Identification of DOK genes as lung tumor suppressors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-03

AUTHORS

Alice H Berger, Masaru Niki, Alessandro Morotti, Barry S Taylor, Nicholas D Socci, Agnes Viale, Cameron Brennan, Janos Szoke, Noriko Motoi, Paul B Rothman, Julie Teruya-Feldstein, William L Gerald, Marc Ladanyi, Pier Paolo Pandolfi

ABSTRACT

Genome-wide analyses of human lung adenocarcinoma have identified regions of consistent copy-number gain or loss, but in many cases the oncogenes and tumor suppressors presumed to reside in these loci remain to be determined. Here we identify the downstream of tyrosine kinase (Dok) family members Dok1, Dok2 and Dok3 as lung tumor suppressors. Single, double or triple compound loss of these genes in mice results in lung cancer, with penetrance and latency dependent on the number of lost Dok alleles. Cancer development is preceded by an aberrant expansion and signaling profile of alveolar type II cells and bronchioalveolar stem cells. In human lung adenocarcinoma, we identify DOK2 as a target of copy-number loss and mRNA downregulation and find that DOK2 suppresses lung cancer cell proliferation in vitro and in vivo. Given the genomic localization of DOK2, we propose it as an 8p21.3 haploinsufficient human lung tumor suppressor. More... »

