Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-08

AUTHORS

Nobuhisa Mizuki, Akira Meguro, Masao Ota, Shigeaki Ohno, Tomoko Shiota, Tatsukata Kawagoe, Norihiko Ito, Jiro Kera, Eiichi Okada, Keisuke Yatsu, Yeong-Wook Song, Eun-Bong Lee, Nobuyoshi Kitaichi, Kenichi Namba, Yukihiro Horie, Mitsuhiro Takeno, Sunao Sugita, Manabu Mochizuki, Seiamak Bahram, Yoshiaki Ishigatsubo, Hidetoshi Inoko

ABSTRACT

Behçet's disease is a chronic systemic inflammatory disorder characterized by four major manifestations: recurrent ocular symptoms, oral and genital ulcers and skin lesions. We conducted a genome-wide association study in a Japanese cohort including 612 individuals with Behçet's disease and 740 unaffected individuals (controls). We identified two suggestive associations on chromosomes 1p31.3 (IL23R-IL12RB2, rs12119179, P = 2.7 x 10(-8)) and 1q32.1 (IL10, rs1554286, P = 8.0 x 10(-8)). A meta-analysis of these two loci with results from additional Turkish and Korean cohorts showed genome-wide significant associations (rs1495965 in IL23R-IL12RB2, P = 1.9 x 10(-11), odds ratio = 1.35; rs1800871 in IL10, P = 1.0 x 10(-14), odds ratio = 1.45). More... »

PAGES

703

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.624

DOI

http://dx.doi.org/10.1038/ng.624

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005574545

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20622879


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.624'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.624'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.624'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.624'


 

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