Phylogenetic diversity and historical patterns of pandemic spread of Yersinia pestis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-10-31

AUTHORS

Giovanna Morelli, Yajun Song, Camila J. Mazzoni, Mark Eppinger, Philippe Roumagnac, David M. Wagner, Mirjam Feldkamp, Barica Kusecek, Amy J. Vogler, Yanjun Li, Yujun Cui, Nicholas R. Thomson, Thibaut Jombart, Raphael Leblois, Peter Lichtner, Lila Rahalison, Jeannine M. Petersen, Francois Balloux, Paul Keim, Thierry Wirth, Jacques Ravel, Ruifu Yang, Elisabeth Carniel, Mark Achtman

ABSTRACT

Plague is a pandemic human invasive disease caused by the bacterial agent Yersinia pestis. We here report a comparison of 17 whole genomes of Y. pestis isolates from global sources. We also screened a global collection of 286 Y. pestis isolates for 933 SNPs using Sequenom MassArray SNP typing. We conducted phylogenetic analyses on this sequence variation dataset, assigned isolates to populations based on maximum parsimony and, from these results, made inferences regarding historical transmission routes. Our phylogenetic analysis suggests that Y. pestis evolved in or near China and spread through multiple radiations to Europe, South America, Africa and Southeast Asia, leading to country-specific lineages that can be traced by lineage-specific SNPs. All 626 current isolates from the United States reflect one radiation, and 82 isolates from Madagascar represent a second radiation. Subsequent local microevolution of Y. pestis is marked by sequential, geographically specific SNPs. More... »

PAGES

1140-1143

Journal

TITLE

Nature Genetics

ISSUE

12

VOLUME

42

Author Affiliations

  • Max-Planck-Institut für Infektionsbiologie, Dept. of Molecular Biology, Charitéplatz 1, 10117 Berlin, Germany
  • Environmental Research Institute, University College Cork, Cork, Ireland
  • Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, U.S.A.
  • Centre de Coopération Internationale en Recherche Agronomique pour le Développement, UMR BGPI, 34398 Montpellier Cedex 5, France
  • Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011-5640, U.S.A.
  • State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
  • The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SA, UK
  • MRC Centre for Outbreak Analysis and Modelling, Imperial College Faculty of Medicine, London W21PG, UK
  • Muséum National d'Histoire Naturelle - EPHE Department of Systematics and Evolution UMR-CNRS 7205, 75231 Paris, France
  • Institute of Human Genetics, German Research Center for Environmental Health, D-85764 Neuherberg, Germany
  • Unité Peste, Institut Pasteur de Madagascar, BP 1274 - 101, Madagascar
  • Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, 80521, U.S.A.
  • Pathogen Genomics Division, Translational Genomics Research Institute, Phoenix, AZ 85404, U.S.A.
  • Institut Pasteur, Yersinia Research Unit, 28 rue du Dr. Roux, Paris, France.
  • Dept. of Microbiology, University College Cork, Cork, Ireland
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.705

    DOI

    http://dx.doi.org/10.1038/ng.705

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015236659

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21037571


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