nccc9c991037c48c6b8e726295ef205bc
74 Nd376180f1e7847108ffe147fa662b2a3
75 Nd4c9b28022ac4e0d911eb116d28f1868
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013290784
77 https://doi.org/10.1038/ng.75
78 schema:sdDatePublished 2019-04-10T19:45
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher Ndd166c1f30474b649ada235bea210830
81 schema:url http://www.nature.com/articles/ng.75
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N01f0ea9ad436450dbda1dce03d379876 rdf:first sg:person.01033730647.07
86 rdf:rest N3d2817a5b61140bba3b50d6b0ef0f221
87 N0730299253f646f494a2784786043f59 schema:affiliation https://www.grid.ac/institutes/grid.14758.3f
88 schema:familyName Salomaa
89 schema:givenName Veikko
90 rdf:type schema:Person
91 N075bd9ecdda447f2887ea7189b4be34d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Cohort Studies
93 rdf:type schema:DefinedTerm
94 N0e69458e81164fe8944b37e5c99a47df rdf:first sg:person.01150157247.53
95 rdf:rest Nbd83d7af23b143ecb5d239c3f8ff0c19
96 N0eb73a256adb488ba840458fd90cb799 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Chromosomes, Human, Pair 7
98 rdf:type schema:DefinedTerm
99 N0fe8ff65f35940c4a19c5ada3cfbb741 schema:volumeNumber 40
100 rdf:type schema:PublicationVolume
101 N1096b7dd49fa4afaad39dd2aaf8321b4 schema:name Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, Malmö 20502, Sweden.
102 rdf:type schema:Organization
103 N189b6b02377b48c5a3f0de8d47a57e1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Chromosomes, Human, Pair 8
105 rdf:type schema:DefinedTerm
106 N1ae6f8e20f8c426c802d6c12f02b55ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cholesterol, HDL
108 rdf:type schema:DefinedTerm
109 N1cc8dd7b40fd4257981b3215804130d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Polymorphism, Single Nucleotide
111 rdf:type schema:DefinedTerm
112 N1f29a5cd36a045d782684fde9134c6a2 schema:name Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, Malmö 20502, Sweden.
113 rdf:type schema:Organization
114 N2063e017599945f9a8a2030f0e7d625b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Middle Aged
116 rdf:type schema:DefinedTerm
117 N215a49ec462e4c62bba487f20f713cb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Male
119 rdf:type schema:DefinedTerm
120 N258863178e454c4c88151c3033b55454 rdf:first sg:person.01313726246.87
121 rdf:rest Ncb15fcf85fb746729fa8ce1c4d189428
122 N2743c1e42aba4d6fa602631ee823c4e6 rdf:first sg:person.01160545123.53
123 rdf:rest N668c156e2b34460eb9ca467b615d5877
124 N2b3a60df43d74fbe8e147630e4e0615e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Genetic Markers
126 rdf:type schema:DefinedTerm
127 N2e136455d94d4519804fb808c5d7f9e6 rdf:first sg:person.01317275120.73
128 rdf:rest N94c98a2150874639a5b8688816178a07
129 N325137d1749643f3b6415bdcc07bcdd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Aged
131 rdf:type schema:DefinedTerm
132 N333c792e4a534777a3254feb6ec57cce rdf:first sg:person.0735025123.33
133 rdf:rest N75eb8249a01b4c49b8bb6b94be10a777
134 N38fd238a7001474b879b4170e3acba12 rdf:first sg:person.01232751170.10
135 rdf:rest N643be66c3a2243c3a01545ed075fd677
136 N3b1fab3faaa04691ab2fbd9cda18a0f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Probability
138 rdf:type schema:DefinedTerm
139 N3d2817a5b61140bba3b50d6b0ef0f221 rdf:first sg:person.0617732370.74
140 rdf:rest Ne8dad4b30965415db28c7a9c794f1442
141 N47ec0240309047a1b8d276d4941a6204 rdf:first sg:person.0721636067.97
142 rdf:rest N5b50ceb3508e4414a6b41aa5794177ad
143 N489745feab264cd6ba95e5775995b001 schema:issueNumber 2
144 rdf:type schema:PublicationIssue
145 N4d99cef38f6d47f6a7e8124001298c9f rdf:first sg:person.0743663170.81
146 rdf:rest rdf:nil
147 N5b50ceb3508e4414a6b41aa5794177ad rdf:first N0730299253f646f494a2784786043f59
148 rdf:rest N5c8c6702c29c4ae590ff565885f42c4d
149 N5c8c6702c29c4ae590ff565885f42c4d rdf:first Nc4b8b5a5ff9a44d491e6c4c5111ec554
150 rdf:rest N2743c1e42aba4d6fa602631ee823c4e6
151 N5f739a1dca8a4a75a3410270a513c538 schema:name readcube_id
152 schema:value 3f50ddefdaa325cf2cb62e1be0031a863ec911d3f6a3aae49d9be96d22c545d7
153 rdf:type schema:PropertyValue
154 N631dadaa1d3844b9a0b4d8785a458d11 schema:name Department of Epidemiological Research, University Hospital Malmö, Lund University, Malmö 20502, Sweden.
