Genome-wide characterization of mammalian promoters with distal enhancer functions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06-05

AUTHORS

Lan T M Dao, Ariel O Galindo-Albarrán, Jaime A Castro-Mondragon, Charlotte Andrieu-Soler, Alejandra Medina-Rivera, Charbel Souaid, Guillaume Charbonnier, Aurélien Griffon, Laurent Vanhille, Tharshana Stephen, Jaafar Alomairi, David Martin, Magali Torres, Nicolas Fernandez, Eric Soler, Jacques van Helden, Denis Puthier, Salvatore Spicuglia

ABSTRACT

Salvatore Spicuglia and colleagues use a high-throughput reporter assay to identify a set of mammalian promoters, termed Epromoters, that display enhancer activity and have distinct genomic and epigenomic features. Through CRISPR–Cas9 gene editing experiments, they show that Epromoters are involved in long-range gene regulation in cis.

PAGES

1073-1081

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ng.3884

    DOI

    http://dx.doi.org/10.1038/ng.3884

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085862021

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28581502


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