PAGES

216

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ng.527

DOI

http://dx.doi.org/10.1038/ng.527

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009971742

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20139980


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Tumor Suppressor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transplantation, Heterologous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Burden", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.", 
            "Cancer Biology and Genetics Program, Sloan-Kettering Institute, New York, New York, USA.", 
            "Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.", 
            "Weill Graduate School of Medical Sciences, Cornell University, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berger", 
        "givenName": "Alice H", 
        "id": "sg:person.0602422363.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602422363.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Iowa", 
          "id": "https://www.grid.ac/institutes/grid.214572.7", 
          "name": [
            "Cancer Biology and Genetics Program, Sloan-Kettering Institute, New York, New York, USA.", 
            "Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.", 
            "Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Niki", 
        "givenName": "Masaru", 
        "id": "sg:person.0765424143.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765424143.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.", 
            "Cancer Biology and Genetics Program, Sloan-Kettering Institute, New York, New York, USA.", 
            "Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morotti", 
        "givenName": "Alessandro", 
        "id": "sg:person.01313536640.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313536640.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taylor", 
        "givenName": "Barry S", 
        "id": "sg:person.01333376013.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333376013.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Bioinformatics Core, Sloan-Kettering Institute, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Socci", 
        "givenName": "Nicholas D", 
        "id": "sg:person.010357032237.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010357032237.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Genomics Core Laboratory, Sloan-Kettering Institute, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Viale", 
        "givenName": "Agnes", 
        "id": "sg:person.0712021032.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712021032.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.", 
            "Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brennan", 
        "givenName": "Cameron", 
        "id": "sg:person.01062522214.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062522214.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Szoke", 
        "givenName": "Janos", 
        "id": "sg:person.01155670023.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155670023.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Motoi", 
        "givenName": "Noriko", 
        "id": "sg:person.01004527100.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004527100.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Iowa", 
          "id": "https://www.grid.ac/institutes/grid.214572.7", 
          "name": [
            "Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rothman", 
        "givenName": "Paul B", 
        "id": "sg:person.01006355642.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006355642.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Teruya-Feldstein", 
        "givenName": "Julie", 
        "id": "sg:person.0744143643.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744143643.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.", 
            "Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gerald", 
        "givenName": "William L", 
        "id": "sg:person.01162424060.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162424060.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Memorial Sloan Kettering Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.51462.34", 
          "name": [
            "Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.", 
            "Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ladanyi", 
        "givenName": "Marc", 
        "id": "sg:person.01146507367.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146507367.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.", 
            "Cancer Biology and Genetics Program, Sloan-Kettering Institute, New York, New York, USA.", 
            "Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.", 
            "Weill Graduate School of Medical Sciences, Cornell University, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pandolfi", 
        "givenName": "Pier Paolo", 
        "id": "sg:person.01355745464.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355745464.73"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0960-9822(99)80458-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000695296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002754114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.200102032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003613500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0504126102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006175044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.03.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006708194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.03.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006708194"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.943001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007211161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.19.12.8314", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007276801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)61257-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009312131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010933002", 
          "https://doi.org/10.1038/sj.onc.1207947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010933002", 
          "https://doi.org/10.1038/sj.onc.1207947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m403726200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015008529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1476-5586(04)80047-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019351767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature06358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019681472", 
          "https://doi.org/10.1038/nature06358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81840-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021110000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci31854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024226963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.3.275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026006079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1532/ijh97.05144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026541312", 
          "https://doi.org/10.1532/ijh97.05144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1532/ijh97.05144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026541312", 
          "https://doi.org/10.1532/ijh97.05144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81841-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029007273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2164-8-140", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033033278", 
          "https://doi.org/10.1186/1471-2164-8-140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/19.19.5114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033404333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/88.22.1676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038758389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00022744-200206000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038850955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00022744-200206000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038850955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/intimm/dxm015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039080457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-06-4517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041137532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045393486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2005.02.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047408290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129039-200206000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047460585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00129039-200206000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047460585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049951245", 
          "https://doi.org/10.1038/onc.2009.135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2009.135", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049951245", 
          "https://doi.org/10.1038/onc.2009.135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050222108", 
          "https://doi.org/10.1038/ng2037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.9.4827", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050439208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-10-055194", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051049280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.26.7.2479-2489.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051058539"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/gcc.2870070204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051575092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.176.7.3958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051715080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20041306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052469899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jb/mvm127", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059745762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1127142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062453749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074361777", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074578264", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075839608", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077005561", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082424623", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082807381", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-03", 
    "datePublishedReg": "2010-03-01", 
    "description": "Genome-wide analyses of human lung adenocarcinoma have identified regions of consistent copy-number gain or loss, but in many cases the oncogenes and tumor suppressors presumed to reside in these loci remain to be determined. Here we identify the downstream of tyrosine kinase (Dok) family members Dok1, Dok2 and Dok3 as lung tumor suppressors. Single, double or triple compound loss of these genes in mice results in lung cancer, with penetrance and latency dependent on the number of lost Dok alleles. Cancer development is preceded by an aberrant expansion and signaling profile of alveolar type II cells and bronchioalveolar stem cells. In human lung adenocarcinoma, we identify DOK2 as a target of copy-number loss and mRNA downregulation and find that DOK2 suppresses lung cancer cell proliferation in vitro and in vivo. Given the genomic localization of DOK2, we propose it as an 8p21.3 haploinsufficient human lung tumor suppressor.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ng.527", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2435846", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2480693", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2479742", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435641", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1103138", 
        "issn": [
          "1061-4036", 
          "1546-1718"
        ], 
        "name": "Nature Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "42"
      }
    ], 
    "name": "Identification of DOK genes as lung tumor suppressors", 
    "pagination": "216", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2f8163bd8b90426807e01b90a8a40621671be8915de1bdf55369f03b42fe6db6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20139980"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9216904"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ng.527"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009971742"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ng.527", 
      "https://app.dimensions.ai/details/publication/pub.1009971742"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000347_0000000347/records_89824_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ng.527"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ng.527'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ng.527'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ng.527'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ng.527'


 

This table displays all metadata directly associated to this object as RDF triples.