155 rdf:type schema:Organization
156 N643be66c3a2243c3a01545ed075fd677 rdf:first N64f7baede3fe43b5a5b8a24a15ba73ae
157 rdf:rest N2e136455d94d4519804fb808c5d7f9e6
158 N64f7baede3fe43b5a5b8a24a15ba73ae schema:affiliation https://www.grid.ac/institutes/grid.1649.a
159 schema:familyName Hedner
160 schema:givenName Thomas
161 rdf:type schema:Person
162 N668c156e2b34460eb9ca467b615d5877 rdf:first sg:person.013764756044.24
163 rdf:rest N4d99cef38f6d47f6a7e8124001298c9f
164 N680060d0abfe48539f1ac147eb1d3c2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Case-Control Studies
166 rdf:type schema:DefinedTerm
167 N696201a943584968ac900ca5d19e10d7 rdf:first sg:person.01226311004.18
168 rdf:rest N01f0ea9ad436450dbda1dce03d379876
169 N6eb1b3b35ebb4f26b57176b1e181f648 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Female
171 rdf:type schema:DefinedTerm
172 N717fd64452534abf94eed59374315635 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Genome, Human
174 rdf:type schema:DefinedTerm
175 N74d83d0d407240c1a0da3cd04b9fe9ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Triglycerides
177 rdf:type schema:DefinedTerm
178 N75a33730eb7e4213b62d5dcd2721e4e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Randomized Controlled Trials as Topic
180 rdf:type schema:DefinedTerm
181 N75eb8249a01b4c49b8bb6b94be10a777 rdf:first sg:person.0575621616.10
182 rdf:rest N47ec0240309047a1b8d276d4941a6204
183 N7766677a1b69426cbb92a36626ee3de6 rdf:first sg:person.01314025630.13
184 rdf:rest N0e69458e81164fe8944b37e5c99a47df
185 N7b261bbe110c4467b21df807d0d41535 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Prospective Studies
187 rdf:type schema:DefinedTerm
188 N7dfb4fcc3e5e462aa5f42f5538e43aff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Humans
190 rdf:type schema:DefinedTerm
191 N887790d6df8a4ef6a59cefa0962cbeed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name RNA, Messenger
193 rdf:type schema:DefinedTerm
194 N8e1f829ff7b444439771cb2cb01ea9a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Genetic Variation
196 rdf:type schema:DefinedTerm
197 N93d7f9a4b9574734a7361bb9d5067fa6 schema:name Department of Clinical Sciences, Hypertension and Cardiovascular Diseases, University Hospital Malmö, Lund University, Malmö 20502, Sweden.
198 rdf:type schema:Organization
199 N94c98a2150874639a5b8688816178a07 rdf:first sg:person.012151130377.17
200 rdf:rest Na937c538e0b34de4b65f29a6204821eb
201 N99b3d8a7ca874e52ae5afdae55060f0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Gene Frequency
203 rdf:type schema:DefinedTerm
204 N9ceb43e37a5d4232a0e50ca38df04104 rdf:first sg:person.0767751267.74
205 rdf:rest N696201a943584968ac900ca5d19e10d7
206 Na937c538e0b34de4b65f29a6204821eb rdf:first sg:person.013720421742.60
207 rdf:rest N258863178e454c4c88151c3033b55454
208 Nab5ef3bb444c41819db4f5cadaa0accc schema:name Department of Internal Medicine, University Hospital Malmö, Lund University, Malmö 20502, Sweden.
