Genome-wide association study of PR interval View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01-10

AUTHORS

Arne Pfeufer, Charlotte van Noord, Kristin D Marciante, Dan E Arking, Martin G Larson, Albert Vernon Smith, Kirill V Tarasov, Martina Müller, Nona Sotoodehnia, Moritz F Sinner, Germaine C Verwoert, Man Li, W H Linda Kao, Anna Köttgen, Josef Coresh, Joshua C Bis, Bruce M Psaty, Kenneth Rice, Jerome I Rotter, Fernando Rivadeneira, Albert Hofman, Jan A Kors, Bruno H C Stricker, André G Uitterlinden, Cornelia M van Duijn, Britt M Beckmann, Wiebke Sauter, Christian Gieger, Steven A Lubitz, Christopher Newton-Cheh, Thomas J Wang, Jared W Magnani, Renate B Schnabel, Mina K Chung, John Barnard, Jonathan D Smith, David R Van Wagoner, Ramachandran S Vasan, Thor Aspelund, Gudny Eiriksdottir, Tamara B Harris, Lenore J Launer, Samer S Najjar, Edward Lakatta, David Schlessinger, Manuela Uda, Gonçalo R Abecasis, Bertram Müller-Myhsok, Georg B Ehret, Eric Boerwinkle, Aravinda Chakravarti, Elsayed Z Soliman, Kathryn L Lunetta, Siegfried Perz, H-Erich Wichmann, Thomas Meitinger, Daniel Levy, Vilmundur Gudnason, Patrick T Ellinor, Serena Sanna, Stefan Kääb, Jacqueline C M Witteman, Alvaro Alonso, Emelia J Benjamin, Susan R Heckbert

ABSTRACT

Arne Pfeufer and colleagues report a genome-wide association study of the electrocardiographic measurement of PR interval in seven population-based cohorts in the CHARGE consortium. They identify nine loci associated with PR interval and highlight candidate genes with a role in ion channels and cardiac development.

PAGES

153-159

Journal

TITLE

Nature Genetics

ISSUE

2

VOLUME

42

Author Affiliations

  • Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
  • Netherlands Consortium on Healthy Aging (NCHA) Leiden, The Netherlands
  • Department of Medicine, University of Washington, Seattle, Washington, USA
  • McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA
  • National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA
  • Icelandic Heart Association, Heart Preventive Clinic and Research Institute, Kopavogur, Iceland
  • Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA
  • Department of Medicine I, Klinikum Grosshadern, Munich, Germany
  • Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
  • Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
  • Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
  • Group Health Research Institute, Seattle, Washington, USA
  • Department of Biostatistics, University of Washington, Seattle, Washington, USA
  • Department of Common Diseases Genetics Program, Medical Genetics Institute, Cedars-Sinai Medical Center, West Hollywood, California, USA
  • Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
  • Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands
  • Inspectorate for Health Care, The Hague, The Netherlands
  • Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
  • Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
  • Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
  • Boston University School of Medicine, Boston, Massachusetts, USA
  • Gutenberg Heart Study, Medical Clinic II (Cardiology), Johannes Gutenberg-University, Mainz, Germany
  • Heart & Vascular and Lerner Research Institutes, Cleveland Clinic, Cleveland, Ohio, USA
  • Heart Preventive Clinical and Research Institute, University of Iceland, Reykjavik, Iceland
  • Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Baltimore, Maryland, USA
  • Laboratory of Cardiovascular Science, National Institute on Aging, Baltimore, Maryland, USA
  • Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy.
  • Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
  • Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany
  • Human Genetics Center and Institute for Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA
  • Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
  • Department of Epidemiology and Prevention, Division of Public Health Sciences, Epidemiological Cardiology Research Center (EPICARE), Wake Forest University Medical Center, Winston-Salem, North Carolina, USA
  • Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
  • Institute of Biological and Medical Imaging, Helmholtz Center, Munich, Germany
  • Klinikum Grosshadern, Munich, Germany
  • Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
  • Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
  • Cardiology and Preventive Medicine Division, Evans Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.517

    DOI

    http://dx.doi.org/10.1038/ng.517

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003591401

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20062060


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