SMARCB1 is required for widespread BAF complex–mediated activation of enhancers and bivalent promoters View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-09-25

AUTHORS

Robert T Nakayama, John L Pulice, Alfredo M Valencia, Matthew J McBride, Zachary M McKenzie, Mark A Gillespie, Wai Lim Ku, Mingxiang Teng, Kairong Cui, Robert T Williams, Seth H Cassel, He Qing, Christian J Widmer, George D Demetri, Rafael A Irizarry, Keji Zhao, Jeffrey A Ranish, Cigall Kadoch

ABSTRACT

Loss of BAF47 destabilizes the BAF complex on chromatin, and reintroduction of BAF47 leads to enhancer activation and Polycomb opposition at bivalent promoters. BAF47 loss affects BAF and PBAF complexes, which have distinct functions in regulation of enhancers and promoters.

PAGES

1613-1623

References to SciGraph publications

  • 2015-12-23. Insulator dysfunction and oncogene activation in IDH mutant gliomas in NATURE
  • 2004-03-01. Loss of the INI1 tumor suppressor does not impair the expression of multiple BRG1-dependent genes or the assembly of SWI/SNF enzymes in ONCOGENE
  • 2011-07-24. esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function in NATURE CELL BIOLOGY
  • 2008-09-17. Model-based Analysis of ChIP-Seq (MACS) in GENOME BIOLOGY
  • 2016-12-12. SMARCB1-mediated SWI/SNF complex function is essential for enhancer regulation in NATURE GENETICS
  • 2008-11-30. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification in NATURE BIOTECHNOLOGY
  • 1998-07. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer in NATURE
  • 2017-02-08. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer in NATURE
  • 1994-08. Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex in NATURE
  • 2014-12-05. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 in GENOME BIOLOGY
  • 2016-01-27. Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells in NATURE
  • 2013-05-05. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy in NATURE GENETICS
  • 2013-12-08. Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2012-01-24. Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization in CELL RESEARCH
  • 2014-01. Identification of alternative topological domains in chromatin in ALGORITHMS FOR MOLECULAR BIOLOGY
  • 2013-06-16. Mutational heterogeneity in cancer and the search for new cancer-associated genes in NATURE
  • 2007-07-01. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells in NATURE
  • 2010-01-27. Chromatin remodelling during development in NATURE
  • 2012-03-18. Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome in NATURE GENETICS
  • 2016-12-12. Dynamics of BAF–Polycomb complex opposition on heterochromatin in normal and oncogenic states in NATURE GENETICS
  • 2012-03-04. Fast gapped-read alignment with Bowtie 2 in NATURE METHODS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3958

    DOI

    http://dx.doi.org/10.1038/ng.3958

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1091914196

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28945250


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