209 rdf:type schema:Organization
210 Nab8c45273483450ab57b9e7084f74562 schema:name pubmed_id
211 schema:value 18193044
212 rdf:type schema:PropertyValue
213 Nb383cdbd67fc4333b66957439f82860e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Chromosomes, Human, Pair 19
215 rdf:type schema:DefinedTerm
216 Nbd83d7af23b143ecb5d239c3f8ff0c19 rdf:first sg:person.0653212145.73
217 rdf:rest Nc92f3ce50f6b41d3aaf6f80cbba81b40
218 Nc4b8b5a5ff9a44d491e6c4c5111ec554 schema:affiliation https://www.grid.ac/institutes/grid.10306.34
219 schema:familyName Peltonen
220 schema:givenName Leena
221 rdf:type schema:Person
222 Nc92f3ce50f6b41d3aaf6f80cbba81b40 rdf:first sg:person.0677736440.29
223 rdf:rest N38fd238a7001474b879b4170e3acba12
224 Ncb15fcf85fb746729fa8ce1c4d189428 rdf:first sg:person.01351306761.07
225 rdf:rest Nf885ebb78b6449cbb67b96b544ef319b
226 Nccc9c991037c48c6b8e726295ef205bc schema:name dimensions_id
227 schema:value pub.1013290784
228 rdf:type schema:PropertyValue
229 Nd376180f1e7847108ffe147fa662b2a3 schema:name nlm_unique_id
230 schema:value 9216904
231 rdf:type schema:PropertyValue
232 Nd494bd2b84214eb5b04c519ddcf448ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Alleles
234 rdf:type schema:DefinedTerm
235 Nd4c9b28022ac4e0d911eb116d28f1868 schema:name doi
236 schema:value 10.1038/ng.75
237 rdf:type schema:PropertyValue
238 Ndc735ebcf19646ec811c2a302cd97369 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Sequence Analysis, DNA
240 rdf:type schema:DefinedTerm
241 Ndd166c1f30474b649ada235bea210830 schema:name Springer Nature - SN SciGraph project
242 rdf:type schema:Organization
243 Nddf79156d07b42abb82fbdd98b34fb60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
244 schema:name Liver
245 rdf:type schema:DefinedTerm
246 Ne1e9728adab24babbf4f47091e4d4cbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
247 schema:name Chromosomes, Human, Pair 1
248 rdf:type schema:DefinedTerm
249 Ne6d6160cebb44aeebb1ff1ca04775e5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
250 schema:name Linkage Disequilibrium
251 rdf:type schema:DefinedTerm
252 Ne8dad4b30965415db28c7a9c794f1442 rdf:first sg:person.0666045570.58
253 rdf:rest Nf2208007e7ee47f8b377d2a38ffc825f
254 Nf2208007e7ee47f8b377d2a38ffc825f rdf:first sg:person.015511102702.87
255 rdf:rest N7766677a1b69426cbb92a36626ee3de6
256 Nf885ebb78b6449cbb67b96b544ef319b rdf:first sg:person.0660107161.47
257 rdf:rest N333c792e4a534777a3254feb6ec57cce
258 Nff2680e84f5142338a80e957bed95ec2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
259 schema:name Cholesterol, LDL
260 rdf:type schema:DefinedTerm
261 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
262 schema:name Medical and Health Sciences
263 rdf:type schema:DefinedTerm
264 anzsrc-for:1101 schema:inDefinedTermSet anzsrc-for:
265 schema:name Medical Biochemistry and Metabolomics
266 rdf:type schema:DefinedTerm
267 sg:journal.1103138 schema:issn 1061-4036
268 1546-1718
269 schema:name Nature Genetics
270 rdf:type schema:Periodical
271 sg:person.01033730647.07 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
272 schema:familyName Guiducci
273 schema:givenName Candace
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033730647.07
275 rdf:type schema:Person
276 sg:person.01150157247.53 schema:affiliation N1f29a5cd36a045d782684fde9134c6a2
277 schema:familyName Roos
278 schema:givenName Charlotta
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150157247.53
280 rdf:type schema:Person
281 sg:person.01160545123.53 schema:affiliation https://www.grid.ac/institutes/grid.15485.3d
282 schema:familyName Groop
283 schema:givenName Leif
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160545123.53
285 rdf:type schema:Person
286 sg:person.012151130377.17 schema:affiliation https://www.grid.ac/institutes/grid.163555.1
287 schema:familyName Tai
288 schema:givenName E Shyong
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012151130377.17
290 rdf:type schema:Person
291 sg:person.01226311004.18 schema:affiliation N93d7f9a4b9574734a7361bb9d5067fa6
292 schema:familyName Melander
293 schema:givenName Olle
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226311004.18
295 rdf:type schema:Person
296 sg:person.01232751170.10 schema:affiliation https://www.grid.ac/institutes/grid.1649.a
297 schema:familyName Wahlstrand
298 schema:givenName Björn
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232751170.10
300 rdf:type schema:Person
301 sg:person.01313726246.87 schema:affiliation Nab5ef3bb444c41819db4f5cadaa0accc
302 schema:familyName Berglund
303 schema:givenName Göran
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313726246.87
305 rdf:type schema:Person
306 sg:person.01314025630.13 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
307 schema:familyName Cooper
308 schema:givenName Gregory M
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314025630.13
310 rdf:type schema:Person
311 sg:person.01317275120.73 schema:affiliation https://www.grid.ac/institutes/grid.5338.d
312 schema:familyName Corella
313 schema:givenName Dolores
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317275120.73
315 rdf:type schema:Person
