Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-11-08

AUTHORS

Soumya Raychaudhuri, Brian P Thomson, Elaine F Remmers, Stephen Eyre, Anne Hinks, Candace Guiducci, Joseph J Catanese, Gang Xie, Eli A Stahl, Robert Chen, Lars Alfredsson, Christopher I Amos, Kristin G Ardlie, Anne Barton, John Bowes, Noel P Burtt, Monica Chang, Jonathan Coblyn, Karen H Costenbader, Lindsey A Criswell, J Bart A Crusius, Jing Cui, Phillip L De Jager, Bo Ding, Paul Emery, Edward Flynn, Pille Harrison, Lynne J Hocking, Tom W J Huizinga, Daniel L Kastner, Xiayi Ke, Fina A S Kurreeman, Annette T Lee, Xiangdong Liu, Yonghong Li, Paul Martin, Ann W Morgan, Leonid Padyukov, David M Reid, Mark Seielstad, Michael F Seldin, Nancy A Shadick, Sophia Steer, Paul P Tak, Wendy Thomson, Annette H M van der Helm-van Mil, Irene E van der Horst-Bruinsma, Michael E Weinblatt, Anthony G Wilson, Gert Jan Wolbink, Paul Wordsworth, David Altshuler, Elizabeth W Karlson, Rene E M Toes, Niek de Vries, Ann B Begovich, Katherine A Siminovitch, Jane Worthington, Lars Klareskog, Peter K Gregersen, Mark J Daly, Robert M Plenge

ABSTRACT

Soumya Raychaudhuri and colleagues demonstrate the utility of GRAIL, a software program used to prioritize results from genome-wide association studies for further replication, applied here to rheumatoid arthritis. The authors seek replication of their predictions in additional independent cohorts and report three new genetic loci associated with RA susceptibility.

PAGES

1313-1318

References to SciGraph publications

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  • Journal

    TITLE

    Nature Genetics

    ISSUE

    12

    VOLUME

    41

    Author Affiliations

  • Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
  • Broad Institute, Cambridge, Massachusetts, USA
  • Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, US National Institutes of Health, Bethesda, Maryland, USA
  • Arthritis Research Campaign (arc)–Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
  • Celera, Alameda, California, USA
  • Department of Medicine, University of Toronto, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada
  • Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA
  • Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
  • University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
  • Department of Medicine, Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, California, USA
  • Department of Pathology, Laboratory of Immunogenetics, VU University Medical Center, Amsterdam, The Netherlands
  • Department of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA
  • National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, United Kingdom
  • University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, United Kingdom
  • Division of Applied Medicine, Musculoskeletal and Genetics Section, University of Aberdeen, United Kingdom
  • Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
  • The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, USA
  • Department of Medicine, Rheumatology Unit, Karolinska Institutet at Karolinska University Hospital Solna, Stockholm, Sweden
  • Genome Institute of Singapore, Singapore
  • Rowe Program in Genetics, University of California at Davis, Davis, California, USA
  • Clinical and Academic Rheumatology, Kings College Hospital National Health Service Foundation Trust, Denmark Hill, London, United Kingdom
  • Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  • Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
  • School of Medicine and Biomedical Sciences, Sheffield University, Sheffield, United Kingdom
  • Sanquin Research Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  • Roche Diagnostics, Pleasanton, California, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.479

    DOI

    http://dx.doi.org/10.1038/ng.479

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036867278

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19898481


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