Identification of sequence variants influencing immunoglobulin levels View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08

AUTHORS

Stefan Jonsson, Gardar Sveinbjornsson, Aitzkoa Lopez de Lapuente Portilla, Bhairavi Swaminathan, Rosina Plomp, Gillian Dekkers, Ram Ajore, Mina Ali, Arthur E H Bentlage, Evelina Elmér, Gudmundur I Eyjolfsson, Sigurjon A Gudjonsson, Urban Gullberg, Arnaldur Gylfason, Bjarni V Halldorsson, Markus Hansson, Hilma Holm, Åsa Johansson, Ellinor Johnsson, Aslaug Jonasdottir, Bjorn R Ludviksson, Asmundur Oddsson, Isleifur Olafsson, Sigurgeir Olafsson, Olof Sigurdardottir, Asgeir Sigurdsson, Lilja Stefansdottir, Gisli Masson, Patrick Sulem, Manfred Wuhrer, Anna-Karin Wihlborg, Gudmar Thorleifsson, Daniel F Gudbjartsson, Unnur Thorsteinsdottir, Gestur Vidarsson, Ingileif Jonsdottir, Björn Nilsson, Kari Stefansson

ABSTRACT

Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a genome-wide association study of 19,219 individuals, we found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci. Variants at these loci also affect the risk of autoimmune diseases and blood malignancies and influence blood cell development. Notable associations include a rare variant at RUNX3 decreasing IgA levels by shifting isoform proportions (rs188468174[C>T]: P = 8.3 × 10-55, β = -0.90 s.d.), a rare in-frame deletion in FCGR2B abolishing IgG binding to the encoded receptor (p.Asn106del: P = 4.2 × 10-8, β = 1.03 s.d.), four IGH locus variants influencing class switching, and ten new associations with the HLA region. Our results provide new insight into the regulation of humoral immunity. More... »

PAGES

1182-1191

References to SciGraph publications

  • 2012-10. Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers in IMMUNOGENETICS
  • 1973-03. Human Lymphocyte Antigen Association in Ankylosing Spondylitis in NATURE
  • 2016-10. Functional Genomics and Its Bench-to-Bedside Translation Pertaining to the Identified Susceptibility Alleles and Loci in Ankylosing Spondylitis in CURRENT RHEUMATOLOGY REPORTS
  • 2015-03. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies in NATURE GENETICS
  • 2015-12. Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma in NATURE COMMUNICATIONS
  • 2013-09. Transcriptome and genome sequencing uncovers functional variation in humans in NATURE
  • 2016-02. Genetics of ankylosing spondylitis—insights into pathogenesis in NATURE REVIEWS RHEUMATOLOGY
  • 2016-10. Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution in NATURE GENETICS
  • 2012-04. Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond in NATURE REVIEWS DRUG DISCOVERY
  • 2014-06. The BAFF/APRIL system in SLE pathogenesis in NATURE REVIEWS RHEUMATOLOGY
  • 2016-12. Global gene regulation during activation of immunoglobulin class switching in human B cells in SCIENTIFIC REPORTS
  • 2016-03. Weighting sequence variants based on their annotation increases power of whole-genome association studies in NATURE GENETICS
  • 2009-03. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction in NATURE GENETICS
  • 2015-10. A global reference for human genetic variation in NATURE
  • 2015-02. Integrative analysis of 111 reference human epigenomes in NATURE
  • 2016-03. HLA class II sequence variants influence tuberculosis risk in populations of European ancestry in NATURE GENETICS
  • 2015-05. Large-scale whole-genome sequencing of the Icelandic population in NATURE GENETICS
  • 2008-03. Genetics of gene expression and its effect on disease in NATURE
  • 2004-05. The Runx genes: lineage-specific oncogenes and tumor suppressors in ONCOGENE
  • 2011-08. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling in NATURE
  • 2013-10. Systematic identification of trans eQTLs as putative drivers of known disease associations in NATURE GENETICS
  • 2006-08. Principal components analysis corrects for stratification in genome-wide association studies in NATURE GENETICS
  • 2016-11. Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency in NATURE GENETICS
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2012-09. Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population in GENES & IMMUNITY
  • 2007-04. Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency in NATURE GENETICS
  • 2012-11. Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease in NATURE
  • 2013-05. Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits in NATURE
  • 2011-03. Initial genome sequencing and analysis of multiple myeloma in NATURE
  • 2015-04. The higher frequency of IgA deficiency among Swedish twins is not explained by HLA haplotypes in GENES & IMMUNITY
  • 2016-11-16. Epigenetic and genetic components of height regulation in NATURE COMMUNICATIONS
  • 2015. Eukaryotic Glycosylation: Online Methods for Site Prediction on Protein Sequences in GLYCOINFORMATICS
  • 2008-09. Detection of sharing by descent, long-range phasing and haplotype imputation in NATURE GENETICS
  • 2014-02. Genetics of rheumatoid arthritis contributes to biology and drug discovery in NATURE
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    http://scigraph.springernature.com/pub.10.1038/ng.3897

    DOI

    http://dx.doi.org/10.1038/ng.3897

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1086072585

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28628107


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    780 schema:name School of Science and Engineering, Reykjavik University, Reykjavik, Iceland.
    781 deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
    782 rdf:type schema:Organization
     




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