Genome-wide association study of hematological and biochemical traits in a Japanese population View Full Text


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Article Info

DATE

2010-03

AUTHORS

Yoichiro Kamatani, Koichi Matsuda, Yukinori Okada, Michiaki Kubo, Naoya Hosono, Yataro Daigo, Yusuke Nakamura, Naoyuki Kamatani

ABSTRACT

We report genome-wide association studies for hematological and biochemical traits from approximately 14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P < 5 x 10(-8)). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was >10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated. More... »

PAGES

210

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.531

    DOI

    http://dx.doi.org/10.1038/ng.531

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004197131

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20139978


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