Genetic variation in human HBB is associated with Plasmodium falciparum transmission View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-04

AUTHORS

Louis Clement Gouagna, Germana Bancone, Frank Yao, Bienvenue Yameogo, Kounbobr Roch Dabiré, Carlo Costantini, Jacques Simporé, Jean Bosco Ouedraogo, David Modiano

ABSTRACT

Genetic factors are known to have a role in determining susceptibility to infectious diseases, although it is unclear whether they may also influence host efficiency in transmitting pathogens. We examine variants in HBB that have been shown to be protective against malaria and test whether these are associated with the transmission of the parasite from the human host to the Anopheles vector. We conducted cross-sectional malariological surveys on 3,739 human subjects and transmission experiments involving 60 children and 6,446 mosquitoes in Burkina Faso, West Africa. Protective hemoglobins C (HbC, beta6Glu-->Lys) and S (beta6Glu-->Val) are associated with a twofold in vivo (odds ratio 2.17, 95% CI 1.57-3.01, P = 1.0 x 10(-6)) and a fourfold ex vivo (odds ratio 4.12, 95% CI 1.90-9.29, P = 7.0 x 10(-5)) increase of parasite transmission from the human host to the Anopheles vector. This provides an example of how host genetic variation may influence the transmission dynamics of an infectious disease. More... »

PAGES

328

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.554

DOI

http://dx.doi.org/10.1038/ng.554

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023842929

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20305663


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.554'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.554'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.554'


 

This table displays all metadata directly associated to this object as RDF triples.

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