384 TRIPLES      21 PREDICATES      89 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ng.527 schema:about N1b44edd954a140bfb0104ac304605787
2 N1b675b21dcc24080b9381bdb53306f8c
3 N23044c522cf94f2e98756f8f1e6e6829
4 N2c39991a86f44bb0840c5ca55e31eabb
5 N326d8fdee5d4470d92f08ed94402893f
6 N3359f4db876b437093f7709bccbb5f81
7 N466347b5cc5647468b5a72af41887537
8 N4b09066476c04e1ea369726d890b8b10
9 N6c27afd9cdbf43ceaf7b3ce8c3da516e
10 N78af7a1870b348fa84560ba5027aca64
11 N7e679c26e0e84d0d933734dd2e666a39
12 N859dea89c9d2452994dc4eff80685cc8
13 N89a557f279964c4c80c34f78d29638a2
14 N9a55ede9f8a14568b92e4fffb92bda54
15 Ne537c560139b454e8fc7c73d0ef5938a
16 Neb004d93eb994ce686aeec1ab71b8c8d
17 Nee17817d86c9448d8aa88a2abc59aa95
18 Needf834c17b14d879da5e1b23b69a607
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Nae0cb84db98e401a9b99a850277b24ef
22 schema:citation sg:pub.10.1038/nature06358
23 sg:pub.10.1038/ng2037
24 sg:pub.10.1038/onc.2009.135
25 sg:pub.10.1038/sj.onc.1207947
26 sg:pub.10.1186/1471-2164-8-140
27 sg:pub.10.1532/ijh97.05144
28 https://app.dimensions.ai/details/publication/pub.1074361777
29 https://app.dimensions.ai/details/publication/pub.1074578264
30 https://app.dimensions.ai/details/publication/pub.1075839608
31 https://app.dimensions.ai/details/publication/pub.1077005561
32 https://app.dimensions.ai/details/publication/pub.1082424623
33 https://app.dimensions.ai/details/publication/pub.1082807381
34 https://doi.org/10.1002/gcc.2870070204
35 https://doi.org/10.1016/j.cell.2005.02.031
36 https://doi.org/10.1016/j.cell.2005.03.032
37 https://doi.org/10.1016/s0002-9440(10)61257-6
38 https://doi.org/10.1016/s0092-8674(00)81840-1
39 https://doi.org/10.1016/s0092-8674(00)81841-3
40 https://doi.org/10.1016/s0960-9822(99)80458-8
41 https://doi.org/10.1016/s1476-5586(04)80047-2
42 https://doi.org/10.1073/pnas.0504126102
43 https://doi.org/10.1074/jbc.273.9.4827
44 https://doi.org/10.1074/jbc.m403726200
45 https://doi.org/10.1083/jcb.200102032
46 https://doi.org/10.1084/jem.194.3.275
47 https://doi.org/10.1084/jem.20041247
48 https://doi.org/10.1084/jem.20041306
49 https://doi.org/10.1084/jem.20041817
50 https://doi.org/10.1093/emboj/19.19.5114
51 https://doi.org/10.1093/intimm/dxm015
52 https://doi.org/10.1093/jb/mvm127
53 https://doi.org/10.1093/jnci/88.22.1676
54 https://doi.org/10.1097/00022744-200206000-00001
55 https://doi.org/10.1097/00129039-200206000-00001
56 https://doi.org/10.1101/gad.943001
57 https://doi.org/10.1126/science.1127142
58 https://doi.org/10.1128/mcb.19.12.8314
59 https://doi.org/10.1128/mcb.26.7.2479-2489.2006
60 https://doi.org/10.1158/0008-5472.can-06-4517
61 https://doi.org/10.1172/jci31854
62 https://doi.org/10.1182/blood-2006-10-055194
63 https://doi.org/10.4049/jimmunol.176.7.3958
64 schema:datePublished 2010-03
65 schema:datePublishedReg 2010-03-01
66 schema:description Genome-wide analyses of human lung adenocarcinoma have identified regions of consistent copy-number gain or loss, but in many cases the oncogenes and tumor suppressors presumed to reside in these loci remain to be determined. Here we identify the downstream of tyrosine kinase (Dok) family members Dok1, Dok2 and Dok3 as lung tumor suppressors. Single, double or triple compound loss of these genes in mice results in lung cancer, with penetrance and latency dependent on the number of lost Dok alleles. Cancer development is preceded by an aberrant expansion and signaling profile of alveolar type II cells and bronchioalveolar stem cells. In human lung adenocarcinoma, we identify DOK2 as a target of copy-number loss and mRNA downregulation and find that DOK2 suppresses lung cancer cell proliferation in vitro and in vivo. Given the genomic localization of DOK2, we propose it as an 8p21.3 haploinsufficient human lung tumor suppressor.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf N4399e776a18d449585342b275ac619ef
71 N896fd95a7d254f26b37ae42d072ad1d4
72 sg:journal.1103138
73 schema:name Identification of DOK genes as lung tumor suppressors
74 schema:pagination 216
75 schema:productId N0aaea291a11743038f6b7d53e1f3b031
76 N0d683b2b1d294115ae7c0cf0daddaed8
77 N1cfa733c16f748f3aae75548715b642d
78 N328d4ceebf33466da21f68bf4a843815
79 Nb847fba84a8d4eebac9f474bce0cd7b5
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009971742
81 https://doi.org/10.1038/ng.527
82 schema:sdDatePublished 2019-04-11T10:03
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N2a8b4a1c022b49d18b92d71047c875f9
85 schema:url https://www.nature.com/articles/ng.527
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N0aaea291a11743038f6b7d53e1f3b031 schema:name nlm_unique_id
90 schema:value 9216904
91 rdf:type schema:PropertyValue
92 N0d075d95921b49f39e52523ad6de4311 rdf:first sg:person.01062522214.37
93 rdf:rest N8b6932afbded40dd8c629ccb81d0e8fc
94 N0d683b2b1d294115ae7c0cf0daddaed8 schema:name readcube_id
95 schema:value 2f8163bd8b90426807e01b90a8a40621671be8915de1bdf55369f03b42fe6db6
96 rdf:type schema:PropertyValue
97 N1896f456948a40deb9cb6952d1b34b24 rdf:first sg:person.01162424060.20
98 rdf:rest Nba0f820256d44488add166269d8ff988
99 N1b44edd954a140bfb0104ac304605787 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Phosphoproteins
