Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09

AUTHORS

Hongxing Zhang, Yun Zhai, Zhibin Hu, Chen Wu, Ji Qian, Weihua Jia, Fuchao Ma, Wenfeng Huang, Lixia Yu, Wei Yue, Zhifu Wang, Peiyao Li, Yang Zhang, Renxiang Liang, Zhongliang Wei, Ying Cui, Weimin Xie, Mi Cai, Xinsen Yu, Yunfei Yuan, Xia Xia, Xiumei Zhang, Hao Yang, Wei Qiu, Jingmin Yang, Feng Gong, Minshan Chen, Hongbing Shen, Dongxin Lin, Yi-Xin Zeng, Fuchu He, Gangqiao Zhou

ABSTRACT

To identify susceptibility variants for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), we conducted a genome-wide association study by genotyping 440,794 SNPs in 355 chronic HBV carriers with HCC and 360 chronic HBV carriers without HCC, all of Chinese ancestry. We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios. Across the six studies, the association with rs17401966 was highly statistically significant (joint odds ratio = 0.61, P = 1.7 x 10(-18)). In addition to KIF1B, the association region tagged two other plausible causative genes, UBE4B and PGD. Our findings provide evidence that the 1p36.22 locus confers susceptibility to HBV-related HCC, and suggest that KIF1B-, UBE4B- or PGD-related pathways might be involved in the pathogenesis of this malignancy. More... »

PAGES

755

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.638

DOI

http://dx.doi.org/10.1038/ng.638

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043027005

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20676096


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484 MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
485 State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.
486 rdf:type schema:Organization
487 https://www.grid.ac/institutes/grid.89957.3a schema:alternateName Nanjing Medical University
488 schema:name Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China.
489 rdf:type schema:Organization
 




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