Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-11-14

AUTHORS

Nona Sotoodehnia, Aaron Isaacs, Paul I W de Bakker, Marcus Dörr, Christopher Newton-Cheh, Ilja M Nolte, Pim van der Harst, Martina Müller, Mark Eijgelsheim, Alvaro Alonso, Andrew A Hicks, Sandosh Padmanabhan, Caroline Hayward, Albert Vernon Smith, Ozren Polasek, Steven Giovannone, Jingyuan Fu, Jared W Magnani, Kristin D Marciante, Arne Pfeufer, Sina A Gharib, Alexander Teumer, Man Li, Joshua C Bis, Fernando Rivadeneira, Thor Aspelund, Anna Köttgen, Toby Johnson, Kenneth Rice, Mark P S Sie, Ying A Wang, Norman Klopp, Christian Fuchsberger, Sarah H Wild, Irene Mateo Leach, Karol Estrada, Uwe Völker, Alan F Wright, Folkert W Asselbergs, Jiaxiang Qu, Aravinda Chakravarti, Moritz F Sinner, Jan A Kors, Astrid Petersmann, Tamara B Harris, Elsayed Z Soliman, Patricia B Munroe, Bruce M Psaty, Ben A Oostra, L Adrienne Cupples, Siegfried Perz, Rudolf A de Boer, André G Uitterlinden, Henry Völzke, Timothy D Spector, Fang-Yu Liu, Eric Boerwinkle, Anna F Dominiczak, Jerome I Rotter, Gé van Herpen, Daniel Levy, H-Erich Wichmann, Wiek H van Gilst, Jacqueline C M Witteman, Heyo K Kroemer, W H Linda Kao, Susan R Heckbert, Thomas Meitinger, Albert Hofman, Harry Campbell, Aaron R Folsom, Dirk J van Veldhuisen, Christine Schwienbacher, Christopher J O'Donnell, Claudia Beu Volpato, Mark J Caulfield, John M Connell, Lenore Launer, Xiaowen Lu, Lude Franke, Rudolf S N Fehrmann, Gerard te Meerman, Harry J M Groen, Rinse K Weersma, Leonard H van den Berg, Cisca Wijmenga, Roel A Ophoff, Gerjan Navis, Igor Rudan, Harold Snieder, James F Wilson, Peter P Pramstaller, David S Siscovick, Thomas J Wang, Vilmundur Gudnason, Cornelia M van Duijn, Stephan B Felix, Glenn I Fishman, Yalda Jamshidi, Bruno H Ch Stricker, Nilesh J Samani, Stefan Kääb, Dan E Arking

ABSTRACT

Nona Sotoodehnia and colleagues report a meta-analysis of 14 genome-wide association studies for QRS interval, an electrocardiogram measurement of cardiac ventricular conduction. They identify 22 loci associated with QRS duration.

PAGES

1068-1076

References to SciGraph publications

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    12

    VOLUME

    42

    Author Affiliations

  • Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
  • Centre for Medical Systems Biology, Leiden, The Netherlands
  • Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
  • Department of Internal Medicine B, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • National Heart, Lung, and Blood Institute's (NHLBI) Framingham Heart Study, Framingham, Massachusetts, USA
  • Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  • Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
  • Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany
  • Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
  • Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
  • Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano, Italy, affiliated institute of the University of Lübeck, Germany.
  • Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, University Place, Glasgow, UK
  • Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, Edinburgh, UK
  • University of Iceland, Reykjavik, Iceland
  • Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia
  • Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA
  • Department of Genetics, University Medical Center Groningen, University of Groningen, The Netherlands
  • Section of Cardiovascular Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
  • Institute of Human Genetics, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
  • Department of Medicine, Center for Lung Biology, University of Washington, Seattle, Washington, USA
  • Interfaculty Institute for Genetics and Functional Genomics, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Department of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, Maryland, USA
  • Department of Internal Medicine, ErasmusRotterdam, MC, The Netherlands
  • Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
  • Barts and the London National Institute of Health Research Cardiovascular Biomedical Research Unit, London, UK
  • Department of Biostatistics, University of Washington, Seattle, Washington, USA
  • Department of Epidemiology, Genetic Epidemiology Unit, Erasmus Medical Center (MC), Rotterdam, The Netherlands
  • Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
  • Centre for Population Health Sciences, University of Edinburgh, Edinburgh, Scotland
  • Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
  • McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  • Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, Munich, Germany
  • Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands.
  • Institute of Clinical Chemistry and Laboratory Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
  • Epidemiological Cardiology Research Center (EPICARE), Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
  • Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA
  • Department of Clinical Genetics, ErasmusRotterdam, MC, The Netherlands
  • Institute for Biological and Medical Imaging, Helmholtz Zentrum München-German Research Center for Environmental Health,, Neuherberg, Germany
  • Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands
  • Institute for Community Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Department of Twin Research and Genetic Epidemiology Unit, St. Thomas' Campus, King's College London, St. Thomas' Hospital, London, UK
  • Institute for Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
  • Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
  • National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
  • Klinikum Grosshadern, Munich, Germany
  • Department of Pharmacology, Center for Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University Greifswald, Greifswald, Germany
  • Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
  • University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
  • Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  • Department of Pulmonology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Department of Neurology, Rudolf Magnus Institute, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands
  • Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA
  • Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
  • Gen-info Ltd, Zagreb, Croatia
  • Department of Neurology, University of Lübeck, Lübeck, Germany
  • Department of Epidemiology, University of Washington, Seattle, Washington, USA
  • Division of Clinical Developmental Sciences, St. George's University of London, London, UK
  • Inspectorate of Health Care, The Hague, The Netherlands
  • Leicester NIHR Biomedical Research Unit in Cardiovascular Disease Glenfield Hospital, Leicester, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.716

    DOI

    http://dx.doi.org/10.1038/ng.716

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042403145

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21076409


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