101 rdf:type schema:DefinedTerm
102 N1b675b21dcc24080b9381bdb53306f8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Lung Neoplasms
104 rdf:type schema:DefinedTerm
105 N1cfa733c16f748f3aae75548715b642d schema:name dimensions_id
106 schema:value pub.1009971742
107 rdf:type schema:PropertyValue
108 N23044c522cf94f2e98756f8f1e6e6829 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name DNA-Binding Proteins
110 rdf:type schema:DefinedTerm
111 N2a8b4a1c022b49d18b92d71047c875f9 schema:name Springer Nature - SN SciGraph project
112 rdf:type schema:Organization
113 N2c39991a86f44bb0840c5ca55e31eabb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Tumor Cells, Cultured
115 rdf:type schema:DefinedTerm
116 N326d8fdee5d4470d92f08ed94402893f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Animals
118 rdf:type schema:DefinedTerm
119 N328d4ceebf33466da21f68bf4a843815 schema:name pubmed_id
120 schema:value 20139980
121 rdf:type schema:PropertyValue
122 N3359f4db876b437093f7709bccbb5f81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Mice, Nude
124 rdf:type schema:DefinedTerm
125 N3a11dde89c134ad89d19353c5533c40f rdf:first sg:person.01006355642.64
126 rdf:rest Nb25efab89ba44565bf57f13603f6dc29
127 N3fa6c3985a6c42be851f9f6961762bca rdf:first sg:person.010357032237.05
128 rdf:rest N8c083ca1c13b44389fa06e7165879a91
129 N4399e776a18d449585342b275ac619ef schema:volumeNumber 42
130 rdf:type schema:PublicationVolume
131 N45a6e3ece18249f99ddf5ccb9c5e2efc rdf:first sg:person.0765424143.23
132 rdf:rest Nb51e85be459f404597028484273694f9
133 N466347b5cc5647468b5a72af41887537 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Humans
135 rdf:type schema:DefinedTerm
136 N4b09066476c04e1ea369726d890b8b10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Gene Expression Regulation, Neoplastic
138 rdf:type schema:DefinedTerm
139 N631469a0e12841189daed6511ff59253 rdf:first sg:person.01333376013.47
140 rdf:rest N3fa6c3985a6c42be851f9f6961762bca
141 N6c27afd9cdbf43ceaf7b3ce8c3da516e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cell Proliferation
143 rdf:type schema:DefinedTerm
144 N781ed25d36314810b1120e3d9fc78cc7 rdf:first sg:person.01004527100.54
145 rdf:rest N3a11dde89c134ad89d19353c5533c40f
146 N78af7a1870b348fa84560ba5027aca64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Mice, Knockout
148 rdf:type schema:DefinedTerm
149 N7e679c26e0e84d0d933734dd2e666a39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Tumor Burden
151 rdf:type schema:DefinedTerm
152 N859dea89c9d2452994dc4eff80685cc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name RNA-Binding Proteins
154 rdf:type schema:DefinedTerm
155 N896fd95a7d254f26b37ae42d072ad1d4 schema:issueNumber 3
156 rdf:type schema:PublicationIssue
157 N89a557f279964c4c80c34f78d29638a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Adenocarcinoma
159 rdf:type schema:DefinedTerm
160 N8b6932afbded40dd8c629ccb81d0e8fc rdf:first sg:person.01155670023.16
161 rdf:rest N781ed25d36314810b1120e3d9fc78cc7
162 N8c083ca1c13b44389fa06e7165879a91 rdf:first sg:person.0712021032.88
163 rdf:rest N0d075d95921b49f39e52523ad6de4311
164 N9a55ede9f8a14568b92e4fffb92bda54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Genetic Predisposition to Disease
166 rdf:type schema:DefinedTerm
167 Nae0cb84db98e401a9b99a850277b24ef rdf:first sg:person.0602422363.19
168 rdf:rest N45a6e3ece18249f99ddf5ccb9c5e2efc
169 Nb186033e71974d4d93a4257782ff10d1 rdf:first sg:person.01355745464.73
170 rdf:rest rdf:nil
171 Nb25efab89ba44565bf57f13603f6dc29 rdf:first sg:person.0744143643.34
172 rdf:rest N1896f456948a40deb9cb6952d1b34b24
173 Nb51e85be459f404597028484273694f9 rdf:first sg:person.01313536640.26
174 rdf:rest N631469a0e12841189daed6511ff59253
175 Nb847fba84a8d4eebac9f474bce0cd7b5 schema:name doi
176 schema:value 10.1038/ng.527
177 rdf:type schema:PropertyValue
178 Nba0f820256d44488add166269d8ff988 rdf:first sg:person.01146507367.50
179 rdf:rest Nb186033e71974d4d93a4257782ff10d1
180 Ne537c560139b454e8fc7c73d0ef5938a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Adaptor Proteins, Signal Transducing
182 rdf:type schema:DefinedTerm
183 Neb004d93eb994ce686aeec1ab71b8c8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Genes, Tumor Suppressor
185 rdf:type schema:DefinedTerm
186 Nee17817d86c9448d8aa88a2abc59aa95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Transplantation, Heterologous
188 rdf:type schema:DefinedTerm
189 Needf834c17b14d879da5e1b23b69a607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Mice
191 rdf:type schema:DefinedTerm
192 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
193 schema:name Medical and Health Sciences
194 rdf:type schema:DefinedTerm
195 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
196 schema:name Oncology and Carcinogenesis
197 rdf:type schema:DefinedTerm
198 sg:grant.2435641 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.527
199 rdf:type schema:MonetaryGrant
200 sg:grant.2435846 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.527
201 rdf:type schema:MonetaryGrant
202 sg:grant.2479742 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.527
203 rdf:type schema:MonetaryGrant
204 sg:grant.2480693 http://pending.schema.org/fundedItem sg:pub.10.1038/ng.527
