Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-07-13

AUTHORS

Emelia J Benjamin, Kenneth M Rice, Dan E Arking, Arne Pfeufer, Charlotte van Noord, Albert V Smith, Renate B Schnabel, Joshua C Bis, Eric Boerwinkle, Moritz F Sinner, Abbas Dehghan, Steven A Lubitz, Ralph B D'Agostino Sr, Thomas Lumley, Georg B Ehret, Jan Heeringa, Thor Aspelund, Christopher Newton-Cheh, Martin G Larson, Kristin D Marciante, Elsayed Z Soliman, Fernando Rivadeneira, Thomas J Wang, Gudny Eiríksdottir, Daniel Levy, Bruce M Psaty, Man Li, Alanna M Chamberlain, Albert Hofman, Ramachandran S Vasan, Tamara B Harris, Jerome I Rotter, W H Linda Kao, Sunil K Agarwal, Bruno H Ch Stricker, Ke Wang, Lenore J Launer, Nicholas L Smith, Aravinda Chakravarti, André G Uitterlinden, Philip A Wolf, Nona Sotoodehnia, Anna Köttgen, Cornelia M van Duijn, Thomas Meitinger, Martina Mueller, Siegfried Perz, Gerhard Steinbeck, H-Erich Wichmann, Kathryn L Lunetta, Susan R Heckbert, Vilmundur Gudnason, Alvaro Alonso, Stefan Kääb, Patrick T Ellinor, Jacqueline C M Witteman

ABSTRACT

Emelia Benjamin and colleagues report a meta-analysis of genome-wide association study data for atrial fibrillation, a condition associated with stroke and heart failure, in five European community-based cohorts of the CHARGE consortium. They report an association in ZFHX3 to atrial fibrillation, with replication in an independent cohort from the German AF Network. More... »

PAGES

879-881

Journal

TITLE

Nature Genetics

ISSUE

8

VOLUME

41

Author Affiliations

  • Epidemiology Department, Boston University School of Public Health, Boston, Massachusetts, USA
  • Department of Biostatistics, University of Washington, Seattle, Washington, USA
  • McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
  • Department of Human Genetics, Helmholtz Center Munich, German National Research Center for Environmental Health, Munich, Germany
  • Netherlands Consortium on Healthy Aging, Leiden, The Netherlands
  • Icelandic Heart Association, Kópavogur, Iceland
  • Gutenberg Heart Study, Medical Clinic II (Cardiology), Johannes Gutenberg-University, Mainz, Germany
  • Department of Medicine, University of Washington, Seattle, Washington, USA
  • Human Genetics Center and Division of Epidemiology, University of Texas Health Science Center at Houston, Houston, Texas, USA
  • Department of Medicine I, Ludwig Maximilians University Munich, Klinikum Grosshadern, Munich, Germany
  • Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
  • Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
  • Department of Mathematics & Statistics, Boston University, Boston, Massachusetts, USA
  • University of Iceland, Reykjavik, Iceland
  • Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
  • Department of General Internal Medicine, University of Washington, Seattle, Washington, USA
  • Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center (EPICARE), Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
  • Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
  • Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Center for Population Studies, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
  • Center for Health Studies, Group Health, Seattle, Washington, USA
  • Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
  • Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
  • Department of Medicine, Cardiology and Preventive Medicine Sections, Boston University School of Medicine, Boston, Massachusetts, USA
  • Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA
  • Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
  • Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
  • Inspectorate for Health Care, The Hague, The Netherlands
  • Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
  • Seattle Epidemiologic Research and Information Center of the Department of Veterans Affairs Office of Research and Development, Seattle, Washington, USA
  • Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands
  • Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
  • Division of Cardiology, University of Washington, Seattle, Washington, USA
  • Department of Human Genetics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany
  • Institut für Epidemiologie, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Munich, Germany
  • Institute of Medical Informatics, Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany
  • Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University, Munich, Germany
  • Cardiac Arrhythmia Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.416

    DOI

    http://dx.doi.org/10.1038/ng.416

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004086691

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19597492


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