316 sg:person.01351306761.07 schema:affiliation https://www.grid.ac/institutes/grid.14758.3f
317 schema:familyName Vartiainen
318 schema:givenName Erkki
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351306761.07
320 rdf:type schema:Person
321 sg:person.013720421742.60 schema:affiliation https://www.grid.ac/institutes/grid.429997.8
322 schema:familyName Ordovas
323 schema:givenName Jose M
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013720421742.60
325 rdf:type schema:Person
326 sg:person.013764756044.24 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
327 schema:familyName Altshuler
328 schema:givenName David M
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013764756044.24
330 rdf:type schema:Person
331 sg:person.015511102702.87 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
332 schema:familyName Rieder
333 schema:givenName Mark J
334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015511102702.87
335 rdf:type schema:Person
336 sg:person.0575621616.10 schema:affiliation https://www.grid.ac/institutes/grid.7737.4
337 schema:familyName Taskinen
338 schema:givenName Marja-Riitta
339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0575621616.10
340 rdf:type schema:Person
341 sg:person.0617732370.74 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
342 schema:familyName Surti
343 schema:givenName Aarti
344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617732370.74
345 rdf:type schema:Person
346 sg:person.0653212145.73 schema:affiliation https://www.grid.ac/institutes/grid.32224.35
347 schema:familyName Voight
348 schema:givenName Benjamin F
349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653212145.73
350 rdf:type schema:Person
351 sg:person.0660107161.47 schema:affiliation https://www.grid.ac/institutes/grid.14758.3f
352 schema:familyName Jousilahti
353 schema:givenName Pekka
354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660107161.47
355 rdf:type schema:Person
356 sg:person.0666045570.58 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
357 schema:familyName Burtt
358 schema:givenName Noël P
359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666045570.58
360 rdf:type schema:Person
361 sg:person.0677736440.29 schema:affiliation https://www.grid.ac/institutes/grid.14758.3f
362 schema:familyName Havulinna
363 schema:givenName Aki S
364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677736440.29
365 rdf:type schema:Person
366 sg:person.0721636067.97 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
367 schema:familyName Newton-Cheh
368 schema:givenName Christopher
369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721636067.97
370 rdf:type schema:Person
371 sg:person.0735025123.33 schema:affiliation N631dadaa1d3844b9a0b4d8785a458d11
372 schema:familyName Hedblad
373 schema:givenName Bo
374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735025123.33
375 rdf:type schema:Person
376 sg:person.0743663170.81 schema:affiliation N1096b7dd49fa4afaad39dd2aaf8321b4
377 schema:familyName Orho-Melander
378 schema:givenName Marju
379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743663170.81
380 rdf:type schema:Person
381 sg:person.0767751267.74 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
382 schema:familyName Kathiresan
383 schema:givenName Sekar
384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767751267.74
385 rdf:type schema:Person
386 sg:pub.10.1038/ng.76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009408087
387 https://doi.org/10.1038/ng.76
388 rdf:type schema:CreativeWork
389 sg:pub.10.1038/ng1984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003455365
390 https://doi.org/10.1038/ng1984
391 rdf:type schema:CreativeWork
392 sg:pub.10.1038/ng814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035282111
393 https://doi.org/10.1038/ng814
394 rdf:type schema:CreativeWork
395 https://app.dimensions.ai/details/publication/pub.1074950199 schema:CreativeWork
396 https://app.dimensions.ai/details/publication/pub.1080066837 schema:CreativeWork
397 https://doi.org/10.1002/gepi.1370020302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047432867
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1016/0092-8674(86)90841-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050870082
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1016/j.atherosclerosis.2005.05.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042497468
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1016/j.cmet.2006.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006865101
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1016/j.devcel.2005.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027418209
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1016/s0140-6736(00)02526-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046332914
408 rdf:type schema:CreativeWork
409 https://doi.org/10.1016/s0140-6736(75)91977-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017569475
410 rdf:type schema:CreativeWork
411 https://doi.org/10.1056/nejmoa054013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027211528
412 rdf:type schema:CreativeWork
413 https://doi.org/10.1056/nejmoa072366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008342647