205 rdf:type schema:MonetaryGrant
206 sg:journal.1103138 schema:issn 1061-4036
207 1546-1718
208 schema:name Nature Genetics
209 rdf:type schema:Periodical
210 sg:person.01004527100.54 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
211 schema:familyName Motoi
212 schema:givenName Noriko
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004527100.54
214 rdf:type schema:Person
215 sg:person.01006355642.64 schema:affiliation https://www.grid.ac/institutes/grid.214572.7
216 schema:familyName Rothman
217 schema:givenName Paul B
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006355642.64
219 rdf:type schema:Person
220 sg:person.010357032237.05 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
221 schema:familyName Socci
222 schema:givenName Nicholas D
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010357032237.05
224 rdf:type schema:Person
225 sg:person.01062522214.37 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
226 schema:familyName Brennan
227 schema:givenName Cameron
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062522214.37
229 rdf:type schema:Person
230 sg:person.01146507367.50 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
231 schema:familyName Ladanyi
232 schema:givenName Marc
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146507367.50
234 rdf:type schema:Person
235 sg:person.01155670023.16 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
236 schema:familyName Szoke
237 schema:givenName Janos
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155670023.16
239 rdf:type schema:Person
240 sg:person.01162424060.20 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
241 schema:familyName Gerald
242 schema:givenName William L
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162424060.20
244 rdf:type schema:Person
245 sg:person.01313536640.26 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
246 schema:familyName Morotti
247 schema:givenName Alessandro
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313536640.26
249 rdf:type schema:Person
250 sg:person.01333376013.47 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
251 schema:familyName Taylor
252 schema:givenName Barry S
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333376013.47
254 rdf:type schema:Person
255 sg:person.01355745464.73 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
256 schema:familyName Pandolfi
257 schema:givenName Pier Paolo
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355745464.73
259 rdf:type schema:Person
260 sg:person.0602422363.19 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
261 schema:familyName Berger
262 schema:givenName Alice H
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602422363.19
264 rdf:type schema:Person
265 sg:person.0712021032.88 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
266 schema:familyName Viale
267 schema:givenName Agnes
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712021032.88
269 rdf:type schema:Person
270 sg:person.0744143643.34 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
271 schema:familyName Teruya-Feldstein
272 schema:givenName Julie
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744143643.34
274 rdf:type schema:Person
275 sg:person.0765424143.23 schema:affiliation https://www.grid.ac/institutes/grid.214572.7
276 schema:familyName Niki
277 schema:givenName Masaru
278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765424143.23
279 rdf:type schema:Person
280 sg:pub.10.1038/nature06358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019681472
281 https://doi.org/10.1038/nature06358
282 rdf:type schema:CreativeWork
283 sg:pub.10.1038/ng2037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050222108
284 https://doi.org/10.1038/ng2037
285 rdf:type schema:CreativeWork
286 sg:pub.10.1038/onc.2009.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049951245
287 https://doi.org/10.1038/onc.2009.135
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/sj.onc.1207947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010933002
290 https://doi.org/10.1038/sj.onc.1207947
291 rdf:type schema:CreativeWork
292 sg:pub.10.1186/1471-2164-8-140 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033033278
293 https://doi.org/10.1186/1471-2164-8-140
294 rdf:type schema:CreativeWork
295 sg:pub.10.1532/ijh97.05144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026541312
296 https://doi.org/10.1532/ijh97.05144
297 rdf:type schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1074361777 schema:CreativeWork
299 https://app.dimensions.ai/details/publication/pub.1074578264 schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1075839608 schema:CreativeWork
301 https://app.dimensions.ai/details/publication/pub.1077005561 schema:CreativeWork
302 https://app.dimensions.ai/details/publication/pub.1082424623 schema:CreativeWork
303 https://app.dimensions.ai/details/publication/pub.1082807381 schema:CreativeWork
304 https://doi.org/10.1002/gcc.2870070204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051575092
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.cell.2005.02.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047408290
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.cell.2005.03.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006708194
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s0002-9440(10)61257-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009312131
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s0092-8674(00)81840-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021110000
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s0092-8674(00)81841-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029007273
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s0960-9822(99)80458-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000695296
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s1476-5586(04)80047-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019351767
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1073/pnas.0504126102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006175044
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1074/jbc.273.9.4827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050439208
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1074/jbc.m403726200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015008529
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1083/jcb.200102032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003613500
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1084/jem.194.3.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026006079
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1084/jem.20041247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002754114
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1084/jem.20041306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052469899
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1084/jem.20041817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045393486
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/emboj/19.19.5114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033404333
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/intimm/dxm015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039080457
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/jb/mvm127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059745762
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/jnci/88.22.1676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038758389
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1097/00022744-200206000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038850955
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1097/00129039-200206000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047460585
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1101/gad.943001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007211161
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1126/science.1127142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062453749
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1128/mcb.19.12.8314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007276801
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1128/mcb.26.7.2479-2489.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051058539
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1158/0008-5472.can-06-4517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041137532
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1172/jci31854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024226963
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1182/blood-2006-10-055194 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051049280
361 rdf:type schema:CreativeWork
362 https://doi.org/10.4049/jimmunol.176.7.3958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051715080
363 rdf:type schema:CreativeWork
364 https://www.grid.ac/institutes/grid.214572.7 schema:alternateName University of Iowa
365 schema:name Cancer Biology and Genetics Program, Sloan-Kettering Institute, New York, New York, USA.
366 Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
367 Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
368 rdf:type schema:Organization
369 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
370 schema:name Bioinformatics Core, Sloan-Kettering Institute, New York, New York, USA.
371 Cancer Biology and Genetics Program, Sloan-Kettering Institute, New York, New York, USA.
372 Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
373 Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
374 Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
375 Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
376 Genomics Core Laboratory, Sloan-Kettering Institute, New York, New York, USA.
377 Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
380 schema:name Cancer Biology and Genetics Program, Sloan-Kettering Institute, New York, New York, USA.
381 Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Departments of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
382 Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
383 Weill Graduate School of Medical Sciences, Cornell University, New York, New York, USA.
384 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...