414 rdf:type schema:CreativeWork
415 https://doi.org/10.1073/pnas.94.9.4532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049995654
416 rdf:type schema:CreativeWork
417 https://doi.org/10.1074/jbc.274.13.8832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001415415
418 rdf:type schema:CreativeWork
419 https://doi.org/10.1086/500615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058782730
420 rdf:type schema:CreativeWork
421 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
422 rdf:type schema:CreativeWork
423 https://doi.org/10.1093/hmg/ddh119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006584234
424 rdf:type schema:CreativeWork
425 https://doi.org/10.1093/ije/29.1.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043619880
426 rdf:type schema:CreativeWork
427 https://doi.org/10.1111/j.1365-2796.1993.tb00647.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032578394
428 rdf:type schema:CreativeWork
429 https://doi.org/10.1126/science.1064852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445448
430 rdf:type schema:CreativeWork
431 https://doi.org/10.1126/science.1099870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449790
432 rdf:type schema:CreativeWork
433 https://doi.org/10.1126/science.1142358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062456029
434 rdf:type schema:CreativeWork
435 https://doi.org/10.1161/01.atv.0000219283.10832.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033482887
436 rdf:type schema:CreativeWork
437 https://doi.org/10.1161/01.cir.0000153341.46271.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027028042
438 rdf:type schema:CreativeWork
439 https://doi.org/10.1172/jci20361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416539
440 rdf:type schema:CreativeWork
441 https://doi.org/10.1210/jc.2005-0974 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064288554
442 rdf:type schema:CreativeWork
443 https://doi.org/10.7326/0003-4819-55-1-33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073720868
444 rdf:type schema:CreativeWork
445 https://www.grid.ac/institutes/grid.10306.34 schema:alternateName Wellcome Sanger Institute
446 schema:name Department of Medical Genetics, University of Helsinki, Helsinki 00029, Finland.
447 National Public Health Institute Helsinki 00300, Finland.
448 Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
449 Wellcome Trust Sanger Institute, Cambridge CB10 1SA, UK.
450 rdf:type schema:Organization
451 https://www.grid.ac/institutes/grid.14758.3f schema:alternateName National Institute for Health and Welfare
452 schema:name National Public Health Institute Helsinki 00300, Finland.
453 rdf:type schema:Organization
454 https://www.grid.ac/institutes/grid.15485.3d schema:alternateName Helsinki University Central Hospital
455 schema:name Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Malmö, Lund University, Malmö 20502, Sweden.
456 Department of Medicine, Helsinki University Hospital, Helsinki 00029, Finland.
457 rdf:type schema:Organization
458 https://www.grid.ac/institutes/grid.163555.1 schema:alternateName Singapore General Hospital
459 schema:name Department of Endocrinology, Singapore General Hospital, 169608 Singapore.
460 rdf:type schema:Organization
461 https://www.grid.ac/institutes/grid.1649.a schema:alternateName Sahlgrenska University Hospital
462 schema:name Department of Clinical Pharmacology, Sahlgrenska University Hospital, Göteborg 41345, Sweden.
463 rdf:type schema:Organization
464 https://www.grid.ac/institutes/grid.32224.35 schema:alternateName Massachusetts General Hospital
465 schema:name Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
466 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
467 Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
468 rdf:type schema:Organization
469 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
470 schema:name Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
471 rdf:type schema:Organization
472 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
473 schema:name Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
474 Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
475 Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
476 Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
477 Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
478 Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
479 rdf:type schema:Organization
480 https://www.grid.ac/institutes/grid.429997.8 schema:alternateName Tufts University
481 schema:name Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA.
482 rdf:type schema:Organization
483 https://www.grid.ac/institutes/grid.5338.d schema:alternateName University of Valencia
484 schema:name Department of Preventive Medicine, School of Medicine, University of Valencia and CIBER Fisiopatología de la Obesidad y Nutrition, Valencia 46010, Spain.
485 rdf:type schema:Organization
486 https://www.grid.ac/institutes/grid.7737.4 schema:alternateName University of Helsinki
487 schema:name Department of Medicine, University of Helsinki, Helsinki 00029, Finland.
488 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...